4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
- CAS No.
- 39143-25-4
- Chemical Name:
- 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
- Synonyms
- 4-Amino-1-benzyl-4-carboxypiperidine;4-Amino-1-benzylpiperidine-4-carboxylic;N'-(3,4-dichlorophenyl)propane-1,6-diamine;1-Benzyl-4-amino-4-piperidinecarboxylic acid;4-AMINO-1-BENZYL-4-PIPERIDINECARBOXYLIC ACID;4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID;4-Amino-1-(phenylmethyl)-4-piperidinecarboxylic acid;4-Piperidinecarboxylic acid, 4-aMino-1-(phenylMethyl)-
- CBNumber:
- CB7407620
- Molecular Formula:
- C13H18N2O2
- Molecular Weight:
- 234.29
- MDL Number:
- MFCD00794952
- MOL File:
- 39143-25-4.mol
| Melting point | 247-248° |
|---|---|
| Boiling point | 385.7±42.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 1.73±0.20(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C13H18N2O2/c14-13(12(16)17)6-8-15(9-7-13)10-11-4-2-1-3-5-11/h1-5H,6-10,14H2,(H,16,17) |
| InChIKey | UAPJXCZSNCQLMR-UHFFFAOYSA-N |
| SMILES | N1(CC2=CC=CC=C2)CCC(N)(C(O)=O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Risk Statements | 36 |
| Safety Statements | 26 |
| HS Code | 2933399990 |
4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A593955 | 4-Amino-1-benzyl-piperidine-4-carboxylicacid | 39143-25-4 | 500mg | $145 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA147476 | 4-Amino-1-benzyl-piperidine-4-carboxylicacid | 39143-25-4 | 250mg | $70 | 2021-12-16 | Buy |
| ChemScene | CS-W006436 | 4-Amino-1-benzylpiperidine-4-carboxylicacid >98.0% | 39143-25-4 | 1g | $75 | 2021-12-16 | Buy |
| Apolloscientific | OR480328 | 4-Amino-1-benzyl-piperidine-4-carboxylicacid 95% | 39143-25-4 | 1g | $76 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA147476 | 4-Amino-1-benzyl-piperidine-4-carboxylicacid | 39143-25-4 | 1g | $208 | 2021-12-16 | Buy |
4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Chemical Properties,Uses,Production
Synthesis
![8-BENZYL-1,3,8-TRIAZASPIRO[4.5]DECANE-2,4-DIONE](/StructureFile/ChemBookStructure3/GIF/CB9137202.gif)
28936-94-9
39143-25-4
The general procedure for the synthesis of 1-benzyl-4-amino-4-piperidinecarboxylic acid using 8-benzyl-2,4-dioxo-1,3,8-triazaspiro[4,5]decane as a starting material was as follows: 2.4 kg of sodium hydroxide was dissolved in 10 L of deionized water in a 20 L reactor. Subsequently, 614 g of 8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (1.38) was added to this solution to form a reaction suspension. The suspension was heated to 80°C. After reaching 80°C, the temperature was gradually increased at a rate of 10°C per step. When the temperature was raised to 105°C, the reaction mixture began to foam vigorously. The reaction was maintained at 108°C with continuous stirring overnight. Upon completion of the reaction, the mixture was cooled to 10 °C, and 5 L of concentrated hydrochloric acid was slowly added dropwise to adjust the pH to 7-8. During the dropwise addition, the reaction temperature was controlled to be no more than 23 °C. A solid was precipitated from the reaction solution and the precipitate was collected by filtration. The resulting solid was dried under vacuum at 40 °C for 3 days, followed by drying at 80 °C overnight to give 469.7 g of 1-benzyl-4-amino-4-piperidinecarboxylic acid (I.39) in a final yield of 85% of the theoretical value.
References
[1] Patent: WO2012/101013, 2012, A1. Location in patent: Page/Page column 97; 98
[2] Patent: US2013/23502, 2013, A1. Location in patent: Paragraph 0266; 0269-0270
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3972 - 3983
[4] Patent: WO2016/78771, 2016, A1. Location in patent: Page/Page column 134
4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 | sales@zjgoldpharm.com | China | 5899 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
View Lastest Price from 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-25 | 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
39143-25-4
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
39143-25-4
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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