5-Amino-2-chloropyrimidine
- CAS No.
- 56621-90-0
- Chemical Name:
- 5-Amino-2-chloropyrimidine
- Synonyms
- 2-CHLOROPYRIMIDIN-5-AMINE;2-Chloro-5-pyrimidinamine;5-amine-2-Chloropyrimidine;5-AMINO-2-CHLOROPYRIMIDINE;5-PYRIMIDINAMINE, 2-CHLORO-;2-Chloro-pyrimidin-5-ylamine;5-AMINO-2-CHLOROPYRIMIDINE,98%;5-AMino-2-chloropyriMidine 97%;5-Amino-2-chloropyrimidine ,97%;5-Pyrimidinamine, 2-chloro- (9CI)
- CBNumber:
- CB4461216
- Molecular Formula:
- C4H4ClN3
- Molecular Weight:
- 129.55
- MDL Number:
- MFCD06412560
- MOL File:
- 56621-90-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 198-199℃ |
|---|---|
| Boiling point | 338.8±15.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | -0.08±0.10(Predicted) |
| form | Crystalline Powder or Solid |
| color | Yellow to brown |
| InChI | InChI=1S/C4H4ClN3/c5-4-7-1-3(6)2-8-4/h1-2H,6H2 |
| InChIKey | DZBKIOJXVOECRA-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(N)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | Xn |
| Risk Statements | 22-36-36/37/38 |
| Safety Statements | 26-36/37/39-22 |
| HS Code | 29339900 |
5-Amino-2-chloropyrimidine price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR30541 | 5-Amino-2-chloropyrimidine 98% | 56621-90-0 | 1g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR30541 | 5-Amino-2-chloropyrimidine 98% | 56621-90-0 | 5g | $98 | 2026-06-04 | Buy |
| Activate Scientific | AS1160 | 5-Amino-2-chloropyrimidine 97% | 56621-90-0 | 1g | $45 | 2026-06-04 | Buy |
| Activate Scientific | AS1160 | 5-Amino-2-chloropyrimidine 97% | 56621-90-0 | 5g | $103 | 2026-06-04 | Buy |
| Activate Scientific | AS1160 | 5-Amino-2-chloropyrimidine 97% | 56621-90-0 | 25g | $409 | 2026-06-04 | Buy |
5-Amino-2-chloropyrimidine Chemical Properties, Uses, Production
Chemical Properties
Light yellow solid
Uses
5-Amino-2-chloropyrimidine is an aminopyrimidine derivative, a fibroblast growth factor receptor 4 inhibitor with anticancer activity.
Hazard
5-Amino-2-chloropyrimidine has acute oral toxicity, it causes skin corrosion/irritation and severe eye damage/eye irritation.
Synthesis
10320-42-0
56621-90-0
Example 7 Synthesis of 5-amino-2-chloropyrimidine (Compound 40): according to the reaction scheme, 140 g (0.88 mol) of 2-chloro-5-nitropyrimidine (39) was dissolved in 700 mL of ethanol (EtOH) with the addition of 1400 mL of acetic acid, 700 mL of water and 197 g of iron powder (70 μm sieve, <212 μm). The reaction mixture was heated at 70 °C overnight and subsequently cooled to room temperature. After completion of the reaction, filtration was performed. EtOH was removed from the filtrate under vacuum and the pH was adjusted to 8 with 12N NaOH, followed by continuous liquid-liquid extraction with ethyl acetate (EtOAc) overnight to extract the product. The resulting filter cake was washed with EtOAc and the combined EtOAc layers were washed sequentially with water and brine, dried with magnesium sulfate and filtered. The solvent was removed under vacuum and the product was recrystallized with EtOH to give 97.2 g (85% yield) of the final light brown solid product 39.1H NMR (DMSO-d6) δ 8.94 (s, 2H), 5.77 (brs, 2H).
References
[1] Tetrahedron, 2014, vol. 70, # 35, p. 5730 - 5738
[2] Patent: WO2017/176812, 2017, A1. Location in patent: Paragraph 0267
[3] Patent: US2014/235858, 2014, A1. Location in patent: Paragraph 0093
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 22, p. 8796 - 8805
[5] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 56
5-Amino-2-chloropyrimidine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hunan Caiya Biological Technology Co., Ltd | 15580017485 | 2036676503@qq.com | China | 91 | 58 |
| Shandong Zhonghan Pharmaceutical Co.,Ltd. | 15315818580 18562151612 | 2289008634@qq.com | China | 296 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 5-Amino-2-chloropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 5-Amino-2-chloropyrimidine
56621-90-0
|
$1.10-9.90 | 1KG | 99%min | 100KG | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2020-05-15 | 2-chloropyrimidin-5-amine
56621-90-0
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 5-Amino-2-chloropyrimidine
56621-90-0
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 5-Amino-2-chloropyrimidine
56621-90-0
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-chloropyrimidin-5-amine
56621-90-0
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-Amino-2-chloropyrimidine
56621-90-0
- $1.00
- 98%
- Career Henan Chemical Co
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