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TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE structure

CAS No.: 85006-25-3

Chemical Name:: TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE

Synonyms: DBNOH;oxycarbamate;Einecs 285-055-0;AKOS BBS-00000383;N,O-DI-BOC-HYDROXYLAMINE;N,O-BIS-BOC-HYDROXYLAMINE;N,O-Di-BOC-hydroxylamine,97%;tert-Butyl (tert-butoxycarbonyl);N,O-Di-Boc-hydroxylamine;N,O-BIS(TERT-BUTOXYCARBONYL)HYDROXYLAMINE

CBNumber:: CB3431205

Molecular Formula:: C10H19NO5

Molecular Weight:: 233.26

MDL Number:: MFCD00034797

MOL File:: 85006-25-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:54

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TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE Properties

Melting point	67-70 °C(lit.)
Density	1.080
storage temp.	-20°C
form	powder to crystal
color	White to Almost white
BRN	1794022
CAS DataBase Reference	85006-25-3
FDA UNII	HX6G035C2M
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	10-21
HS Code	29241900

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	412791	N,O-Di-Boc-hydroxylamine 97%	85006-25-3	5g	$72.8	2025-07-31	Buy
Sigma-Aldrich	412791	N,O-Di-Boc-hydroxylamine 97%	85006-25-3	1g	$35	2023-06-20	Buy
TCI Chemical	B4780	N,O-Bis(tert-butoxycarbonyl)hydroxylamine >98.0%(GC)	85006-25-3	1g	$27	2025-07-31	Buy
TCI Chemical	B4780	N,O-Bis(tert-butoxycarbonyl)hydroxylamine >98.0%(GC)	85006-25-3	5g	$76	2025-07-31	Buy
TRC	B700648	tert-Butyl(tert-Butoxycarbonyl)oxycarbamate	85006-25-3	100mg	$60	2021-12-16	Buy

Product number	Packaging	Price	Buy
412791	5g	$72.8	Buy
412791	1g	$35	Buy
B4780	1g	$27	Buy
B4780	5g	$76	Buy
B700648	100mg	$60	Buy

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE Chemical Properties,Uses,Production

Chemical Properties

White crystalline powder

Uses

N,O-Di-Boc-hydroxylamine (N,O-Bis(tert-butoxycarbonyl)hydroxylamine) may be used for the synthesis of the following:

5-lipoxygenase inhibitor LY280810
hydroxylamines
hydroxamic acids,

Synthesis Reference(s)

Journal of the American Chemical Society, 81, p. 955, 1959 DOI: 10.1021/ja01513a049
Tetrahedron Letters, 34, p. 7043, 1993 DOI: 10.1016/S0040-4039(00)61592-7

Synthesis

24424-99-5

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE

85006-25-3

The general procedure for the synthesis of N,O-di-BOC-hydroxylamine from di-tert-butyl dicarbonate was as follows: first, hydroxylamine hydrochloride (550.0 g, 7.9 mol) was dissolved in a solvent mixture of water (5.5 L) and heptane/MTBE (5:1, 5.5 L), and the mixture was cooled to -5 °C. Subsequently, a solution of di-tert-butyl dicarbonate (3.55 Kg, 16.3 mol) and triethylamine (1.67 Kg, 16.5 mol) in heptane/MTBE (5:1, 1.1 L), which was pre-cooled to -5°C, was slowly added dropwise to the above mixture, and the dropwise process lasted for more than 2 hours. The reaction mixture was continued to be stirred at -5°C for 1 hour, then gradually warmed up to room temperature and stirred overnight. Upon completion of the reaction, the organic layer and the aqueous layer were separated, and the organic layer was washed twice with saturated aqueous ammonium chloride solution (2 L) and saturated aqueous sodium chloride solution (1 L) sequentially, then dried with anhydrous sodium sulfate, filtered and concentrated to obtain an oily product, which was converted to a white solid by crystallization. Finally, the resulting solid was stirred with heptane (1 L) in an ice-water bath and filtered to afford the target product N,O-dibOC-hydroxylamine (1360.2 g, 73% yield). The structure of the product was confirmed by 1H NMR (d6-DMSO) with characteristic peaks located at δ 10.7 (broad single peak, 1H), 1.44 (single peak, 9H), 1.40 (single peak, 9H).

References

[1] Tetrahedron Letters, 1993, vol. 34, # 44, p. 7043 - 7044
[2] Journal of the Chemical Society - Perkin Transactions 1, 1998, # 20, p. 3471 - 3478
[3] Journal of Organic Chemistry, 2009, vol. 74, # 1, p. 254 - 263
[4] Patent: WO2014/66132, 2014, A1. Location in patent: Page/Page column 19
[5] Patent: WO2015/138208, 2015, A1. Location in patent: Page/Page column 7

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE synthesis

Synthesis of TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE from Di-tert-butyl dicarbonate and Hydroxylamine hydrochloride

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE Preparation Products And Raw materials

Raw materials

tert-Butyl N-hydroxycarbamate Hydroxylamine hydrochloride Di-tert-butyl dicarbonate tert-butyl azidoformate Water

tert-Butyl carbazate Triethylamine tert-Butyl methyl ether Heptane

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Preparation Products

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE Suppliers

Global( 113)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2930	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8826	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
CD Chemical Group Limited	+8615986615575	info@codchem.com	China	20342	58
changzhou huayang technology co., ltd	+8615250961469	2571773637@qq.com	China	9647	58

Supplier	Advantage
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
CD Chemical Group Limited	58
changzhou huayang technology co., ltd	58

View Lastest Price from TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE 85006-25-3	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2019-07-06	TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE 85006-25-3	US $1.00 / KG	1KG	98%	1ton	Career Henan Chemical Co

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE
85006-25-3
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE
85006-25-3
US $1.00 / KG
98%
Career Henan Chemical Co

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE Spectrum

TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE(85006-25-3)¹HNMR TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE(85006-25-3)FT-IR TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE(85006-25-3)IR

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TERT-BUTYL N-(TERT-BUTOXYCARBONYLOXY)CARBAMATE N,O-DI-BOC-HYDROXYLAMINE N,O-BIS-BOC-HYDROXYLAMINE N,O-BIS(TERT-BUTOXYCARBONYL)HYDROXYLAMINE (tert-butoxycarbonylamino) tert-butyl carbonate tert-butyl [(2-methylpropan-2-yl)oxycarbonylamino] carbonate carbonic acid (tert-butoxycarbonylamino) tert-butyl ester carbonic acid [(tert-butoxy-oxomethyl)amino] tert-butyl ester oxycarbamate tert-Butyl (tert-butoxycarbonyl) DBNOH N,O-Bis(tert-butoxycarbonyl)hydroxylamine≥ 98%(GC) N,O-Bis(tert-butoxycarbonyl)hydroxylamine [[(1,1-Dimethylethoxy)carbonyl]oxy]carbamic acid 1,1-dimethylethyl ester Carbonic acid tert-butyl(tert-butoxycarbonylamino) ester N,O-Di-BOC-hydroxylamine,97% Einecs 285-055-0 N,O-Bis-(tert-Butyloxycarbonyl)hydroxylamine [(tert-Butoxycarbonyl)oxy]carbamic acid tert-butyl ester Carbonic acid [[(1,1-dimethylethoxy)carbonyl]azanyl] 1,1-dimethylethyl ester tert-Butyl (tert-butoxycarbonyloxy)carbamate O-(tert-Butoxycarbonyl)hydroxylamine, N-BOC protected, N,O-Bis(tert-butoxycarbonyl)hydroxylamine AKOS BBS-00000383 tert-butyl [[(1,1-dimethylethoxy)carbonyl]oxy]carbamate N,O-Bis(tert-butoxycarbonyl)hydroxylamine, tert-Butyl N-(tert-butoxycarbonyloxy)carbamate N,O-Bis(tert-butoxycarbonyl)hydroxylamine> N-(tert-Butoxycarbonyloxy)carbamic Acid tert-Butyl Ester N,O-Di-Boc-hydroxylamine 85006-25-3 CH33COCONHOCOOCCH33 Protected Amines Hydroxylamines Nitrogen Compounds Organic Building Blocks Building Blocks Building Blocks Chemical Synthesis Nitrogen Compounds Organic Building Blocks Protected Amines