GO 6983
- CAS No.
- 133053-19-7
- Chemical Name:
- GO 6983
- Synonyms
- CS-674;gǒ 6983;Gδ 6983;GOE 6983;Go6983(96 %);GO6983 GO-6983;GO 6983 USP/EP/BP;Go 6983, 10 mM in DMSO;Gouml 6983, PKC inhibitor;G 6983 - GO 6983 | Goe 6983
- CBNumber:
- CB7498134
- Molecular Formula:
- C26H26N4O3
- Molecular Weight:
- 442.51
- MDL Number:
- MFCD04040031
- MOL File:
- 133053-19-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Gö 6983 ≥97% | G1918 | 500μg | $144 |
| G 6983 ≥97% | G1918 | 1mg | $245 |
| Gö 6983 - CAS 133053-19-7 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes. | 365251 | 500μg | $190 |
| Go 6983 | G0619 | 10MG | $164 |
| Gö 6983 ≥98% | 13311 | 1mg | $54 |
| More product size | |||
| Boiling point | 709.0±60.0 °C(Predicted) |
|---|---|
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: 20 mg/mL, clear, red |
| form | powder |
| pka | 8.02±0.60(Predicted) |
| color | red |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | LLJJDLHGZUOMQP-UHFFFAOYSA-N |
| SMILES | COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933998090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
GO 6983 price More Price(87)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G1918 | Gö 6983 ≥97% | 133053-19-7 | 500μg | $144 | 2026-04-30 | Buy |
| Sigma-Aldrich | G1918 | G 6983 ≥97% | 133053-19-7 | 1mg | $245 | 2026-04-30 | Buy |
| Sigma-Aldrich | 365251 | Gö 6983 - CAS 133053-19-7 - Calbiochem A potent, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC) that inhibits several PKC isozymes. | 133053-19-7 | 500μg | $190 | 2026-04-30 | Buy |
| TCI Chemical | G0619 | Go 6983 | 133053-19-7 | 10MG | $164 | 2026-04-30 | Buy |
| Cayman Chemical | 13311 | Gö 6983 ≥98% | 133053-19-7 | 1mg | $54 | 2026-04-30 | Buy |
GO 6983 Chemical Properties,Uses,Production
Description
Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1 Suppresses stress induced HSP27 disassociation.2 Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4
Uses
Go 6983, is a protein kinase C (PKC) inhibitor.Potent PKC Inhibitor
Uses
GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).
Definition
ChEBI: 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione is a member of indoles and a member of maleimides.
Biological Activity
Broad spectrum protein kinase C (PKC) inhibitor (IC 50 values are 7, 7, 6, 10, 60 and 20000 nM for PKC α , PKC β , PKC γ , PKC δ , PKC ζ and PKC μ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury.
Biochem/physiol Actions
Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).
storage
-20°C
References
[1] MICHAEL GSCHWENDT . Inhibition of protein kinase C μ by various inhibitors. Inhibition from protein kinase c isoenzymes[J]. FEBS Letters, 1996, 392 2: Pages 77-80. DOI:10.1016/0014-5793(96)00785-5
[2] KANEFUSA KATO. Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27[J]. Cell Stress & Chaperones, 2001, 18 1: 16-20. DOI:10.1379/1466-1268(2001)006<0016:pkicss>2.0.co;2
[3] GANESHKUMAR RAJENDRAN. Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency.[J]. The Journal of Biological Chemistry, 2013: 24351-24362. DOI:10.1074/jbc.m113.455725
[4] LINDON H. YOUNG Margaret T W Brian J Balin. Gö 6983: A Fast Acting Protein Kinase C Inhibitor that Attenuates Myocardial Ischemia/Reperfusion Injury[J]. Cardiovascular Therapeutics, 2006, 23 3: 255-272. DOI:10.1111/j.1527-3466.2005.tb00170.x
GO 6983 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19936 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29120 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10457 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
