4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
- CAS No.
- 21642-98-8
- Chemical Name:
- 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
- Synonyms
- MPCN;AURORA KA-6226;N-DeMethylricinine;N-DeMethyl Ricinine;Gimeraux impurities2;-TropisetronC17H2N2O2;SS-TROPISETRONC17H2N2O2;3-Cyano-4-methoxy-2-pyridone;4-Methoxy-2-oxo-1,2-Dihydro-3-;3-Cyano-4-methoxy-2-pyridinone
- CBNumber:
- CB7490774
- Molecular Formula:
- C7H6N2O2
- Molecular Weight:
- 150.13
- MDL Number:
- MFCD00975442
- MOL File:
- 21642-98-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 293°C |
|---|---|
| Boiling point | 421.8±45.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in Dimethyl sulfoxide. |
| pka | 7.99±0.10(Predicted) |
| form | Crystalline Solid |
| color | Pale yellow |
| Sensitive | Hygroscopic |
| Stability | Hygroscopic |
| InChI | InChI=1S/C7H6N2O2/c1-11-6-2-3-9-7(10)5(6)4-8/h2-3H,1H3,(H,9,10) |
| InChIKey | MWGIDWPSRDMIQN-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC(OC)=C1C#N |
| CAS DataBase Reference | 21642-98-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,Xn,T | |||||||||
| Risk Statements | 20/21/22-36/37/38-22-25 | |||||||||
| Safety Statements | 26-36/37/39-45-24/25 | |||||||||
| RIDADR | 3439 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2925 | 3-Cyano-4-methoxy-2-pyridone >98.0%(HPLC)(T) | 21642-98-8 | 5g | $72 | 2026-04-30 | Buy |
| TCI Chemical | C2925 | 3-Cyano-4-methoxy-2-pyridone >98.0%(HPLC)(T) | 21642-98-8 | 25g | $291 | 2026-04-30 | Buy |
| Usbiological | 007995 | N-Demethyl Ricinine | 21642-98-8 | 5g | $418 | 2026-06-03 | Buy |
| Usbiological | 007995 | N-Demethyl Ricinine | 21642-98-8 | 25g | $708 | 2026-06-03 | Buy |
| AstaTech | CL0187 | 4-METHOXY-2-OXO-1,2-DIHYDRO-PYRIDINE-3-CARBONITRILE 97% | 21642-98-8 | 5G | $10 | 2026-04-30 | Buy |
4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile Chemical Properties, Uses, Production
Synthesis
Step 1: A mixture of malononitrile (0.33 g, 5 mmol) and trimethyl orthoformate (0.64 g, 6 mmol) was stirred at 80 °C for 1 hour. The reaction mixture was cooled to room temperature and then a methanol (10 mL) solution of N,N-dimethylformamide dicarboxylate (6 mmol) was added with stirring. The reaction mixture was refluxed for 30 minutes. After cooling, the resulting precipitate was filtered, dried and recrystallized from methanol to give pure 1,1-dicyano-2-methoxy-4-dimethylamino-1,3-butadiene as light red crystals. Yield: 76%, melting point: 130-131 °C. [1] Step 2: Acetic acid (10 mL) was added to the intermediate from the previous step (0.53 g, 3 mmol), and the temperature was increased to 125 °C until the reaction was complete, as monitored by TLC. Excess acetic acid was evaporated under vacuum to obtain crude 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile. The crude product was recrystallized from methanol to give white crystals, which were the target product.
Chemical Properties
Off-white crystalline powder
Uses
N-Demethylricinine is a demethylated metabolite of Ricinine (R495550), an alkaloid extract from the castor-oil plant (Ricinus communalis). N-Demethylricinine is an impurity in the production of Gime racil.
Uses
Used as a intermediate for gimeracil and pharmaceutical application.
4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhongxin Chenshi (Wuhan) Technology Co., Ltd | 18942922096 | 2662561040@qq.com | China | 980 | 58 |
| Zhengzhou Ailfield Chemical Co., Ltd. | 0311-84468392; 15993358503 | 1013053532@qq.com | China | 254 | 58 |
| Zaozhuang Benefit Chemical Co., Ltd. | 0531-69958783 15508681609 | 1948129184@qq.com | China | 207 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Suzhou Highfine Biotech Co., Ltd | 0512-69209928 18796809688 | zhouyingxiang@highfine.com | China | 472 | 75 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 2-hydroxy-4-methoxypyridine-3-carbonitrile
21642-98-8
|
$2.20-8.80 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-07-27 | N-Demethylricinine
21642-98-8
|
$29.00 | 99.11% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | N-Demethylricinine
21642-98-8
|
$29.00 | 99.11% | 10g | TargetMol Chemicals Inc. |
-
- 2-hydroxy-4-methoxypyridine-3-carbonitrile
21642-98-8
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- N-Demethylricinine
21642-98-8
- $29.00
- 99.11%
- TargetMol Chemicals Inc.
-
- N-Demethylricinine
21642-98-8
- $29.00
- 99.11%
- TargetMol Chemicals Inc.
