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1-(2-Pyridyl)piperazine

1-(2-Pyridyl)piperazine structure

CAS No.: 34803-66-2

Chemical Name:: 1-(2-Pyridyl)piperazine

Synonyms: NSC13778;NSC 26624;NSC 137781;AKOS BBS-00003613;BUTTPARK 82\08-03;RARECHEM AH CK 0193;TIMTEC-BB SBB006445;2-pyridyl piperazine;2-piperazinopyridine;LABOTEST-BB LTBB000605

CBNumber:: CB7363328

Molecular Formula:: C9H13N3

Molecular Weight:: 163.22

MDL Number:: MFCD00006216

MOL File:: 34803-66-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:39:49

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1-(2-Pyridyl)piperazine Properties

Melting point	92-94
Boiling point	120-122 °C/2 mmHg (lit.)
Density	1.072 g/mL at 25 °C (lit.)
refractive index	n20/D 1.595(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in Chloroform, Methanol.
form	Liquid
pka	8.63±0.10(Predicted)
color	Clear colorless to yellow
Water Solubility	>500 g/L (20 ºC)
Sensitive	Air Sensitive
BRN	140423
InChI	1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChIKey	GZRKXKUVVPSREJ-UHFFFAOYSA-N
SMILES	C1CN(CCN1)c2ccccn2
CAS DataBase Reference	34803-66-2(CAS DataBase Reference)
FDA UNII	5IO1HZP7ZN
NIST Chemistry Reference	1-(2-Pyridyl)piperazine(34803-66-2)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

2735

WGK Germany

10-34

Hazard Note

Irritant

HazardClass

PackingGroup

HS Code

29339900

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

1-(2-Pyridyl)piperazine price More Price(88)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	151270	1-(2-Pyridyl)piperazine 98%	34803-66-2	5g	$70.9	2026-04-30	Buy
Sigma-Aldrich	151270	1-(2-Pyridyl)piperazine 98%	34803-66-2	25g	$137	2026-04-30	Buy
TCI Chemical	P1033	1-(2-Pyridyl)piperazine >98.0%(GC)(T)	34803-66-2	5g	$82	2026-04-30	Buy
TCI Chemical	P1033	1-(2-Pyridyl)piperazine >98.0%(GC)(T)	34803-66-2	25g	$219	2026-04-30	Buy
TRC	TRC-P995725-500MG	1-(2-Pyridyl)piperazine	34803-66-2	500mg	$74	2026-06-03	Buy

Product number	Packaging	Price	Buy
151270	5g	$70.9	Buy
151270	25g	$137	Buy
P1033	5g	$82	Buy
P1033	25g	$219	Buy
TRC-P995725-500MG	500mg	$74	Buy

1-(2-Pyridyl)piperazine Chemical Properties,Uses,Production

Chemical Properties

clear colourless to yellow liquid

Uses

1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli te of Azaperone (A802200).

Uses

1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air.

General Description

1-(2-Pyridyl)piperazine is a piperazine derivative.

Synthesis

110-85-0

109-04-6

34803-66-2

Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield.

References

[1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50

1-(2-Pyridyl)piperazine Preparation Products And Raw materials

Raw materials

Piperazine 1-Boc-4-(2-pyridinyl)-piperazine 2-Chloropyridine 2-Bromopyridine

Preparation Products

(4-fluorophenyl)[4-(pyridin-2-yl)piperazin-1-yl]methanone 1-Piperazinepropanenitrile, β-oxo-4-(2-pyridinyl)- 1-cinnamoyl-4-(2-pyridinyl)piperazine

1-(2-Pyridyl)piperazine Suppliers

Global( 322)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Tangwu Technology Co., Ltd	15632360893	hebeitangwukeji@163.com	China	36	58
Yangzhou Princechem Co.,Ltd	18921928333	david@princechem.com	China	498	58
Creasyn Finechem(Tianjin) Co., Ltd.	022-83946278 13820372920	sales@creasyn.com	China	968	68
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Hebei Tangwu Technology Co., Ltd	58
Yangzhou Princechem Co.,Ltd	58
Creasyn Finechem(Tianjin) Co., Ltd.	68
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61

View Lastest Price from 1-(2-Pyridyl)piperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-11-23	1-(2-pyridyl) piperazine 34803-66-2	$25.00	100KG	99%	5ton/Month	Qiuxian Baitai New Material Co., LTD
2020-01-10	1-(2-Pyridinyl)piperazine 34803-66-2	$1.00	1g	95-99%	1ton	Career Henan Chemical Co
2020-01-08	1-(2-Pyridyl)piperazine 34803-66-2		1KG	98%;99%	1kg； 5kg；10kg；25kg	Career Henan Chemical Co

1-(2-pyridyl) piperazine
34803-66-2
$25.00
99%
Qiuxian Baitai New Material Co., LTD

1-(2-Pyridinyl)piperazine
34803-66-2
$1.00
95-99%
Career Henan Chemical Co

1-(2-Pyridyl)piperazine
34803-66-2
$0.01
98%;99%
Career Henan Chemical Co

1-(2-Pyridyl)piperazine Spectrum

1-(2-Pyridyl)piperazine(34803-66-2)MS 1-(2-Pyridyl)piperazine(34803-66-2)¹HNMR 1-(2-Pyridyl)piperazine(34803-66-2)¹³CNMR 1-(2-Pyridyl)piperazine(34803-66-2)IR1 1-(2-Pyridyl)piperazine(34803-66-2)Raman

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1of4

2-pyridyl piperazine 1-(2-PYRIDYL)PIPERAZINE, 99.5+% 2-(1-piperazino)pyridine 2-piperazinopyridine 1-(Pyridin-2-yl)piperazine 98% N-(4-PYRIDYL) PIPERAZINE 1-PYRIDIN-2-YL-PIPERAZINE >98% 1-(2-Pyridyl)piperazine ,98% 1-pyridin-2-ylpiperazine(SALTDATA: FREE) 4-(2-Pyridinyl)piperazine 4-(2-Pyridyl)piperazine N-(2-Pyridyl)piperazine N-Pyridin-2-ylpiperazine NSC 137781 NSC 26624 2-(Piperazin-1-yl)pyridine 1-(2-Pyridyl)piperazine, 98% 25GR 1-(2-Pyridyl)piperazine, 98% 5GR 1-(2-Pyridyl)piperazine >=99% 1-(2-Pyridyl)piperazine 98% Piperazine, 1-(2-pyridinyl)- RARECHEM AH CK 0193 TIMTEC-BB SBB006445 2-(1-PIPERAZINYL)PYRIDINE 1-PYRIDIN-2-YL-PIPERAZINE 1-(2-PYRIDYL)PIPERAZINE 1-(2-PYRIDINYL)PIPERAZINE AKOS BBS-00003613 LABOTEST-BB LTBB000605 BUTTPARK 82\08-03 1-(2-Pyridyl)piperazine@2 mg/mL in Methylene chloride 1-(2-Pyridyl)piperazine> NSC13778 1-(pyridine-2-yl)piperazine 1-(pyridine)piperazine 1-(2-pyridine)piperazine 1-(2-Pyridyl)piperazine, ≥ 98.0% 34803-66-2 C9H13N3 Building Blocks Heterocyclic Building Blocks Piperazines Pharmaceuticals Piperidines, Piperidones, Piperazines pharmacetical API intermediates Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities