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3,4,5-Trimethoxybenzoyl chloride

3,4,5-Trimethoxybenzoyl chloride Structure
3,4,5-Trimethoxybenzoyl chloride structure
CAS No.
4521-61-3
Chemical Name:
3,4,5-Trimethoxybenzoyl chloride
Synonyms
SKL1322;AKOS BBS-00003922;Troxipide Impurity 2;Trimethylgalloyl chloride;Tri-O-methylgalloyl chloride;3,4,5-trimethoxy-benzoylchlorid;3,4,5-TRIMETHOXYBENZOYL CHLORIDE;Benzoyl chloride, 3,4,5-trimethoxy-;3,4,5-Trimethoxybenzoic acid chloride;sulfuric acid [(8R,9S,13S,14S,16R,17R)-3,16-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] ester
CBNumber:
CB7479180
Molecular Formula:
C10H11ClO4
Molecular Weight:
230.64
MDL Number:
MFCD00000675
MOL File:
4521-61-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:24:16
Product description Number Pack Size Price
3,4,5-Trimethoxybenzoyl chloride 98% T69809 25g $217
3,4,5-Trimethoxybenzoyl Chloride >97.0%(T) T1842 25g $89
3,4,5-Trimethoxybenzoyl Chloride TRC-T796225-5G 5g $91
3,4,5-Trimethoxybenzoyl Chloride TRC-T796225-25G 25g $135
3,4,5-Trimethoxybenzoyl Chloride TRC-T796225-100G 100g $385
More product size
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3,4,5-Trimethoxybenzoyl chloride Properties

Melting point 81-84 °C (lit.)
Boiling point 185 °C/18 mmHg (lit.)
Density 1,214 g/cm3
refractive index 1.4571 (estimate)
Flash point 185°C/18mm
storage temp. 2-8°C
solubility soluble in Toluene
form powder to crystal
color White to Orange to Green
Sensitive Moisture Sensitive
BRN 403117
InChI 1S/C10H11ClO4/c1-13-7-4-6(10(11)12)5-8(14-2)9(7)15-3/h4-5H,1-3H3
InChIKey BUHYMJLFRZAFBF-UHFFFAOYSA-N
SMILES COc1cc(cc(OC)c1OC)C(Cl)=O
LogP 2.400 (est)
CAS DataBase Reference 4521-61-3(CAS DataBase Reference)
NIST Chemistry Reference 3,4,5-Trimethoxybenzoyl chloride(4521-61-3)
EPA Substance Registry System Benzoyl chloride, 3,4,5-trimethoxy- (4521-61-3)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H335
Precautionary statements  P260-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  C
Risk Statements  14-34-37
Safety Statements  26-36/37/39-45
RIDADR  UN 3261 8/PG 2
WGK Germany  1
F  9-21
TSCA  TSCA listed
HazardClass  8
PackingGroup  II
HS Code  29189900
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Skin Corr. 1B
STOT SE 3
REACH Registrations Active
NFPA 704
0
3 0

3,4,5-Trimethoxybenzoyl chloride price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T69809 3,4,5-Trimethoxybenzoyl chloride 98% 4521-61-3 25g $217 2026-04-30 Buy
TCI Chemical T1842 3,4,5-Trimethoxybenzoyl Chloride >97.0%(T) 4521-61-3 25g $89 2026-04-30 Buy
TRC TRC-T796225-5G 3,4,5-Trimethoxybenzoyl Chloride 4521-61-3 5g $91 2026-06-03 Buy
TRC TRC-T796225-25G 3,4,5-Trimethoxybenzoyl Chloride 4521-61-3 25g $135 2026-06-03 Buy
TRC TRC-T796225-100G 3,4,5-Trimethoxybenzoyl Chloride 4521-61-3 100g $385 2026-06-03 Buy
Product number Packaging Price Buy
T69809 25g $217 Buy
T1842 25g $89 Buy
TRC-T796225-5G 5g $91 Buy
TRC-T796225-25G 25g $135 Buy
TRC-T796225-100G 100g $385 Buy

3,4,5-Trimethoxybenzoyl chloride Chemical Properties,Uses,Production

Uses

3,4,5-Trimethoxybenzoyl Chloride is used as a reagent in the synthesis of 2-methyl-8-(3,4,5-trimethoxybenzamido)-1,2,3,4-tetrahydroisoquinoline and its analogs which display great antihypertensive activity.

Synthesis

3,4,5-Trimethoxy benzoic acid

118-41-2

3,4,5-Trimethoxybenzoyl chloride

4521-61-3

The general procedure for the synthesis of 3,4,5-trimethoxybenzoyl chloride from 3,4,5-trimethoxybenzoic acid was as follows: thionyl chloride (13.7 mL, 189 mmol) was added dropwise to a solution of CHCl3 (30 mL) containing 3,4,5-trimethoxybenzoic acid (8.00 g, 37.7 mmol). After the dropwise addition, the reaction mixture was heated to reflux and maintained for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature. Subsequently, the solvent and excess thionyl chloride were removed by distillation under reduced pressure to afford 3,4,5-trimethoxybenzoyl chloride as a colorless oil in quantitative yield. The obtained product can be used in the subsequent reaction without further purification. The characteristic absorption peaks of the infrared spectrum (NaCl) were: νmax/cm-1 2970, 2944, 1750, 1590, 1457, 1415, 1130, 1128.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 22, p. 5864 - 5869
[2] Tetrahedron, 2011, vol. 67, # 25, p. 4601 - 4611
[3] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 6042 - 6054
[4] Letters in Drug Design and Discovery, 2018, vol. 15, # 12, p. 1319 - 1328
[5] Bulletin of the Chemical Society of Japan, 2012, vol. 85, # 2, p. 236 - 244

3,4,5-Trimethoxybenzoyl chloride Preparation Products And Raw materials

Raw materials

3,4,5-Trimethoxy benzoic acid Chloroform Thionyl chloride

Preparation Products

TROXIPIDE Capobenic acid 3,4,5-Trimethoxyaniline 3',4',5',5,6,7-HEXAMETHOXYFLAVONE Trimethobenzamide
3,4,5-TRIMETHOXYBENZAMIDE 1-(3,4,5-Trimethoxybenzoyl)piperidine (5-nitroindazol-1-yl)-(3,4,5-trimethoxyphenyl)methanone 3,4,5-trimethoxy-N-(2-nitrophenyl)benzamide

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3,4,5-Trimethoxybenzoyl chloride Suppliers

Global( 220)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 17389186172 1077@dideu.com China 3999 58
Hebei Yanxi Chemical Co., Ltd. 		+86-17531190177 faithe@yan-xi.com China 5838 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32998 60
Zhejiang ZETian Fine Chemicals Co. LTD 		18957127338 stella@zetchem.com China 2993 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
YANGZHOU SHUANGDING CHEM CO., LTD 		0514-83613866 18051432592 Alice@shuangdingchem.com CHINA 69 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
SIMAGCHEM CORP 		58
YANGZHOU SHUANGDING CHEM CO., LTD 		58

View Lastest Price from 3,4,5-Trimethoxybenzoyl chloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
345-Trimethoxybenzoyl chloride pictures 2026-08-07 345-Trimethoxybenzoyl chloride
4521-61-3
 $11.00-25.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
3,4,5-Trimethoxybenzoyl chloride pictures 2025-06-20 3,4,5-Trimethoxybenzoyl chloride
4521-61-3
 $15.00-20.00 1KG 99% 50MT/month Hebei Yanxi Chemical Co., Ltd.
3,4,5-Trimethoxybenzoyl chloride pictures 2021-01-27 3,4,5-Trimethoxybenzoyl chloride
4521-61-3
 300KG 98.0% 50tons/year YANGZHOU SHUANGDING CHEM CO., LTD

3,4,5-Trimethoxybenzoyl chloride Spectrum

3,4,5-Trimethoxybenzoyl chloride(4521-61-3)1HNMR3,4,5-Trimethoxybenzoyl chloride(4521-61-3)IR1

4521-61-3(3,4,5-Trimethoxybenzoyl chloride)Related Search:

Trimethyl phosphite Ammonium chloride 2-Fluorobenzoyl chloride Oxalyl chloride o-Toluoyl chloride
Calcium chloride p-Toluoyl chloride 2,4,6-Trimethylbenzoyl chloride Sodium chloride 4-tert-Butylbenzoyl chloride
Zinc chloride Choline chloride Benzoyl chloride Thionyl chloride (Trifluoromethoxy)benzene
4-Chlorobenzoyl chloride Potassium chloride 2-Nitrobenzoyl chloride

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sulfuric acid [(8R,9S,13S,14S,16R,17R)-3,16-dihydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] ester 3,4,5-trimethoxy-benzoylchlorid Benzoyl chloride, 3,4,5-trimethoxy- Trimethylgalloyl chloride Tri-O-methylgalloyl chloride 3,4,5-TRIMETHOXYBENZOYL CHLORIDE 3,4,5-Trimethoxybenzoic acid chloride AKOS BBS-00003922 Troxipide Impurity 2 SKL1322 4521-61-3 C10H11ClO4 C10H11O4Cl CH3O3C6H2COCl Building Blocks Carbonyl Compounds Organic Building Blocks Acid Halides ACID CHLORIDE Acid Halides Building Blocks Carbonyl Compounds Chemical Synthesis Organic Building Blocks Acid Halides Carbonyl Compounds Organic Building Blocks