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3-Cyano-4-methylpyridine

3-Cyano-4-methylpyridine Structure
3-Cyano-4-methylpyridine structure
CAS No.
5444-01-9
Chemical Name:
3-Cyano-4-methylpyridine
Synonyms
4-METHYLNICOTINONITRILE;4-Methylpyridine-3-carbonitrile;NSC 19882;3-Cyano-4-methyL;4-Methylnicotinyl;3-Cyano-4-picoline;4-Methylnicotinotrile;3-CYANO-4-METHYLPYRIDINE;3-Cyano-4-methylpyridine >3-Cyano-4-methylpyridine ,98%
CBNumber:
CB1333509
Molecular Formula:
C7H6N2
Molecular Weight:
118.14
MDL Number:
MFCD00234272
MOL File:
5444-01-9.mol
MSDS File:
SDS
Last updated:2026-06-04 16:00:12
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3-Cyano-4-methylpyridine Properties

Melting point 41-44°C
Boiling point 108-111°C 20mm
Density 1.08±0.1 g/cm3(Predicted)
Flash point 108-111°C/20mm
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
pka 2.45±0.18(Predicted)
form powder to crystal
color White to Orange to Green
BRN 112016
InChI InChI=1S/C7H6N2/c1-6-2-3-9-5-7(6)4-8/h2-3,5H,1H3
InChIKey XLAPHZHNODDMDD-UHFFFAOYSA-N
SMILES C1=NC=CC(C)=C1C#N
CAS DataBase Reference 5444-01-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P280h-P305+P351+P338-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38-36/38-22
Safety Statements  22-36/37/39-36-26-36/37
RIDADR  3439
Hazard Note  Harmful
HazardClass  6.1
PackingGroup  III
HS Code  29333990
Limited Quantities 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 0

3-Cyano-4-methylpyridine price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2608 3-Cyano-4-methylpyridine >98.0%(GC) 5444-01-9 1g $43 2026-04-30 Buy
TCI Chemical C2608 3-Cyano-4-methylpyridine >98.0%(GC) 5444-01-9 5g $150 2026-04-30 Buy
AstaTech 59598 3-CYANO-4-METHYLPYRIDINE 97% 5444-01-9 10G $78 2026-04-30 Buy
AstaTech 59598 3-CYANO-4-METHYLPYRIDINE 97% 5444-01-9 50G $233 2026-04-30 Buy
Activate Scientific AS21374 4-Methylnicotinonitrile 98% 5g $20 2026-06-04 Buy
Product number Packaging Price Buy
C2608 1g $43 Buy
C2608 5g $150 Buy
59598 10G $78 Buy
59598 50G $233 Buy
AS21374 5g $20 Buy

3-Cyano-4-methylpyridine Chemical Properties, Uses, Production

Uses

3-Cyano-4-methylpyridine, is an intermediate for the synthesis of various pharmaceutical compounds, including inhibitors and anticancer agents. It can be used for the preparation of a series of azaindenoisoquinoline topoisomerase I I inhibitors and potential anticancer agents.

Synthesis

2,6-Dichloro-4-methylnicotinonitrile

875-35-4

3-Cyano-4-methylpyridine

5444-01-9

General procedure for the synthesis of 3-cyano-4-methylpyridine (112) from 3-cyano-4-methyl-2,6-dichloropyridine (Ref. J. Org. Chem. 1960, 25, 560-564): palladium dichloride (50 mg, 0.3 mmol) was added to a degassed 3-cyano-4-methyl-2,6-dichloropyridine (5.0 g, 27 mmol) and sodium acetate (4.5 g, 55 mmol) in a methanol (100 mL) solution. The reaction mixture was stirred under hydrogen (1 atm) atmosphere for 14 hours at room temperature. After completion of the reaction, the precipitate was filtered and washed with methanol (3 x 20 mL). The filtrates were combined, the solvent was removed by evaporation under reduced pressure and chloroform (50 mL) was added to the residue. The chloroform solution was filtered through a thin silica gel pad and the silica gel pad was washed with additional chloroform. The filtrate was evaporated to dryness to afford 3-cyano-4-methylpyridine (112) (2.9 g, 93% yield) as a yellow oil. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.77 (s, 1H), 8.63 (s, J = 6.0 Hz, 1H), 7.3 (d, J = 6.0 Hz, 1H), 2.56 (s, 3H). The resulting 3-cyano-4-methylpyridine (112) can be used in subsequent reactions without further purification.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1682 - 1697
[2] Patent: US2014/18360, 2014, A1. Location in patent: Paragraph 0146
[3] Patent: EP1348706, 2003, A1. Location in patent: Page/Page column 36
[4] Letters in Organic Chemistry, 2016, vol. 13, # 6, p. 450 - 452

3-Cyano-4-methylpyridine Preparation Products And Raw materials

Raw materials

4-Methyl-3-pyridinecarboxamide 3-cyano-2,6-dibromo-4-methylpyridine ZINC CYANIDE 2,6-Dichloro-4-methylnicotinonitrile 3-Bromo-4-methylpyridine
Methanol Sodium acetate Palladium chloride Hydrogen

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Preparation Products

Methyl 2-(3-cyanopyridin-4-yl)acetate 4-methyl-1-oxidopyridin-1-ium-3-carbonitrile N'-Hydroxy-4-methylpyridine-3-carboximidamide Ethyl 4-(chloroMethyl)nicotinate 4-Ethylnicotinonitrile
4-(bromomethyl)nicotinonitrile

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3-Cyano-4-methylpyridine Suppliers

Global Suppliers ( 278)
Supplier Tel Email Country ProdList Advantage
Zhejiang Jiaguo Biotechnology Co., Ltd 0576-057687838881 13968486607 shxc7755@163.com China 157 58
Sci-Sun Technology CO.,Ltd 18252089365 Krain_kerun@163.com China 2877 58
Shandong Boda Pharmaceutical Co., Ltd 18678253918 15624526479 18678253918@163.com China 39 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Zhejiang Jiaguo Biotechnology Co., Ltd 58
Sci-Sun Technology CO.,Ltd 58
Shandong Boda Pharmaceutical Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Capot Chemical Co., Ltd 66

View Latest Price from 3-Cyano-4-methylpyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Cyano-4-methylpyridine pictures 2026-09-02 3-Cyano-4-methylpyridine
5444-01-9
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
3-Cyano-4-methylpyridine pictures 2026-08-20 3-Cyano-4-methylpyridine
5444-01-9
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
3-Cyano-4-methylpyridine pictures 2026-06-30 3-Cyano-4-methylpyridine
5444-01-9
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd

3-Cyano-4-methylpyridine Spectrum

3-Cyano-4-methylpyridine(5444-01-9)1HNMR

5444-01-9 (3-Cyano-4-methylpyridine) Related Search:

4-Methylpyridine 3-Cyanopyridine 2-Chloro-5-chloromethylpyridine Azamethiphos 2,6-Lutidine
2-Chloro-3-cyanopyridine 2,4,6-Collidine Ethyl 3-cyano-2-mercapto-6-methylisonicotinate 6-Methylpyridine-2-carbonitrile 2-Chloro-3-cyano-4,6-dimethylpyridine
2,6-DIHYDROXY-3-CYANO-4-METHYLPYRIDINE 2,6-Dichloro-4-methylnicotinonitrile 2-Cyano-4-methylpyridine 3-Cyano-4,6-dimethyl-2-mercaptopyridine 3-Cyano-5-methylpyridine
6-Amino-2-methylnicotinonitrile Pyridine-3,4-dicarbonitrile Ethyl 2-chloro-3-cyano-6-methylisonicotinate

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3-CYANO-4-METHYLPYRIDINE 3-Cyano-4-picoline 4-Methylnicotinotrile 3-Pyridinecarbonitrile, 4-methyl- 3-Cyano-4-methylpyridine ,98% 4-Methyl-3-pyridinecarbonitrile 4-Methylnicotinonitrile NSC 19882 3-Cyano-4-methylpyridine > 3-Cyano-4-methyL 3-Cyano-4-methylpyridine ISO 9001：2015 REACH 4-Methylnicotinyl 4-METHYLNICOTINONITRILE 4-Methylpyridine-3-carbonitrile 3-Cyano-4-methylpyridine / 4-Methylnicotinonitrile 5444-01-9 5444-1-9 1294-42-9 544-01-9 1294665 5444-10-9 5444-19-1 Heterocycle-Pyridine series Pyridines Pyridine Pyridines derivates