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N-Acetyl carnosine

N-Acetyl carnosine Structure
N-Acetyl carnosine structure
CAS No.
56353-15-2
Chemical Name:
N-Acetyl carnosine
Synonyms
N-ACETYL-L-CARNOSINE;Acetyl Carnosine;N-Acetyl camosine;N-Aceyl-L-Carnosine;Can-C;Acetyl carinine;Ac-βAla-L-His-OH;AC-SS-ALA-HIS-OH;n-acetyl carnosine;Carnosine Impurity 4
CBNumber:
CB7476624
Molecular Formula:
C11H16N4O4
Molecular Weight:
268.27
MDL Number:
MFCD04039376
MOL File:
56353-15-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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N-Acetyl carnosine Properties

Melting point 209-210°C
Boiling point 775.9±60.0 °C(Predicted)
Density 1.343±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
pka 3.08±0.10(Predicted)
color White to Off-White
Cosmetics Ingredients Functions SKIN PROTECTING
InChI InChI=1/C11H16N4O4/c1-7(16)13-3-2-10(17)15-9(11(18)19)4-8-5-12-6-14-8/h5-6,9H,2-4H2,1H3,(H,12,14)(H,13,16)(H,15,17)(H,18,19)/t9-/s3
InChIKey BKAYIFDRRZZKNF-DJEYLCQNNA-N
SMILES [C@H](C(=O)O)(NC(=O)CCNC(=O)C)CC1N=CNC=1 |&1:0,r|
FDA UNII 0TPN86OQIF

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

N-Acetyl carnosine price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18817 N-acetyl-L-Carnosine ≥95% 56353-15-2 100mg $36 2026-04-30 Buy
Cayman Chemical 18817 N-acetyl-L-Carnosine ≥95% 56353-15-2 1g $70 2026-04-30 Buy
Cayman Chemical 18817 N-acetyl-L-Carnosine ≥95% 56353-15-2 5g $186 2026-04-30 Buy
Usbiological A0202-40 N-Acetyl-L-Carnosine (NAC) ≥95% 56353-15-2 1g $347 2026-06-03 Buy
Usbiological A0202-40 N-Acetyl-L-Carnosine (NAC) ≥95% 56353-15-2 5g $588 2026-06-03 Buy
Product number Packaging Price Buy
18817 100mg $36 Buy
18817 1g $70 Buy
18817 5g $186 Buy
A0202-40 1g $347 Buy
A0202-40 5g $588 Buy

N-Acetyl carnosine Chemical Properties, Uses, Production

Description

N-acetyl-L-Carnosine is a dipeptide and acetylated form of L-carnosine that has been found in heart and skeletal muscle and has antioxidant and anticataract activities. It reduces iron- and ascorbate-induced malondialdehyde (MDA) accumulation in liposomes when used at concentrations of 10 and 20 mM. Topical administration of N-acetyl-L-carnosine (1% v/v) reduces cortical opacities in a canine model of age-related cataracts.

Chemical Properties

White Crystalline Solid

Uses

N-acetyl-L-Carnosine is used in the treatment of cataracts and in the treatment of UV-induced immunosuppression

Definition

ChEBI: A dipeptide that is the N-acetyl derivative of carnosine.

Synthesis

AC-BETA-ALA-OH

3025-95-4

L-Histidine

71-00-1

N-Acetyl carnosine

56353-15-2

In a 500 mL three-necked flask, 300 mL of anhydrous ethanol was added and 80 g (0.611 mol) of N-acetyl-β-alanine and 86.1 g (0.555 mol) of L-histidine were sequentially added followed by 98 g (0.582 mol) of N,N'-dimethylcarbodiimide (DMC). The reaction mixture was heated to 40°C and the reaction was kept stirring for 3 hours. Upon completion of the reaction, the reaction solution was cooled to 5°C, a solid was precipitated and the solid product was collected by filtration. The filter cake was washed with 150 mL of anhydrous ethanol and dried under vacuum to give 145 g of (S)-2-(3-acetamidopropionamide)-3-(1H-imidazol-4-yl)propanoic acid (IV) in 97.9% yield and >98.8% HPLC purity.

in vivo

Right eyes of the rabbits (male grey chinchilla rabbits aged 3-4 months weighing 2-3 k) are instilled with 80 μL of formulation A containing 1 % N-Acetylcarnosine. The N-Acetylcarnosine prodrug eye drops optimize the clinical effects for the treatment of ophthalmic disorders (such as prevention and reversal of cataracts in human and animal eyes)[1].

IC 50

Human Endogenous Metabolite

References

[1] Patent: CN105461632, 2016, A. Location in patent: Paragraph 0046

N-Acetyl carnosine synthesis

3025-95-4
71-00-1
56353-15-2
Synthesis of N-Acetyl carnosine from Ac-beta-Ala-OH and L-Histidine

N-Acetyl carnosine Preparation Products And Raw materials

Raw materials

Ac-beta-Ala-OH 2-Chloro-1,3-dimethylimidazolidinium chloride L-Histidine Ethanol

Preparation Products

N-Acetyl carnosine Suppliers

Global Suppliers ( 350)
Supplier Tel Email Country ProdList Advantage
Shanghai Joy Biotech Ltd 135-88459597 13588459597 miley@joybiotech.com China 35 58
Hubei hong peptide biotechnology co., LTD 027-87781035-802 18071013508; caobo@huntide.com China 9 58
Sichuan Jisheng Biopharmaceutical Co.,Ltd. +86-0833-2598983 +86-18086877136 Nyx-peptide@jsjpharm.cn China 287 58
Nanjing Leon Biological Technology Co., Ltd. 025-84523390 -127; 17705183659 sales@njleonbiotech.com China 5501 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Shanghai Joy Biotech Ltd 58
Hubei hong peptide biotechnology co., LTD 58
Sichuan Jisheng Biopharmaceutical Co.,Ltd. 58
Nanjing Leon Biological Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Wuhan Chemwish Technology Co., Ltd 56
GL Biochem (Shanghai) Ltd 64
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Adamas Reagent, Ltd. 59

Related articles

View Latest Price from N-Acetyl carnosine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-Acetyl carnosine pictures 2026-09-19 N-Acetyl carnosine
56353-15-2
 0.99 RongNa Biotechnology Co.,Ltd
N-Acetyl carnosine pictures 2026-09-18 N-Acetyl carnosine
56353-15-2
 1g 98.0% 1kg/month WUHAN FORTUNA CHEMICAL CO., LTD
N-Acetyl carnosine pictures 2026-09-17 N-Acetyl carnosine
56353-15-2
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd

N-Acetyl carnosine Spectrum

N-Acetyl carnosine(56353-15-2)1HNMR

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(S)-2-(3-ACETYLAMINO-PROPIONYLAMINO)-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID n-acetyl carnosine N-A-ACETYL-N-B-ALANYL-L-HISTIDINE N-Aceyl-L-Carnosine NAC, N-a-Acetyl-N-b-alanyl-L-histidine N-(N-acetyl-beta-alanyl)-L-histidine Acetyl-beta-alanyl-histidine AC-SS-ALA-HIS-OH Ac-βAla-L-His-OH Nα-(N-Acetyl-β-alanyl)-L-histidine L-Histidine, N-acetyl-.beta.-alanyl- Ac-Beta-Ala-His-OH(L-Carnosine) NAC, N-α-Acetyl-N-β-alanyl-L-histidine (S)-2-(3-AcetaMidopropanaMido)-3-(1H-iMidazol-4-yl)propanoic acid NAC, N-a-Acetyl-N--alanyl-L-histidine L-Histidine, N-acetyl-b-alanyl- N-Acetyl-L-carnosine, >=98.5% N-Acetyl carnosine / Dipeptide Can-C Carnosine Impurity 4 L-Histidine, N-acetyl-β-alanyl- Acetyl carinine N-Acetyl carnosine USP/EP/BP Carnosine Impurity 2 N-Acetyl-L-CarnosineQ: What is N-Acetyl-L-Carnosine Q: What is the CAS Number of N-Acetyl-L-Carnosine Q: What is the storage condition of N-Acetyl-L-Carnosine Q: What are the applications of N-Acetyl-L-Carnosine (2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid N-AcetylCarnosine: (S)-2-(3-Acetamidopropanamido)-3-(1H-imidazol-4-yl)propanoicacid Acetyl Carnosine N-Acetyl camosine N-ACETYL-L-CARNOSINE 56353-15-2 56353-23-0 Amino Acids & Derivatives Heterocycles Intermediates & Fine Chemicals Pharmaceuticals PROTECTED AMINO ACID & PEPTIDES