(5-Bromo-2-chlorophenyl)methanol
- CAS No.
- 149965-40-2
- Chemical Name:
- (5-Bromo-2-chlorophenyl)methanol
- Synonyms
- CAS:149965-40-2;2-Chloro-5-bromobenzyl alcohol;(5-bromo-2-chlorophenyl)methanol;Benzenemethanol,5-bromo-2-chloro-;5-Bromo-2-chlorobenzyl Alcohol >5-BROMO-2-CHLOROBENZYL ALCOHOL 97
- CBNumber:
- CB7499580
- Molecular Formula:
- C7H6BrClO
- Molecular Weight:
- 221.48
- MDL Number:
- MFCD02683548
- MOL File:
- 149965-40-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 92-96 °C (lit.) |
|---|---|
| Boiling point | 295.8±25.0 °C(Predicted) |
| Density | 1.685 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 13.69±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| InChI | 1S/C7H6BrClO/c8-6-1-2-7(9)5(3-6)4-10/h1-3,10H,4H2 |
| InChIKey | SCHBQPIVMBDOQF-UHFFFAOYSA-N |
| SMILES | OCc1cc(Br)ccc1Cl |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| HS Code | 2906299090 |
| Storage Class | 11 - Combustible Solids |
(5-Bromo-2-chlorophenyl)methanol price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 525723 | 5-Bromo-2-chlorobenzyl alcohol 97% | 149965-40-2 | 5g | $84.5 | 2023-01-07 | Buy |
| TCI Chemical | B3946 | 5-Bromo-2-chlorobenzyl Alcohol >98.0%(GC) | 149965-40-2 | 1g | $59 | 2026-04-30 | Buy |
| TCI Chemical | B3946 | 5-Bromo-2-chlorobenzyl Alcohol >98.0%(GC) | 149965-40-2 | 5g | $186 | 2026-04-30 | Buy |
| Apolloscientific | OR71193 | 5-Bromo-2-chlorobenzyl alcohol >98% | 149965-40-2 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR71193 | 5-Bromo-2-chlorobenzyl alcohol >98% | 149965-40-2 | 25g | $63 | 2026-06-04 | Buy |
(5-Bromo-2-chlorophenyl)methanol Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powder
Uses
5-Bromo-2-chlorobenzyl alcohol is also referred to as (5-bromo-2-chlorophenyl)methanol (IUPAC name).
General Description
5-Bromo-2-chlorobenzyl alcohol is also referred to as (5-bromo-2-chlorophenyl)methanol (IUPAC name).
Synthesis
21739-92-4
149965-40-2
5-Bromo-2-chlorobenzoic acid (5 g, 21.23 mmol) was dissolved in tetrahydrofuran (THF, 10 mL) at 0 °C and 10 M borane-methyl sulfide complex (2.123 mL, 21.23 mmol) was added slowly. The reaction system was gradually warmed to 23 °C with continuous stirring for 14 hours. Upon completion of the reaction, the reaction mixture was cooled and an additional 10 M borane-methyl sulfide complex (1.062 mL, 10.62 mmol) was added. Subsequently, the reaction mixture was cooled in an ice water bath and methanol (2.00 mL) was added slowly and dropwise to quench the reaction. After the production of bubbles essentially ceased, the volatile solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (EtOAc, 1 mL) and washed with saturated aqueous sodium bicarbonate. The aqueous phase was back-extracted with ethyl acetate (50 mL) and the combined organic phases were washed sequentially with water (5 mL) and saturated aqueous sodium chloride. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 2-chloro-5-bromobenzyl alcohol (4.62 g, 98% yield). The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 7.70 (s, 1H), 7.40 (d, J = 8.28Hz, 1H), 7.28 (d, J = 8.53Hz, 1H), 4.66 (s, 2H).
References
[1] Journal of Organic Chemistry, 2006, vol. 71, # 4, p. 1711 - 1714
[2] Patent: WO2018/109648, 2018, A1. Location in patent: Page/Page column 96
[3] Patent: WO2012/172566, 2012, A2. Location in patent: Page/Page column 52
[4] Patent: WO2013/38429, 2013, A2. Location in patent: Page/Page column 48
[5] Patent: EP2755722, 2017, B1. Location in patent: Paragraph 0105
(5-Bromo-2-chlorophenyl)methanol Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin Jinyuda Chemical Co., Ltd. | 022-58013646 13011382049 | sales@jinyudachem.com | China | 1976 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from (5-Bromo-2-chlorophenyl)methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-27 | 5-BROMO-2-CHLOROBENZYL ALCOHOL 97
149965-40-2
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 5-BROMO-2-CHLOROBENZYL ALCOHOL 97
149965-40-2
- $1.00
- 99%
- Career Henan Chemical Co
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