1,8-Diamino-3,6-dioxaoctane
- CAS No.
- 929-59-9
- Chemical Name:
- 1,8-Diamino-3,6-dioxaoctane
- Synonyms
- 2,2'-(Ethane-1,2-diylbis(oxy))bis(ethan-1-amine);NH2-PEG2-NH2;1,2-BIS(2-AMINOETHOXY)ETHANE;2,2'-(Ethylenedioxy)bis(ethylamine);2,2'-(ethane-1,2-diylbis(oxy))diethanamine;EDR-148;2-[2-(2-aminoethoxy)ethoxy]ethanamine;2,2'-(ETHYLENEDIOXY)DIETHYLAMINE;Amino-PEG2-Amine;1,2-Bis(2-aMinoethoxy)ethane, 98%, 98%
- CBNumber:
- CB7408955
- Molecular Formula:
- C6H16N2O2
- Molecular Weight:
- 148.2
- MDL Number:
- MFCD00040474
- MOL File:
- 929-59-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 105-109 °C6 mm Hg(lit.) |
|---|---|
| Density | 1.015 g/mL at 25 °C(lit.) |
| vapor pressure | 71Pa at 20℃ |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | soluble in Dimethylformamide, Methanol |
| form | Liquid |
| pka | 9.04±0.10(Predicted) |
| color | Colorless to Almost colorless |
| Water Solubility | Soluble in 0.4 parts water. |
| Sensitive | Hygroscopic |
| BRN | 1739187 |
| InChI | 1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2 |
| InChIKey | IWBOPFCKHIJFMS-UHFFFAOYSA-N |
| SMILES | NCCOCCOCCN |
| CAS DataBase Reference | 929-59-9(CAS DataBase Reference) |
| FDA UNII | R41ZT4UF34 |
| EPA Substance Registry System | Ethanamine, 2,2'-[1,2-ethanediylbis(oxy)]bis- (929-59-9) |
| UNSPSC Code | 12352116 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314-H317-H334 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 22-34-42/43-37 | |||||||||
| Safety Statements | 23-26-36/37/39-45 | |||||||||
| RIDADR | UN 2735 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 34 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29221990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Resp. Sens. 1 Skin Corr. 1B Skin Sens. 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
1,8-Diamino-3,6-dioxaoctane price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.18116 | 1,8-Diamino-3,6-dioxaoctane for synthesis | 929-59-9 | 25mL | $34.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.18116 | 1,8-Diamino-3,6-dioxaoctane for synthesis | 929-59-9 | 100mL | $82.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 385506 | 2,2′-(Ethylenedioxy)bis(ethylamine) 98% | 929-59-9 | 100ml | $100 | 2026-04-30 | Buy |
| Sigma-Aldrich | 385506 | 2,2′-(Ethylenedioxy)bis(ethylamine) 98% | 929-59-9 | 5l | $1630 | 2026-04-30 | Buy |
| TCI Chemical | B1431 | 1,2-Bis(2-aminoethoxy)ethane >98.0%(GC)(T) | 929-59-9 | 25g | $24 | 2026-04-30 | Buy |
1,8-Diamino-3,6-dioxaoctane Chemical Properties, Uses, Production
Description
Amino-PEG2-Amine is a crosslinker containing two amino groups. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
2,2'-(Ethylenedioxy)bis(ethylamine) is used to linker to form conjugates of manganese-doped zinc sulfide nanoparticles with folic acid.
Application
1,8-Diamino-3,6-dioxaoctane is a chelating agent that has been shown to have antibacterial efficacy against gram-positive bacteria. It has been demonstrated to bind to a variety of functionalities such as amines, low energy metals, and hydroxy groups. It has been studied in the synthesis of coordination complexes with a range of geometric structures. The synthesis methods for this compound include solid-phase synthesis and hydrolysis of ethylenediamine. This compound has also been used as an electron donor in fluorescence techniques and morphology studies.
Definition
ChEBI: Ethylene glycol bis(2-aminoethyl) ether is an ether.
Flammability and Explosibility
Not classified
Synthesis
Step 1, Synthesis of 1,6-dicyano-2,5-dioxohexane
Sodium hydride (88 g, 2.2 mol) and tetrahydrofuran were added to a 5L three-necked flask, and cooled to 0 C in an ice bath. A tetrahydrofuran solution of ethylene glycol (62.07 g, 1 mol) was added dropwise. Then the reaction was naturally raised to room temperature for 4h, then the ice bath was cooled down to 0C and a tetrahydrofuran solution of bromoacetonitrile (239.9g, 2.0 mol) was added dropwise to the reaction solution, which was naturally raised to room temperature after dropping, and the reaction was continued for 18h (overnight), and the reaction was stopped when mono-substituted impurities were monitored to be almost consumed by TLC. The reaction solution was cooled down and quenched with methanol, and a small amount of silica gel and diatomaceous earth was spread in a Brinell's funnel to filter the reaction solution, which was concentrated to obtain 113.5 g of 111,6-dicyano-2,5-dioxahexane in 81% yield.
Step 2, Synthesis of 1,8-diamino-3,6-dioxaoctane
1,6-dicyano-2,5-dioxohexane (100 g, 0.71 mol), 1 L of methanol, and Pd/C (25 g, 25%) were placed in a 2 L three-neck flask. Then hydrogen was passed into the reaction solution until the end of the reaction, and then the hydrogen was stopped. After filtration and concentration, crude 1,8-diamino-3,6-dioxaoctane was obtained, and 79.3 g of pure 1,8-diamino-3,6-dioxaoctane was obtained after distillation under reduced pressure in 75% yield.
1,8-Diamino-3,6-dioxaoctane Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ucheml Medicine Co., Ltd. | 0519-86058959 13775231161 | sales@uchemi.cn | China | 301 | 50 |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Jiangsu Huaweisite Pharmaceutical Technology Co., Ltd. | 0519-88721112 | supporting@harvechem.com | China | 84 | 58 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1998 | 55 |
| Xiamen Sinopeg Biotech Co., Ltd. | 400-9189898 17359873007 | sales@sinopeg.com | China | 1003 | 58 |
| Shanghai Bosi Electronic Materials Co., Ltd. | 13916923354 13501880914 | 13585846964@139.com | China | 24 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 1,8-Diamino-3,6-dioxaoctane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-24 | 2,2'-(ethane-1,2-diylbis(oxy))bis(ethan-1-amine)
929-59-9
|
1g | 98% | 1g/bottle, 10g/bottle, 100g/bottle | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-07-15 | Bis-NH2-PEG2
929-59-9
|
10g | TargetMol Chemicals Inc. | ||||
 |
2026-05-28 | 1, 8-Diamino-3, 6-Dioxaoctane
929-59-9
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2,2'-(ethane-1,2-diylbis(oxy))bis(ethan-1-amine)
929-59-9
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Bis-NH2-PEG2
929-59-9
- $0.00
- TargetMol Chemicals Inc.
-
- 1, 8-Diamino-3, 6-Dioxaoctane
929-59-9
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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