Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>2,4-Dichloro-5-aminopyrimidine

2,4-Dichloro-5-aminopyrimidine

2,4-Dichloro-5-aminopyrimidine Structure
2,4-Dichloro-5-aminopyrimidine structure
CAS No.
5177-27-5
Chemical Name:
2,4-Dichloro-5-aminopyrimidine
Synonyms
5-Amino-2,4-dichL;2,4-dichlorpyrimidin-5-amin;4-Dichloro-5-aminopyrimidine;2,4-Dichloro-5-pyrimidinamine;2,4-DICHLOROPYRIMIDIN-5-AMINE;5-AMINO-2,4-DICHLOROPYRIMIDINE;2,4-DICHLORO-5-AMINOPYRIMIDINE;2,4-Dichloropyrimidine-5-amine;5-Pyrimidinamine, 2,4-dichloro-;2,4-DICHLORO-PYRIMIDIN-5-YLAMINE
CBNumber:
CB7442834
Molecular Formula:
C4H3Cl2N3
Molecular Weight:
163.99
MDL Number:
MFCD05662684
MOL File:
5177-27-5.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
5-Amino-2,4-dichloropyrimidine 97% 731919 1g $31.3
5-Amino-2,4-dichloropyrimidine A604720 1g $45
5-Amino-2,4-dichloropyrimidine A604720 10g $160
5-Amino-2,4-dichloropyrimidine 95+% 073493 25g $178
2,4-Dichloropyrimidin-5-amine B868 5g $109
More product size
Request For Quotation

2,4-Dichloro-5-aminopyrimidine Properties

Melting point 108-112?C
Boiling point 290.7±20.0 °C(Predicted)
Density 1.606±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO, Methanol
form Solid
pka -1.55±0.29(Predicted)
color Brown
InChI InChI=1S/C4H3Cl2N3/c5-3-2(7)1-8-4(6)9-3/h1H,7H2
InChIKey RINHVELYMZLXIW-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(N)C(Cl)=N1
CAS DataBase Reference 5177-27-5(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H317-H318
Precautionary statements  P280-P301+P310+P330-P302+P352-P305+P351+P338+P310
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39-24/25
RIDADR  2811
WGK Germany  3
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  29335990
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
0
2 0

2,4-Dichloro-5-aminopyrimidine price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 731919 5-Amino-2,4-dichloropyrimidine 97% 5177-27-5 1g $31.3 2023-06-20 Buy
TRC A604720 5-Amino-2,4-dichloropyrimidine 5177-27-5 1g $45 2021-12-16 Buy
TRC A604720 5-Amino-2,4-dichloropyrimidine 5177-27-5 10g $160 2021-12-16 Buy
Matrix Scientific 073493 5-Amino-2,4-dichloropyrimidine 95+% 5177-27-5 25g $178 2021-12-16 Buy
AK Scientific B868 2,4-Dichloropyrimidin-5-amine 5177-27-5 5g $109 2021-12-16 Buy
Product number Packaging Price Buy
731919 1g $31.3 Buy
A604720 1g $45 Buy
A604720 10g $160 Buy
073493 25g $178 Buy
B868 5g $109 Buy

2,4-Dichloro-5-aminopyrimidine Chemical Properties,Uses,Production

Chemical Properties

Brown Solid

Uses

A pyrimidinamine derivative as Plk1 inhibitors

Synthesis

2,4-Dichloro-5-nitropyrimidine

49845-33-2

2,4-Dichloro-5-aminopyrimidine

5177-27-5

General procedure for the synthesis of 5-amino-2,4-dichloropyrimidine from 2,4-dichloro-5-nitropyrimidine: 2,4-dichloro-5-nitropyrimidine (1.0 eq.) and iron powder (6.0 eq.) were formulated in acetic acid to form a non-homogeneous reaction system at a concentration of 0.4 M, and the reaction was carried out for 14 hours at room temperature with vigorous stirring. Upon completion of the reaction, the reaction mixture was thermally filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was washed with methanol (MeOH) and the volatile solvent was subsequently evaporated under reduced pressure. The resulting residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated sodium carbonate (Na2CO3) solution and saturated sodium chloride (NaCl) solution to remove acidic impurities and salts. The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 5-amino-2,4-dichloropyrimidine in 80% yield. The product was analyzed by liquid chromatography-mass spectrometry (LCMS), showing a molecular ion peak (MH+) of 157.0 and a retention time (Rt) of 1.85 min.

References

[1] Patent: US2011/195980, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: WO2011/106168, 2011, A1. Location in patent: Page/Page column 83; 84; 101; 102
[3] Journal of the Chemical Society, 1951, p. 1565,1568
[4] Journal of the Chemical Society, 1953, p. 1646
[5] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 352,354

2,4-Dichloro-5-aminopyrimidine Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-nitropyrimidine Ethyl acetate Sodium carbonate

Preparation Products

2,4-Dichloro-5-aminopyrimidine Suppliers

Global( 236)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29734 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 4000 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Accela ChemBio Inc. 		58
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
Antai Fine Chemical Technology Co.,Limited 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 2,4-Dichloro-5-aminopyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dichloro-5-aminopyrimidine pictures 2025-04-04 2,4-Dichloro-5-aminopyrimidine
5177-27-5
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2,4-Dichloro-5-aminopyrimidine pictures 2021-07-13 2,4-Dichloro-5-aminopyrimidine
5177-27-5
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2,4-Dichloro-5-aminopyrimidine pictures 2021-07-10 2,4-Dichloro-5-aminopyrimidine
5177-27-5
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

2,4-Dichloro-5-aminopyrimidine Spectrum

2,4-Dichloro-5-aminopyrimidine(5177-27-5)1HNMR

5177-27-5(2,4-Dichloro-5-aminopyrimidine)Related Search:

2',4'-Dichloroacetophenone 1,2-Dichloro-4-(chloromethyl)benzene Dichloroethane Glycine 6-Aminocaproic acid
3-Aminophenol ALTRENOGEST EC 2.6.1.2 2,4-Dichloropyrimidine Acetaminophen
5-Amino-2-chloropyrimidine Tris(hydroxymethyl)aminomethane 2,4-Dichloro-6-methyl-5-nitropyrimidine 2,4-DICHLORO-5-AMINO-6-METHYLPYRIMIDINE 2,4,6-TRICHLORO-5-NITROPYRIMIDINE
2,6-Dichloro-4-aminopyrimidine 2,4-Dichloro-5-nitropyrimidine 2,4-Dichloro-5-(1H-pyrazol-1-yl)pyrimidine

1of4

2,4-DICHLORO-PYRIMIDIN-5-YLAMINE 2,4-DICHLORO-5-AMINOPYRIMIDINE 5-AMINO-2,4-DICHLOROPYRIMIDINE 2,4-DICHLOROPYRIMIDIN-5-AMINE 5-Amino-2,4-dichloropyrimidine ,98% 2,4-Dichloro-5-pyrimidinamine 5-AMino-2,4-dichloropyriMidine 97% 2,4-di chloro-5-aMinoMpyriMidine 5-Pyrimidinamine, 2,4-dichloro- 5-Amino-2,4-dichL 5-Amino-2,4-dichloropyrimidine,97% 2,4-Dichloropyrimidine-5-amine 2,4-dichlorpyrimidin-5-amin 4-Dichloro-5-aminopyrimidine 2,4-Dichloropyrimidin-5-amine 97% 5177-27-5 Heterocycle-Pyrimidine series Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals pharmacetical Amines