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3-Cyano-4-methylpyridine

3-Cyano-4-methylpyridine Structure
3-Cyano-4-methylpyridine structure
CAS No.
5444-01-9
Chemical Name:
3-Cyano-4-methylpyridine
Synonyms
NSC 19882;3-Cyano-4-methyL;4-Methylnicotinyl;3-Cyano-4-picoline;4-Methylnicotinotrile;4-METHYLNICOTINONITRILE;3-CYANO-4-METHYLPYRIDINE;3-Cyano-4-methylpyridine >3-Cyano-4-methylpyridine ,98%;4-Methylpyridine-3-carbonitrile
CBNumber:
CB1333509
Molecular Formula:
C7H6N2
Molecular Weight:
118.14
MDL Number:
MFCD00234272
MOL File:
5444-01-9.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:51
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3-Cyano-4-methylpyridine Properties

Melting point 41-44°C
Boiling point 108-111°C 20mm
Density 1.08±0.1 g/cm3(Predicted)
Flash point 108-111°C/20mm
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
pka 2.45±0.18(Predicted)
form powder to crystal
color White to Orange to Green
BRN 112016
InChI InChI=1S/C7H6N2/c1-6-2-3-9-5-7(6)4-8/h2-3,5H,1H3
InChIKey XLAPHZHNODDMDD-UHFFFAOYSA-N
SMILES C1=NC=CC(C)=C1C#N
CAS DataBase Reference 5444-01-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P280h-P305+P351+P338-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-36/38-22
Safety Statements  22-36/37/39-36-26-36/37
RIDADR  3439
Hazard Note  Harmful
HazardClass  6.1
PackingGroup  III
HS Code  29333990
NFPA 704
1
2 0

3-Cyano-4-methylpyridine price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2608 3-Cyano-4-methylpyridine >98.0%(GC) 5444-01-9 1g $54 2025-07-31 Buy
TCI Chemical C2608 3-Cyano-4-methylpyridine >98.0%(GC) 5444-01-9 5g $187 2025-07-31 Buy
TRC C987495 3-Cyano-4-methylpyridine 5444-01-9 500mg $120 2021-12-16 Buy
American Custom Chemicals Corporation CHM0023432 3-CYANO-4-METHYLPYRIDINE 95.00% 5444-01-9 1G $600.79 2021-12-16 Buy
American Custom Chemicals Corporation CHM0023432 3-CYANO-4-METHYLPYRIDINE 95.00% 5444-01-9 5G $832.25 2021-12-16 Buy
Product number Packaging Price Buy
C2608 1g $54 Buy
C2608 5g $187 Buy
C987495 500mg $120 Buy
CHM0023432 1G $600.79 Buy
CHM0023432 5G $832.25 Buy

3-Cyano-4-methylpyridine Chemical Properties,Uses,Production

Uses

3-Cyano-4-methylpyridine, is an intermediate for the synthesis of various pharmaceutical compounds, including inhibitors and anticancer agents. It can be used for the preparation of a series of azaindenoisoquinoline topoisomerase I I inhibitors and potential anticancer agents.

Synthesis

2,6-Dichloro-4-methylnicotinonitrile

875-35-4

3-Cyano-4-methylpyridine

5444-01-9

General procedure for the synthesis of 3-cyano-4-methylpyridine (112) from 3-cyano-4-methyl-2,6-dichloropyridine (Ref. J. Org. Chem. 1960, 25, 560-564): palladium dichloride (50 mg, 0.3 mmol) was added to a degassed 3-cyano-4-methyl-2,6-dichloropyridine (5.0 g, 27 mmol) and sodium acetate (4.5 g, 55 mmol) in a methanol (100 mL) solution. The reaction mixture was stirred under hydrogen (1 atm) atmosphere for 14 hours at room temperature. After completion of the reaction, the precipitate was filtered and washed with methanol (3 x 20 mL). The filtrates were combined, the solvent was removed by evaporation under reduced pressure and chloroform (50 mL) was added to the residue. The chloroform solution was filtered through a thin silica gel pad and the silica gel pad was washed with additional chloroform. The filtrate was evaporated to dryness to afford 3-cyano-4-methylpyridine (112) (2.9 g, 93% yield) as a yellow oil. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.77 (s, 1H), 8.63 (s, J = 6.0 Hz, 1H), 7.3 (d, J = 6.0 Hz, 1H), 2.56 (s, 3H). The resulting 3-cyano-4-methylpyridine (112) can be used in subsequent reactions without further purification.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0146
[3] Patent: EP1348706, 2003, A1. Location in patent: Page/Page column 36
[4] Letters in Organic Chemistry, 2016, vol. 13, # 6, p. 450 - 452

3-Cyano-4-methylpyridine Preparation Products And Raw materials

Raw materials

4-Methyl-3-pyridinecarboxamide 3-cyano-2,6-dibromo-4-methylpyridine ZINC CYANIDE 2,6-Dichloro-4-methylnicotinonitrile 3-Bromo-4-methylpyridine
Methanol Sodium acetate Palladium chloride Hydrogen

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Preparation Products

Methyl 2-(3-cyanopyridin-4-yl)acetate 4-methyl-1-oxidopyridin-1-ium-3-carbonitrile N'-Hydroxy-4-methylpyridine-3-carboximidamide Ethyl 4-(chloroMethyl)nicotinate 4-Ethylnicotinonitrile
4-(bromomethyl)nicotinonitrile

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3-Cyano-4-methylpyridine Suppliers

Global( 275)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20195 58
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29733 60
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29855 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10406 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Accela ChemBio Inc. 		58
Hubei xin bonus chemical co. LTD 		58
Shandong chuangyingchemical Co., Ltd. 		58

View Lastest Price from 3-Cyano-4-methylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Cyano-4-methylpyridine pictures 2025-07-25 3-Cyano-4-methylpyridine
5444-01-9
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
3-Cyano-4-methylpyridine pictures 2024-04-08 3-Cyano-4-methylpyridine
5444-01-9
 US $5.00-0.10 / KG 1KG 98% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
3-Cyano-4-methylpyridine pictures 2021-10-15 3-Cyano-4-methylpyridine
5444-01-9
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited

3-Cyano-4-methylpyridine Spectrum

3-Cyano-4-methylpyridine(5444-01-9)1HNMR

5444-01-9(3-Cyano-4-methylpyridine)Related Search:

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3-CYANO-4-METHYLPYRIDINE 4-METHYLNICOTINONITRILE 3-Cyano-4-picoline 4-Methylnicotinotrile 4-Methylpyridine-3-carbonitrile 3-Pyridinecarbonitrile, 4-methyl- 3-Cyano-4-methylpyridine ,98% 4-Methyl-3-pyridinecarbonitrile 4-Methylnicotinonitrile NSC 19882 3-Cyano-4-methylpyridine > 3-Cyano-4-methyL 3-Cyano-4-methylpyridine ISO 9001：2015 REACH 4-Methylnicotinyl 5444-01-9 5444-1-9 1294-42-9 544-01-9 1294665 5444-10-9 5444-19-1 Heterocycle-Pyridine series Pyridines Pyridine Pyridines derivates