4-Chloro-6-methyl-2-(methylthio)pyrimidine
- CAS No.
- 17119-73-2
- Chemical Name:
- 4-Chloro-6-methyl-2-(methylthio)pyrimidine
- Synonyms
- NSC 48354;4-Chloro-6-methyl-2-(methylthio);4-Chloro-6-methyl-2-methylsulfany;4,6-dichloro-2-MethylpyriMidine-1-thiol;4-Chloro-6-methyl-2-(methylthio)pyrimidine;4-CHLORO-6-METHYL-2-METHYLSULFANYL-PYRIMIDINE;Pyrimidine, 4-chloro-6-methyl-2-(methylthio)-;4-Chloro-6-methyl-2-(methylthio)pyrimidine >4-chloro-6-methyl-2-(methylthio)pyrimidine(SALTDATA: FREE)
- CBNumber:
- CB7663118
- Molecular Formula:
- C6H7ClN2S
- Molecular Weight:
- 174.65
- MDL Number:
- MFCD00023233
- MOL File:
- 17119-73-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 37-38℃ |
|---|---|
| Boiling point | 147°C/32mmHg(lit.) |
| Density | 1.30±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Sparingly), MEthanol (Slightly) |
| form | Solid |
| pka | 0.16±0.30(Predicted) |
| color | Pale Yellow |
| InChI | InChI=1S/C6H7ClN2S/c1-4-3-5(7)9-6(8-4)10-2/h3H,1-2H3 |
| InChIKey | ALMBOXQFPLQVLF-UHFFFAOYSA-N |
| SMILES | C1(SC)=NC(C)=CC(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 36/37 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
4-Chloro-6-methyl-2-(methylthio)pyrimidine price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S344354 | 4-CHLORO-6-METHYL-2-METHYLTHIOPYRIMIDINE AldrichCPR | 17119-73-2 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | S344354 | 4-CHLORO-6-METHYL-2-METHYLTHIOPYRIMIDINE Aldrich | 17119-73-2 | 250mg | $179 | 2024-03-01 | Buy |
| TCI Chemical | C2952 | 4-Chloro-6-methyl-2-(methylthio)pyrimidine >98.0%(GC) | 17119-73-2 | 1g | $314 | 2026-04-30 | Buy |
| Usbiological | 267656 | 4-Chloro-6-methyl-2-(methylthio)pyrimidine Asreported | 17119-73-2 | 5g | $744 | 2026-06-03 | Buy |
| Usbiological | 267656 | 4-Chloro-6-methyl-2-(methylthio)pyrimidine Asreported | 17119-73-2 | 10g | $1238 | 2026-06-03 | Buy |
4-Chloro-6-methyl-2-(methylthio)pyrimidine Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
4-Chloro-6-methyl-2-(methylthio)pyrimidine has been used in the synthesis of 4-chloro-2-(3,5-dimethyl-1h-pyrazol-1-yl)-6-methylpyrimidine.
Synthesis
6328-58-1
17119-73-2
A. Synthesis of 6-methyl-2-methylthio-4-chloropyrimidine: 6-methyl-4-hydroxy-2-methylthio-pyrimidine (9.20 g, 59 mmol) was mixed with phosphorus trichloride (60 mL) and heated to reflux for 3 hours. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into crushed ice. The aqueous phase mixture was extracted with ethyl acetate and the organic layer was washed sequentially with saturated aqueous sodium bicarbonate and water and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to give 6-methyl-2-methylthio-4-chloropyrimidine (8.27 g, 80% yield) as a white solid with a melting point of 37-38°C. The solvent was removed by concentration under reduced pressure.
References
[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 6, p. 1146 - 1157
[2] Patent: US5863924, 1999, A
[3] Patent: US5958934, 1999, A
[4] Patent: US5952331, 1999, A
[5] Patent: EP901474, 2006, B1. Location in patent: Page/Page column 26
4-Chloro-6-methyl-2-(methylthio)pyrimidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yuqing Chemical Co., Ltd. | +86-13816254020 +86-18601759286 | penny.xu@tianqing-chem.com | China | 66 | 58 |
| Shandong Xuanshuo Pharmaceutical Technology Co. LTD | 15269103900 | suchangzhou@shiningpharm.com | China | 384 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from 4-Chloro-6-methyl-2-(methylthio)pyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-05-17 | 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine
17119-73-2
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 4-Chloro-6-methyl-2-(methylthio)pyrimidine
17119-73-2
|
$1.00 | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- 4-chloro-6-methyl-2-(methylsulfanyl)pyrimidine
17119-73-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-Chloro-6-methyl-2-(methylthio)pyrimidine
17119-73-2
- $1.00
- 98%
- Career Henan Chemical Co
