2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide
- CAS No.
- 1201652-50-7
- Chemical Name:
- 2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide
- Synonyms
- Retro-2, 10 mM in DMSO;2-{[(5-methyl-2-thienyl)methylene]amino};2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide;(E)-2-(((5-Methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide;Benzamide, 2-[(E)-[(5-methyl-2-thienyl)methylene]amino]-N-phenyl-;2-{[(E)-(5-methylthiophen-2-yl)methylidene]amino}-N-phenylbenzamide;LC3-II,inhibit,Inhibitor,Retro-2,retrograde,Shiga-like,Golgi,Filovirus,toxins,Retro2,GFP-LC3,trafficking,Autophagy,Parasite
- CBNumber:
- CB73768667
- Molecular Formula:
- C19H16N2OS
- Molecular Weight:
- 320.41
- MDL Number:
- MFCD01042512
- MOL File:
- 1201652-50-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) | ![]() GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BYB65250 | 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide | 1201652-50-7 | 25mg | $806 | 2026-06-04 | Buy |
| Biosynth | BYB65250 | 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide | 1201652-50-7 | 50mg | $1290.5 | 2026-06-04 | Buy |
| Biosynth | BYB65250 | 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide | 1201652-50-7 | 100mg | $1794 | 2026-06-04 | Buy |
| ChemScene | CS-0087101 | Retro-2 98.0% | 1201652-50-7 | 1mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0087101 | Retro-2 98.0% | 1201652-50-7 | 5mg | $184 | 2026-06-04 | Buy |
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Chemical Properties, Uses, Production
Uses
Retro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy[1][2][3].
in vivo
Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge[1].
| Animal Model: | Female Balb/c mice (Pathogen-free 6-week-old) injected with ricin (2 μg/kg)[1] |
| Dosage: | 2 mg/kg, 10 mg/kg, 20 mg/kg, 200 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 21 days |
| Result: | Protected mice against ricin challenge. |
IC 50
Leishmania; EBOV
References
[1] Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. DOI:10.1016/j.cell.2010.01.043
[2] Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464. DOI:10.3389/fcell.2020.00464
[3] Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163. DOI:10.1016/j.antiviral.2017.11.016
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alinda Chemical Ltd. | +7 (495) 672-17-08 | sale@alinda.ru | Russia | 68136 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9778 | 55 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |






