2,4-Dichloro-5-aminopyrimidine
- CAS No.
- 5177-27-5
- Chemical Name:
- 2,4-Dichloro-5-aminopyrimidine
- Synonyms
- 2,4-DICHLOROPYRIMIDIN-5-AMINE;5-Amino-2,4-dichL;2,4-dichlorpyrimidin-5-amin;4-Dichloro-5-aminopyrimidine;2,4-Dichloro-5-pyrimidinamine;2,4-Dichloropyrimidine-5-amine;5-AMINO-2,4-DICHLOROPYRIMIDINE;2,4-DICHLORO-5-AMINOPYRIMIDINE;5-Pyrimidinamine, 2,4-dichloro-;2,4-DICHLORO-PYRIMIDIN-5-YLAMINE
- CBNumber:
- CB7442834
- Molecular Formula:
- C4H3Cl2N3
- Molecular Weight:
- 163.99
- MDL Number:
- MFCD05662684
- MOL File:
- 5177-27-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 108-112C |
|---|---|
| Boiling point | 290.7±20.0 °C(Predicted) |
| Density | 1.606±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | -1.55±0.29(Predicted) |
| color | Brown |
| InChI | InChI=1S/C4H3Cl2N3/c5-3-2(7)1-8-4(6)9-3/h1H,7H2 |
| InChIKey | RINHVELYMZLXIW-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(N)C(Cl)=N1 |
| CAS DataBase Reference | 5177-27-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H317-H318 | |||||||||
| Precautionary statements | P280-P301+P310+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39-24/25 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Dam. 1 Skin Sens. 1 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,4-Dichloro-5-aminopyrimidine price More Price(62)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 731919 | 5-Amino-2,4-dichloropyrimidine 97% | 5177-27-5 | 1g | $31.3 | 2023-06-20 | Buy |
| Usbiological | 233850 | 5-Amino-2,4-dichloropyrimidine 98+% ≥98%(Assay) | 5177-27-5 | 1g | $170 | 2026-06-03 | Buy |
| Usbiological | 233850 | 5-Amino-2,4-dichloropyrimidine 98+% ≥98%(Assay) | 5177-27-5 | 5g | $226 | 2026-06-03 | Buy |
| Usbiological | 233850 | 5-Amino-2,4-dichloropyrimidine 98+% ≥98%(Assay) | 5177-27-5 | 25g | $496 | 2026-06-03 | Buy |
| Usbiological | 233850 | 5-Amino-2,4-dichloropyrimidine 98+% ≥98%(Assay) | 5177-27-5 | 100g | $1409 | 2026-06-03 | Buy |
2,4-Dichloro-5-aminopyrimidine Chemical Properties, Uses, Production
Chemical Properties
Brown Solid
Uses
A pyrimidinamine derivative as Plk1 inhibitors
Synthesis
49845-33-2
5177-27-5
General procedure for the synthesis of 5-amino-2,4-dichloropyrimidine from 2,4-dichloro-5-nitropyrimidine: 2,4-dichloro-5-nitropyrimidine (1.0 eq.) and iron powder (6.0 eq.) were formulated in acetic acid to form a non-homogeneous reaction system at a concentration of 0.4 M, and the reaction was carried out for 14 hours at room temperature with vigorous stirring. Upon completion of the reaction, the reaction mixture was thermally filtered through a diatomaceous earth pad to remove insoluble impurities. The filtrate was washed with methanol (MeOH) and the volatile solvent was subsequently evaporated under reduced pressure. The resulting residue was dissolved in ethyl acetate (EtOAc) and washed sequentially with saturated sodium carbonate (Na2CO3) solution and saturated sodium chloride (NaCl) solution to remove acidic impurities and salts. The organic phase was dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 5-amino-2,4-dichloropyrimidine in 80% yield. The product was analyzed by liquid chromatography-mass spectrometry (LCMS), showing a molecular ion peak (MH+) of 157.0 and a retention time (Rt) of 1.85 min.
References
[1] Patent: US2011/195980, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: WO2011/106168, 2011, A1. Location in patent: Page/Page column 83; 84; 101; 102
[3] Journal of the Chemical Society, 1951, p. 1565,1568
[4] Journal of the Chemical Society, 1953, p. 1646
[5] Chemical and Pharmaceutical Bulletin, 1958, vol. 6, p. 352,354
2,4-Dichloro-5-aminopyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hunan Caiya Biological Technology Co., Ltd | 15580017485 | 2036676503@qq.com | China | 91 | 58 |
| Shandong Meiao Huawei Technology Co., LTD | 0531-88682301 18595278766 | yuhongmeng@mayowell.com | China | 88 | 58 |
| Shijiazhuang Qiyue Chemical Co. LTD | 15369111890 | sjzqiyuekeji@163.com | China | 342 | 58 |
| SHANGHAI SAGACHEM CO., LTD. | 021-68404722 13816115801 | david_si@shjlchem.com | China | 228 | 58 |
| Changzhou Standard Chemicals Ltd. | 0519-85607885 13776800733 | email@standardschem.com | China | 118 | 62 |
| Hangzhou Copiore Chemical Co., Ltd. | 17300981287 13757145729 | sales@copiore.com | China | 291 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 2,4-Dichloro-5-aminopyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2,4-Dichloro-5-aminopyrimidine
5177-27-5
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-13 | 2,4-Dichloro-5-aminopyrimidine
5177-27-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 2,4-Dichloro-5-aminopyrimidine
5177-27-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2,4-Dichloro-5-aminopyrimidine
5177-27-5
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2,4-Dichloro-5-aminopyrimidine
5177-27-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2,4-Dichloro-5-aminopyrimidine
5177-27-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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