CAERULOMYCIN A
- CAS No.
- 21802-37-9
- Chemical Name:
- CAERULOMYCIN A
- Synonyms
- CERULOMYCIN;CAERULOMYCIN;AERULOMYCIN A;Carulomycin A;CAERULOMYCIN A;Caerulomycin, Cerulomycin;CeruloMycin, CaeruloMycin A;Caerulomycin A, 10 mM in DMSO;Caerulomycin A (Synonyms: Cerulomycin;Fungal,Antibiotic,Caerulomycin A,inhibit,Inhibitor
- CBNumber:
- CB7484496
- Molecular Formula:
- C12H11N3O2
- Molecular Weight:
- 229.23
- MDL Number:
- MFCD03093715
- MOL File:
- 21802-37-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 173 °C |
|---|---|
| Boiling point | 420.0±45.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| pka | 9.89±0.50(Predicted) |
| form | solid |
| color | White |
| biological source | Streptomyces caeruleus |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C12H11N3O2/c1-17-10-6-9(8-14-16)15-12(7-10)11-4-2-3-5-13-11/h2-8,16H,1H3/b14-8+ |
| InChIKey | JCTRJRHLGOKMCF-RIYZIHGNSA-N |
| SMILES | COc1cc(\C=N\O)nc(c1)-c2ccccn2 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 |
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| NFPA 704 |
|
CAERULOMYCIN A price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6374 | Caerulomycin A from | 21802-37-9 | 1mg | $471 | 2026-04-30 | Buy |
| Cayman Chemical | 27625 | Caerulomycin A ≥98% | 21802-37-9 | 1mg | $323 | 2026-04-30 | Buy |
| Cayman Chemical | 27625 | Caerulomycin A ≥98% | 21802-37-9 | 5mg | $967 | 2026-04-30 | Buy |
| Biosynth | AC171308 | Caerulomycin A | 21802-37-9 | 1mg | $897.3 | 2026-06-04 | Buy |
| Biosynth | AC171308 | Caerulomycin A | 21802-37-9 | 5mg | $3813.55 | 2026-06-04 | Buy |
CAERULOMYCIN A Chemical Properties, Uses, Production
Description
Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretionin vitroandin vivo.1 Caerulomycin A induces expansion of regulatory T cells by via interfering with IFNγ -induced STAT1 signaling.2
Uses
Caerulomycin is a rare and unusual antibiotic containing a core 2, 2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces caeruleus isolated in Canada in 1959. Caerulomycin is active against fungi and some protozoans, and is weakly active against bacteria. While its discovery has stimulated some synthetic effort, little is known about the mode and spectrum of action of caerulomycin.
Uses
Caerulomycin A is a pyridine derived antiobiotic with a broad spectrum of bioactivity.
Definition
ChEBI: Caerulomycin A is a pyridine alkaloid that is 2,2'-bipyridine substituted by a methoxy group at position 4 and a (E)-(hydroxyimino)methyl group at position 6. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity. It has a role as an antineoplastic agent, a marine metabolite and a bacterial metabolite. It is an aldoxime, an aromatic ether, a member of bipyridines and a pyridine alkaloid. It derives from a hydride of a 2,2'-bipyridine.
References
[1] ARVIND K SINGLA. Caerulomycin A suppresses immunity by inhibiting T cell activity.[J]. ACS Applied Bio Materials, 2014: e107051. DOI:10.1371/journal.pone.0107051
[2] RAMA KRISHNA GURRAM. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs).[J]. The Journal of Biological Chemistry, 2014: 17515-17528. DOI:10.1074/jbc.m113.545871
CAERULOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
CAERULOMYCIN A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1363 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
View Latest Price from CAERULOMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-10 | CAERULOMYCIN A
21802-37-9
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-11 | Caerulomycin A
21802-37-9
|
$148.00-447.00 | 99.28% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-04-21 | Caerulomycin A
21802-37-9
|
$148.00-447.00 | 99.28% | 10g | TargetMol Chemicals Inc. |
-
- CAERULOMYCIN A
21802-37-9
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Caerulomycin A
21802-37-9
- $148.00-447.00
- 99.28%
- TargetMol Chemicals Inc.
-
- Caerulomycin A
21802-37-9
- $148.00-447.00
- 99.28%
- TargetMol Chemicals Inc.
