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N-Methyl-4-piperidinecarboxylic acid methyl ester

N-Methyl-4-piperidinecarboxylic acid methyl ester structure

CAS No.: 1690-75-1

Chemical Name:: N-Methyl-4-piperidinecarboxylic acid methyl ester

Synonyms: METHYL 1-METHYLPIPERIDINE-4-CARBOXYLATE;Methyl N-methylisonipecotinate;1-methylisonipecotic acid methyl ester;Methyl N-methyl-4-piperidinecarboxylate;Methyl 1-Methyl-4-piperidinecarboxylate;Methyl N-methylPiperidine-4-carboxylate1;N-methyl piperidine-4-carboxylate, methyl ester;Methyl-4-piperidine carboxylic acid methyl ester;N-METHYLPIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER;1-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

CBNumber:: CB7428133

Molecular Formula:: C8H15NO2

Molecular Weight:: 157.21

MDL Number:: MFCD06658483

MOL File:: 1690-75-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:56

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N-Methyl-4-piperidinecarboxylic acid methyl ester Properties

Boiling point	202°C(lit.)
Density	1.0806 (rough estimate)
refractive index	1.4520 to 1.4560
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
pka	8.43±0.10(Predicted)
color	Colorless to Light yellow
InChI	InChI=1S/C8H15NO2/c1-9-5-3-7(4-6-9)8(10)11-2/h7H,3-6H2,1-2H3
InChIKey	KYAOKPRJTMFBTQ-UHFFFAOYSA-N
SMILES	N1(C)CCC(C(OC)=O)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

HS Code

2933399990

NFPA 704

	2
2		0

N-Methyl-4-piperidinecarboxylic acid methyl ester price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2961	Methyl 1-Methyl-4-piperidinecarboxylate >98.0%(GC)(T)	1690-75-1	1g	$21	2026-04-30	Buy
TCI Chemical	M2961	Methyl 1-Methyl-4-piperidinecarboxylate >98.0%(GC)(T)	1690-75-1	5g	$59	2026-04-30	Buy
Chem-Impex	17425	N-Methyl-4-piperidinecarboxylic acid methyl ester ≥98%(HPLC)	1690-75-1	1G	$18.53	2026-05-19	Buy
Chem-Impex	17425	N-Methyl-4-piperidinecarboxylic acid methyl ester ≥98%(HPLC)	1690-75-1	5G	$53.48	2026-05-19	Buy
Chem-Impex	17425	N-Methyl-4-piperidinecarboxylic acid methyl ester ≥98%(HPLC)	1690-75-1	25G	$149.72	2026-05-19	Buy

Product number	Packaging	Price	Buy
M2961	1g	$21	Buy
M2961	5g	$59	Buy
17425	1G	$18.53	Buy
17425	5G	$53.48	Buy
17425	25G	$149.72	Buy

N-Methyl-4-piperidinecarboxylic acid methyl ester Chemical Properties, Uses, Production

Synthesis

67-56-1

2971-79-1

N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER

1690-75-1

To a stirred solution of methyl 4-piperidinecarboxylate (7.00 mmol) in methanol (25 mL) was sequentially added formic acid (5.52 g, 12.00 mmol) and 40% aqueous formaldehyde (2.67 g, 35.00 mmol). The reaction mixture was heated to reflux. after 3 h, the reaction mixture was cooled and concentrated under reduced pressure. The residue was dissolved in water, alkalized with sodium bicarbonate solution and extracted with dichloromethane (3 x 30 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give methyl N-methyl-4-piperidinecarboxylate in brown liquid form (yield: 910 mg). NMR hydrogen spectrum (270 MHz, CDCl3, TMS as internal standard) δ: 1.69-2.03 (6H, m), 2.23-2.32 (4H, m), 2.78-2.83 (2H, m), 3.68 (3H, s). Mass spectrum (APCI) m/z: 158 ([M+H]+, 100%), 126 (C7H12ON, 33%).

References

[1] Patent: WO2004/58259, 2004, A1. Location in patent: Page/Page column 26-27

N-Methyl-4-piperidinecarboxylic acid methyl ester synthesis

Synthesis of N-Methyl-4-piperidinecarboxylic acid methyl ester from Methanol and Methyl isonipecotate

N-Methyl-4-piperidinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

Pyridinium, 4-(methoxycarbonyl)-1-methyl-, iodide (1:1) 1-Methylpiperidine-4-carboxylic acid hydrochloride Methyl isonicotinate Methanol Isonicotinic acid

Formic acid Methyl isonipecotate Isonipecotic acid Formaldehyde

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Preparation Products

Methyl1-methyl-1,2,3,6-tetrahydropyridine-4-carboxylate

N-Methyl-4-piperidinecarboxylic acid methyl ester Suppliers

Global Suppliers ( 156)

Supplier	Tel	Email	Country	ProdList	Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64

Supplier	Advantage
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64

View Latest Price from N-Methyl-4-piperidinecarboxylic acid methyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER 1690-75-1	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2022-02-25	N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER 1690-75-1		1KG	98%	1000	Jinan Ande Pharmaceutical Co.,Ltd.
2021-11-15	Methyl N-methyl piperidine-4-carboxylate 1690-75-1		1KG	98%	500ton/Month	Qiuxian Baitai New Material Co., LTD

N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
1690-75-1
$1.10
99.00%
Dideu Industries Group Limited

N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
1690-75-1
98%
Jinan Ande Pharmaceutical Co.,Ltd.

Methyl N-methyl piperidine-4-carboxylate
1690-75-1
98%
Qiuxian Baitai New Material Co., LTD

N-Methyl-4-piperidinecarboxylic acid methyl ester Spectrum

N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER(1690-75-1)¹HNMR

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N-METHYLPIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER 1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID METHYL ESTER 1-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER Methyl N-methyl-4-piperidinecarboxylate 1-methylisonipecotic acid methyl ester Methyl N-methylPiperidine-4-carboxylate1 Methyl-4-piperidine carboxylic acid methyl ester Methyl 1-Methyl-4-piperidinecarboxylate Piperidine derivative CAS NO.1690-75-1 Methyl N-methyl piperidine-4-carboxylate Piperidine derivative Methyl N-methyl piperidine-4-carboxylate Methyl N-methylisonipecotinate 4-Piperidinecarboxylic acid, 1-methyl-, methyl ester N-methyl piperidine-4-carboxylate, methyl ester METHYL 1-METHYLPIPERIDINE-4-CARBOXYLATE N-Methyl-4-piperidinecarboxylic acid methyl ester 1690-75-1 Pyridine series