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2-Bromo-4,6-dimethylpyridine

2-Bromo-4,6-dimethylpyridine structure

CAS No.: 4926-26-5

Chemical Name:: 2-Bromo-4,6-dimethylpyridine

Synonyms: 2-Bromo-4,6-lutidine;2-Brom-4,6-dimethylpyridin;6-BroMo-2,4-diMethylpyridine;2-Bromo-4,6-dimethylpyridine;2-Bromo-2,4-dimethyl-pyridine;Pyridine, 2-bromo-4,6-dimethyl-;2-bromo-4,6-dimethylpyridine(SALTDATA: FREE);2-BROMO-4,6-DIMETHYLPYRIDINE ISO 9001：2015 REACH;7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

CBNumber:: CB7361364

Molecular Formula:: C7H8BrN

Molecular Weight:: 186.05

MDL Number:: MFCD00082591

MOL File:: 4926-26-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:55

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2-Bromo-4,6-dimethylpyridine Properties

Boiling point	68°C/0.8mmHg(lit.)
Density	1.415±0.06 g/cm3(Predicted)
refractive index	1.5510 to 1.5550
storage temp.	Inert atmosphere,Room Temperature
form	clear liquid
pka	2.17±0.10(Predicted)
color	Colorless to Light yellow
λmax	268nm(EtOH)(lit.)
InChI	InChI=1S/C7H8BrN/c1-5-3-6(2)9-7(8)4-5/h3-4H,1-2H3
InChIKey	IRTOCXBLUOPRFT-UHFFFAOYSA-N
SMILES	C1(Br)=NC(C)=CC(C)=C1
CAS DataBase Reference	4926-26-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

HS Code

2933399990

NFPA 704

	2
2		0

2-Bromo-4,6-dimethylpyridine price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5254	2-Bromo-4,6-dimethylpyridine >98.0%(T)	4926-26-5	1g	$129	2026-04-30	Buy
TCI Chemical	B5254	2-Bromo-4,6-dimethylpyridine >98.0%(T)	4926-26-5	5g	$387	2026-04-30	Buy
Usbiological	415967	2-Bromo-4,6-dimethylpyridine	4926-26-5	250mg	$312	2026-06-03	Buy
Usbiological	415967	2-Bromo-4,6-dimethylpyridine	4926-26-5	1g	$432	2026-06-03	Buy
Usbiological	261752	2-Bromo-4,6-dimethylpyridine Asreported	4926-26-5	250mg	$319	2026-06-03	Buy

Product number	Packaging	Price	Buy
B5254	1g	$129	Buy
B5254	5g	$387	Buy
415967	250mg	$312	Buy
415967	1g	$432	Buy
261752	250mg	$319	Buy

2-Bromo-4,6-dimethylpyridine Chemical Properties, Uses, Production

Chemical Properties

Light yellow Cryst

Uses

2-Bromo-4,6-dimethylpyridine is a reactant in regioselective and diastereoselective syntheses of the natural product CCR5 antagonist anibamine and its three olefin isomers.

Synthesis

5407-87-4

4926-26-5

General procedure for the synthesis of 2-bromo-4,6-dimethylpyridine from 2-amino-4,6-dimethylpyridine: A 48% aqueous hydrobromic acid solution (Aldrich, 65 mL, 1.2 mol, 10 eq.) was cooled to -5 °C and 4,6-dimethylpyridin-2-amine (Aldrich, 15.0 g, 0.12 mol, 1.0 eq.) was added. Bromine (Aldrich, 19.7 mL, 0.38 mol, 3.1 eq.) was added slowly and dropwise with mechanical stirring to the thick white salt mixture formed. The resulting red mixture was treated with aqueous sodium nitrite (32 mL water, Aldrich, 22.1 g, 0.32 mol, 2.6 eq.) for 1 hr below 5 °C. The temperature was maintained below 5°C during the nitrite addition process, followed by a gradual warming to 20°C over 2 hr. The reaction mixture was adjusted to pH 14 with aqueous sodium hydroxide and extracted with methyl tert-butyl ether (MTBE). The organic phase was washed sequentially with water and brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude product (29 g of red oily material) was purified by fast chromatography (silica gel, 350 g) using 2-7% ethyl acetate-cyclohexane as eluent to give an orange oily product (11.0 g, 48% yield). The product was purified by 1H NMR (DMSO-d6, 300 MHz) δ 7.30 (1H, s), 7.13 (1H, s), 2.39 (3H, s), 2.26 (3H, s); 13C NMR (DMSO-d6, 75 MHz) δ 159.4, 151.3, 140.9, 125.7, 123.4, 23.7, 20.3 ; ESI-MS m/z 186/188 ([M+H]+).

References

[1] Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 7945 - 7952
[2] Helvetica Chimica Acta, 1992, vol. 75, # 5, p. 1578 - 1592
[3] Patent: WO2004/56806, 2004, A1. Location in patent: Page 50
[4] Journal of Medicinal Chemistry, 2014, vol. 57, # 16, p. 7126 - 7135
[5] Patent: EP3124482, 2017, A1. Location in patent: Paragraph 0512; 0513

2-Bromo-4,6-dimethylpyridine synthesis

Synthesis of 2-Bromo-4,6-dimethylpyridine from 2-Amino-4,6-dimethylpyridine

2-Bromo-4,6-dimethylpyridine Preparation Products And Raw materials

Raw materials

2-Amino-4,6-dimethylpyridine Hydrogen bromide Sodium nitrite

Preparation Products

2-Bromo-4,6-dimethylpyridine Suppliers

Global Suppliers ( 136)

Supplier	Tel	Email	Country	ProdList	Advantage
Jiaxing Yat Tai Biotechnology Co. , Ltd.	15824386662	416719813@qq.com	China	111	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Nan Jing Dirise Chemcial Co.,LTD	025-52161033 15312098939	2432674894@qq.com	China	584	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9510	58

Supplier	Advantage
Jiaxing Yat Tai Biotechnology Co. , Ltd.	58
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
Pure Chemistry Scientific Inc.	62
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Nan Jing Dirise Chemcial Co.,LTD	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Shanghai Topbiochem Technology Co., Ltd	58

View Latest Price from 2-Bromo-4,6-dimethylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-BROMO-4,6-DIMETHYLPYRIDINE 4926-26-5	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2026-08-13	2-BROMO-4,6-DIMETHYLPYRIDINE 4926-26-5		1G	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2019-07-06	2-BROMO-4,6-DIMETHYLPYRIDINE 4926-26-5	$1.00	1KG	99%		Career Henan Chemical Co

2-BROMO-4,6-DIMETHYLPYRIDINE
4926-26-5
$1.10
99.00%
Dideu Industries Group Limited

2-BROMO-4,6-DIMETHYLPYRIDINE
4926-26-5
$0.00
98%
Shenzhen Nexcon Pharmatechs Ltd.

2-BROMO-4,6-DIMETHYLPYRIDINE
4926-26-5
$1.00
99%
Career Henan Chemical Co

2-Bromo-4,6-dimethylpyridine Spectrum

2-BROMO-4,6-DIMETHYLPYRIDINE(4926-26-5)¹HNMR

4926-26-5 (2-Bromo-4,6-dimethylpyridine) Related Search:

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2-Bromo-2,4-dimethyl-pyridine 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 6-BroMo-2,4-diMethylpyridine 2-bromo-4,6-dimethylpyridine(SALTDATA: FREE) Pyridine, 2-bromo-4,6-dimethyl- 2-Bromo-4,6-lutidine 2-BROMO-4,6-DIMETHYLPYRIDINE ISO 9001：2015 REACH 2-Brom-4,6-dimethylpyridin 2-Bromo-4,6-dimethylpyridine 4926-26-5 Heterocyclic Compounds Pyridines Boronic Acid Heterocycle-Pyridine series Pyridine Pyridine Series