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4-Hydroxy-3-nitrobenzonitrile

4-Hydroxy-3-nitrobenzonitrile Structure
4-Hydroxy-3-nitrobenzonitrile structure
CAS No.
3272-08-0
Chemical Name:
4-Hydroxy-3-nitrobenzonitrile
Synonyms
2-NITRO-4-CYANOPHENOL;4-CYANO-2-NITROPHENOL;4-cyano-2-nitrophenolate;4-HYDROXY-3-NITROBENZONITRILE;3-Nitro-4-hydroxybenzonitrile;Benzonitrile, 4-hydroxy-3-nitro-;4-HYDROXY-3-NITROBENZONITRILE 97%;4-Hydroxy-3-nitrobenzonitrile,97%;4-BROMO-2,6-DIETHOXY-1-NITROBENZENE;4-Hydroxy-3-nitrobenzonitrile ISO 9001：2015 REACH
CBNumber:
CB7363601
Molecular Formula:
C7H4N2O3
Molecular Weight:
164.12
MDL Number:
MFCD00070775
MOL File:
3272-08-0.mol
MSDS File:
SDS
Last updated:2026-05-28 05:39:55
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4-Hydroxy-3-nitrobenzonitrile Properties

Melting point 146-148 °C (lit.)
Boiling point 291.56°C (rough estimate)
Density 1.5018 (rough estimate)
refractive index 1.5300 (estimate)
storage temp. Sealed in dry,Room Temperature
pka 4.66±0.14(Predicted)
Appearance Light yellow to yellow Solid
InChI InChI=1S/C7H4N2O3/c8-4-5-1-2-7(10)6(3-5)9(11)12/h1-3,10H
InChIKey INBLGVOPOSGVTA-UHFFFAOYSA-N
SMILES C(#N)C1=CC=C(O)C([N+]([O-])=O)=C1
CAS DataBase Reference 3272-08-0(CAS DataBase Reference)
FDA UNII PCQ4PKY4SY
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-37/39-36/37/39-24/25
WGK Germany  3
HS Code  29269090
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Hydroxy-3-nitrobenzonitrile price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 344575 4-Hydroxy-3-nitrobenzonitrile 98% 3272-08-0 25g $379 2026-04-30 Buy
Apolloscientific OR110136 4-Hydroxy-3-nitrobenzonitrile 97% 3272-08-0 100g $150 2026-06-04 Buy
AK Scientific J94096 2-Nitro-4-cyanophenol 95% 3272-08-0 5g $12 2026-06-04 Buy
AK Scientific J94096 2-Nitro-4-cyanophenol 95% 3272-08-0 25g $34 2026-06-04 Buy
AK Scientific J94096 2-Nitro-4-cyanophenol 95% 3272-08-0 100g $125 2026-06-04 Buy
Product number Packaging Price Buy
344575 25g $379 Buy
OR110136 100g $150 Buy
J94096 5g $12 Buy
J94096 25g $34 Buy
J94096 100g $125 Buy

4-Hydroxy-3-nitrobenzonitrile Chemical Properties,Uses,Production

Chemical Properties

yellow powder

Uses

4-Hydroxy-3-nitrobenzonitrile may be used in the synthesis of:

  • 3-azido-4-methoxybenzonitrile
  • 4-methoxy-3-nitrobenzonitrile
  • ethyl [2,2-dimethyl-6-(Δ2-thiazolin-2-yl)-4H-l,4-benzoxazin-3-one-4-yl]butyrate

General Description

4-Hydroxy-3-nitrobenzonitrile is one of the main photoproduct formed during hotolytic destruction of herbicide bromoxynil.

Synthesis

4-Hydroxy-3-nitrobenzaldehyde

3011-34-5

4-Hydroxy-3-nitrobenzonitrile

3272-08-0

General procedure for the synthesis of 4-hydroxy-3-nitrobenzonitrile from 4-hydroxy-3-nitrobenzaldehyde: Aromatic aldehyde 1 (0.500 mmol, 1.0 eq.) and trimethylsilyl azide (TMSN3; 115 mg, 1.00 mmol, 2.0 eq.) were dissolved in a pre-mixed solvent mixture of hexafluoroisopropanol (HFIP) and acetonitrile (ACN) (2.0 mL, 1:1 volume ratio) in two dram vials, which was carried out under nitrogen protection. Subsequently, trifluoromethanesulfonic acid (TfOH; 17.7 μL, 0.200 mmol, 0.40 eq.) was added to the reaction system, and exothermic and rapid foaming phenomena due to gas production were immediately observed. The vial was quickly capped and the reaction mixture was stirred at room temperature for 20 to 75 min. Upon completion of the reaction, the reaction mixture was concentrated under a stream of nitrogen. The residue obtained was suspended in a solvent mixture of dichloromethane (CH2Cl2) and hexane and this suspension was upsampled into a cartridge containing 5 g silica gel. Purification was carried out by normal-phase silica gel fast column chromatography using a CombiFlash purification system, and suitable fractions were collected and concentrated to give the target product, aromatic nitrile 2.

References

[1] Journal of Organic Chemistry, 2012, vol. 77, # 12, p. 5364 - 5370
[2] Molecules, 2016, vol. 21, # 1,
[3] Patent: US5614520, 1997, A

4-Hydroxy-3-nitrobenzonitrile Preparation Products And Raw materials

Raw materials

4-Fluoro-3-nitrobenzonitrile 4-Chloro-3-nitrobenzamide 4-Chloro-3-nitrobenzonitrile 4-Hydroxy-3-nitrobenzaldehyde 4-Cyanophenol
Salicylhydroxamic acid Acetonitrile Trifluoromethanesulfonic acid Azidotrimethylsilane

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Preparation Products

4-Hydroxy-3-nitrobenzonitrile Suppliers

Global( 152)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhongke Pingsheng (Dalian) New Materials Co., Ltd. 18841123239 1798136513@qq.com China 128 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Supplier Advantage
Zhongke Pingsheng (Dalian) New Materials Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
Energy Chemical 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Shanghai Longsheng chemical Co.,Ltd. 59

View Lastest Price from 4-Hydroxy-3-nitrobenzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Hydroxy-3-nitrobenzonitrile pictures 2026-09-02 4-Hydroxy-3-nitrobenzonitrile
3272-08-0
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Hydroxy-3-nitrobenzonitrile pictures 2026-06-30 4-Hydroxy-3-nitrobenzonitrile
3272-08-0
 1KG 98 10000KGS Shaanxi Dideu New Materials Co. Ltd
4-Hydroxy-3-nitrobenzonitrile pictures 2020-02-01 4-Hydroxy-3-nitrobenzonitrile
3272-08-0
 $1.00 1KG 99% 200kgs Career Henan Chemical Co

4-Hydroxy-3-nitrobenzonitrile Spectrum

4-Hydroxy-3-nitrobenzonitrile(3272-08-0)1HNMR4-Hydroxy-3-nitrobenzonitrile(3272-08-0)IR4-Hydroxy-3-nitrobenzonitrile(3272-08-0)Raman

3272-08-0(4-Hydroxy-3-nitrobenzonitrile)Related Search:

Benzonitrile 3-Hydroxypyridine p-Tolunitrile 3-Nitrotoluene 2-Cyanophenol
4-Nitrobenzonitrile Chlorophosphonazo III 4-Nitrophenol Nitrophenol Nitrobenzene
Nitroxinil 2-NITRO-4-CYANOPHENOL 3-bromo-4-hydroxy-5-nitrobenzonitrile 2-Nitrophenol 3-Nitrobenzonitrile
4-Methoxy-3-nitrobenzonitrile 3-Nitrobenzonitrile 4-Cyanophenol

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4-CYANO-2-NITROPHENOL 4-HYDROXY-3-NITROBENZONITRILE 2-NITRO-4-CYANOPHENOL 4-HYDROXY-3-NITROBENZONITRILE / 2-NITRO-4-CYANOPHENOL 4-HYDROXY-3-NITROBENZONITRILE 97% Benzonitrile, 4-hydroxy-3-nitro- 3-Nitro-4-hydroxybenzonitrile 4-BROMO-2,6-DIETHOXY-1-NITROBENZENE 4-Hydroxy-3-nitrobenzonitrile,97% 4-Hydroxy-3-nitrobenzonitrile4-Cyano-2-nitrophenol 4-cyano-2-nitrophenolate 4-Hydroxy-3-nitrobenzonitrile ISO 9001：2015 REACH 3272-08-0 HOC6H3NO2CN C6 to C7 C7 Carbonyl Compounds Carboxylic Acids Building Blocks Nitrogen Compounds Organic Building Blocks Cyanides/Nitriles Aromatic Building Blocks C6 to C7 Cyanides/Nitriles Nitrogen Compounds Phenoles and thiophenoles Aromatic Nitriles Building Blocks C6 to C7 Chemical Synthesis Nitrogen Compounds Organic Building Blocks