Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1,8-Diamino-3,6-dioxaoctane

1,8-Diamino-3,6-dioxaoctane

1,8-Diamino-3,6-dioxaoctane Structure
1,8-Diamino-3,6-dioxaoctane structure
CAS No.
929-59-9
Chemical Name:
1,8-Diamino-3,6-dioxaoctane
Synonyms
2,2'-(Ethane-1,2-diylbis(oxy))bis(ethan-1-amine);NH2-PEG2-NH2;1,2-BIS(2-AMINOETHOXY)ETHANE;2,2'-(Ethylenedioxy)bis(ethylamine);2,2'-(ethane-1,2-diylbis(oxy))diethanamine;EDR-148;2-[2-(2-aminoethoxy)ethoxy]ethanamine;2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;Amino-PEG2-Amine;1,2-Bis(2-aMinoethoxy)ethane, 98%, 98%
CBNumber:
CB7408955
Molecular Formula:
C6H16N2O2
Molecular Weight:
148.2
MDL Number:
MFCD00040474
MOL File:
929-59-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:06:23
Product description Number Pack Size Price
1,8-Diamino-3,6-dioxaoctane for synthesis 8.18116 25mL $34.6
1,8-Diamino-3,6-dioxaoctane for synthesis 8.18116 100mL $82.9
2,2′-(Ethylenedioxy)bis(ethylamine) 98% 385506 100ml $100
2,2′-(Ethylenedioxy)bis(ethylamine) 98% 385506 5l $1630
1,2-Bis(2-aminoethoxy)ethane >98.0%(GC)(T) B1431 25g $24
More product size
Request For Quotation

1,8-Diamino-3,6-dioxaoctane Properties

Boiling point 105-109 °C6 mm Hg(lit.)
Density 1.015 g/mL at 25 °C(lit.)
vapor pressure 71Pa at 20℃
refractive index n20/D 1.461(lit.)
Flash point >230 °F
storage temp. Store below +30°C.
solubility soluble in Dimethylformamide, Methanol
form Liquid
pka 9.04±0.10(Predicted)
color Colorless to Almost colorless
Water Solubility Soluble in 0.4 parts water.
Sensitive Hygroscopic
BRN 1739187
Cosmetics Ingredients Functions NOT REPORTED
InChI 1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2
InChIKey IWBOPFCKHIJFMS-UHFFFAOYSA-N
SMILES NCCOCCOCCN
CAS DataBase Reference 929-59-9(CAS DataBase Reference)
FDA UNII R41ZT4UF34
EPA Substance Registry System Ethanamine, 2,2'-[1,2-ethanediylbis(oxy)]bis- (929-59-9)
UNSPSC Code 12352116
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302-H314-H317-H334
Precautionary statements  P261-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  C
Risk Statements  22-34-42/43-37
Safety Statements  23-26-36/37/39-45
RIDADR  UN 2735 8/PG 2
WGK Germany  3
F  34
TSCA  TSCA listed
HazardClass  8
PackingGroup  III
HS Code  29221990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Resp. Sens. 1
Skin Corr. 1B
Skin Sens. 1
REACH Registrations Active
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
0
1 0

1,8-Diamino-3,6-dioxaoctane price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18116 1,8-Diamino-3,6-dioxaoctane for synthesis 929-59-9 25mL $34.6 2026-04-30 Buy
Sigma-Aldrich 8.18116 1,8-Diamino-3,6-dioxaoctane for synthesis 929-59-9 100mL $82.9 2026-04-30 Buy
Sigma-Aldrich 385506 2,2′-(Ethylenedioxy)bis(ethylamine) 98% 929-59-9 100ml $100 2026-04-30 Buy
Sigma-Aldrich 385506 2,2′-(Ethylenedioxy)bis(ethylamine) 98% 929-59-9 5l $1630 2026-04-30 Buy
TCI Chemical B1431 1,2-Bis(2-aminoethoxy)ethane >98.0%(GC)(T) 929-59-9 25g $24 2026-04-30 Buy
Product number Packaging Price Buy
8.18116 25mL $34.6 Buy
8.18116 100mL $82.9 Buy
385506 100ml $100 Buy
385506 5l $1630 Buy
B1431 25g $24 Buy

1,8-Diamino-3,6-dioxaoctane Chemical Properties,Uses,Production

Description

Amino-PEG2-Amine is a crosslinker containing two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2,2'-(Ethylenedioxy)bis(ethylamine) is used to linker to form conjugates of manganese-doped zinc sulfide nanoparticles with folic acid.

Application

1,8-Diamino-3,6-dioxaoctane is a chelating agent that has been shown to have antibacterial efficacy against gram-positive bacteria. It has been demonstrated to bind to a variety of functionalities such as amines, low energy metals, and hydroxy groups. It has been studied in the synthesis of coordination complexes with a range of geometric structures. The synthesis methods for this compound include solid-phase synthesis and hydrolysis of ethylenediamine. This compound has also been used as an electron donor in fluorescence techniques and morphology studies.

Definition

ChEBI: Ethylene glycol bis(2-aminoethyl) ether is an ether.

Flammability and Explosibility

Not classified

Synthesis

Step 1, Synthesis of 1,6-dicyano-2,5-dioxohexane

Sodium hydride (88 g, 2.2 mol) and tetrahydrofuran were added to a 5L three-necked flask, and cooled to 0 C in an ice bath. A tetrahydrofuran solution of ethylene glycol (62.07 g, 1 mol) was added dropwise. Then the reaction was naturally raised to room temperature for 4h, then the ice bath was cooled down to 0C and a tetrahydrofuran solution of bromoacetonitrile (239.9g, 2.0 mol) was added dropwise to the reaction solution, which was naturally raised to room temperature after dropping, and the reaction was continued for 18h (overnight), and the reaction was stopped when mono-substituted impurities were monitored to be almost consumed by TLC. The reaction solution was cooled down and quenched with methanol, and a small amount of silica gel and diatomaceous earth was spread in a Brinell's funnel to filter the reaction solution, which was concentrated to obtain 113.5 g of 111,6-dicyano-2,5-dioxahexane in 81% yield.

Step 2, Synthesis of 1,8-diamino-3,6-dioxaoctane

1,6-dicyano-2,5-dioxohexane (100 g, 0.71 mol), 1 L of methanol, and Pd/C (25 g, 25%) were placed in a 2 L three-neck flask. Then hydrogen was passed into the reaction solution until the end of the reaction, and then the hydrogen was stopped. After filtration and concentration, crude 1,8-diamino-3,6-dioxaoctane was obtained, and 79.3 g of pure 1,8-diamino-3,6-dioxaoctane was obtained after distillation under reduced pressure in 75% yield.

1,8-Diamino-3,6-dioxaoctane synthesis

80322-82-3
929-59-9
Synthesis of 1,8-Diamino-3,6-dioxaoctane from Triethylene Glycol Dimethanesulfonate

1,8-Diamino-3,6-dioxaoctane Preparation Products And Raw materials

Raw materials

2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL Acetonitrile, 2,2'-[1,2-ethanediylbis(oxy)]bis- (9CI) 1H-Isoindole-1,3(2H)-dione,2,2'-[1,2-ethanediylbis(oxy-2,1-ethanediyl)]bis- (9CI) Ethane, 1,2-bis(2-bromoethoxy)- Triethylene Glycol Dimethanesulfonate
Tri(Ethylene Glycol) DI-P-Toluenesulfonate Diazinon 1,8-Diazido-3,5-dioxaoctane 1,2-Bis(2-chloroethoxy)ethane

1of2

Preparation Products

Ethylenebis(oxyethylenenitrilo)tetraacetic acid Boc-1-amino-3,6-dioxa-8-octanediamine 2-[2-(2-Azidoethoxy)ethoxy]ethanamine 1,4,10,13-Tetraoxa-7,16-diazacyclooctadecane, 2-[(2-propen-1-yloxy)methyl]-

1,8-Diamino-3,6-dioxaoctane Suppliers

Global( 272)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5229 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21587 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Richest Group Ltd 		18017061086 oled@richest-group.com CHINA 5600 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9542 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
Wuhan Borenpharm Co., Ltd 		027-65563561 18717150066 3207347307@qq.com CHINA 1238 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Richest Group Ltd 		58
Fuxin Pharmaceutical 		58
Antai Fine Chemical Technology Co.,Limited 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
Wuhan Borenpharm Co., Ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58

View Lastest Price from 1,8-Diamino-3,6-dioxaoctane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1, 8-Diamino-3, 6-Dioxaoctane pictures 2026-05-28 1, 8-Diamino-3, 6-Dioxaoctane
929-59-9
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD
Bis-NH2-PEG2 pictures 2026-04-21 Bis-NH2-PEG2
929-59-9
 10g TargetMol Chemicals Inc.
2,2'-(ethane-1,2-diylbis(oxy))bis(ethan-1-amine) pictures 2026-02-05 2,2'-(ethane-1,2-diylbis(oxy))bis(ethan-1-amine)
929-59-9
 1g 98% 1g/bottle, 10g/bottle, 100g/bottle XIAMEN SINOPEG BIOTECH CO., LTD.

1,8-Diamino-3,6-dioxaoctane Spectrum

1,8-Diamino-3,6-dioxaoctane(929-59-9)MS1,8-Diamino-3,6-dioxaoctane(929-59-9)1HNMR1,8-Diamino-3,6-dioxaoctane(929-59-9)13CNMR1,8-Diamino-3,6-dioxaoctane(929-59-9)IR11,8-Diamino-3,6-dioxaoctane(929-59-9)Raman

929-59-9(1,8-Diamino-3,6-dioxaoctane)Related Search:

4,4'-Diaminodiphenylsulfone 4,4'-Methylenedianiline Iminodiacetic acid 1,3-Diaminoguanidine monohydrochloride Iminodiacetonitrile
Ethylamine Lithium diisopropylamide 1,4,10-TRIOXA-7,13-DIAZACYCLOPENTADECANE Ethylenebis(oxyethylenenitrilo)tetraacetic acid 4,13-Diaza-18-crown 6-ether
2,2'-BIS(2-OXAZOLINE) Kryptofix 222 DIHYDROSTREPTOMYCIN SESQUISULFATE SALT Streptomycin sulfate ETH 1001
KRYPTOFIX(R) 221 2-2-(2-Aminophenoxy)ethoxyaniline Diethylamine

1of4

2,2’-[1,2-ethanediylbis(oxy)bis-ethanamin 1,8-DIAMINO-3,6-DIOXAOCTANE NSC 28972 1,8-Diamino-3,6-dioxaoctane Ethylene Glycol Bis(2-aminoethyl) Ether 1,8-DiaMino-3,6-dioxaoCLane 1,8-DIAMINO-3,6-DIOXAOCTANE FOR SYNTHESI 2-[2-(2-AMino-ethoxy)-ethoxy]-ethylaMine 1,8-Diamino-3,6-dioxaoctane, 2,2'-(Ethylenedioxy)diethylamine, 1,2-Bis(2-aminoethoxy)ethane 3,6-Dioxaoctane-1,8-diamine 98% (PEO)3-bis-aMine 1,2-Bis(2-aMinoethoxy)ethane, 98%, 98% 2,2'-(Ethylenedioxy)bis(ethylamine) purum, >=96.0% (GC) 3,6-dioxa-1,8-diaminooctane ETHYLENE GLYCOL BIS(2-AMINOETHYL) ETHER Amino-PEG2-Amine 1,8-Diamino-3,6-dioxaoctane for synthesis 3,6-dioxaoctamethylenediamine Ethanamine, 2,2-1,2-ethanediylbis(oxy)bis- 2,2'-(Ethylenedioxy)bis(ethylamine), 97+% 1,2-Bis(2-aminoethoxy)ethane, 1,8-Diamino-3,6-dioxaoctane, 2,2μ-(Ethylenedioxy)diethylamine DA -10 Jeffamine EDR-148 1,8-Diamino-3,6-dioxaoctane,98% 2,2′-(Ethylenedioxy)bis(ethylamine),1,2-Bis(2-aminoethoxy)ethane, 1,8-Diamino-3,6-dioxaoctane, 2,2′-(Ethylenedioxy)diethylamine TRIETHYLENEGLYCOLDIAMINE 1,8-DiaMino-3,6-dioxaoctane, 98% 5GR 2,2'-[1,2-Ethanediylbis(oxy)]bis-ethanaMine 1,2-Bis(2-aminoethoxy)ethane > PROTAC Linker 19 8-Diamino-3,6-dioxaoctane 3,6-Dioxaoctane-1,8-diamine 2,2-(Ethylenedioxy)bis(ethylamine) 2,2'-(Ethylenedioxy)bis(ethanamine) 1,8-DIAMINO-3,6-D 1,8-DiaMino-3,6-dioxaoCLaneChemicalbook Aminotriethylene Glycolamine 1,2-BIS(2-AMINOETHOXY)ETHANE 2,2'-(Ethane-1,2-diylbis(oxy))bis(ethan-1-amine) 2,2'-(ETHYLENEDIOXY)DIETHYLAMINE 2,2'-(ethane-1,2-diylbis(oxy))diethanamine 2,2'-(Ethylenedioxy)bis(ethylamine) 2-[2-(2-aMinoethoxy)ethoxy]ethan-1-aMine 2-[2-(2-aminoethoxy)ethoxy]ethanamine EDR-148 NH2-PEG2-NH2 Amine-PEG2-amine 929-59-9 C6H16N2O2 CH2OCH2CH2NH22 NH2CH2CH2OCH2CH2OCH2CH2NH2 Nitrogen Compounds Organic Building Blocks C2 to C6 Amines Building Blocks Aliphatics Amines PROTAC LINKER