4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- CAS No.
- 4489-34-3
- Chemical Name:
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
- Synonyms
- DLMSP;nsc 45040;VITAS-BB TBB000242;4,6-dichloro-2-mesyl-pyrimidine;(benzenesulfonylthio)sulfonylbenzene;6-Dichloro-2-MethylsulfonylpyriMidine;4,6-DIMETHY-2-METHYLSULFONYLPYRIMIDINE;4,6-DICHLORO-2-METHANESULFONYLPYRIMIDINE;2-(methylsulfonyl)-4,6-dichloropyrimidine;4,6-DICHLORO-2-(METHYLSULFONYL)PYRIMIDINE
- CBNumber:
- CB6667492
- Molecular Formula:
- C5H4Cl2N2O2S
- Molecular Weight:
- 227.07
- MDL Number:
- MFCD00672147
- MOL File:
- 4489-34-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4,6-Dichloro-2-(methylsulfonyl)pyrimidine >98.0%(GC) | D4135 | 1g | $25 |
| 4,6-Dichloro-2-(methylsulfonyl)pyrimidine >98.0%(GC) | D4135 | 5g | $82 |
| 4,6-Dichloro-2-methylsulfonylpyrimidine Asreported | 296032 | 5g | $378 |
| 4,6-Dichloro-2-methylsulfonylpyrimidine Asreported | 296032 | 10g | $526 |
| 4,6-Dichloro-2-methylsulfonylpyrimidine Asreported | 296032 | 25g | $721 |
| More product size | |||
| Melting point | 117-118°C |
|---|---|
| Boiling point | 402.3±48.0 °C(Predicted) |
| Density | 1.604 |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -9.08±0.30(Predicted) |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C5H4Cl2N2O2S/c1-12(10,11)5-8-3(6)2-4(7)9-5/h2H,1H3 |
| InChIKey | DROUVIKCNOHKBA-UHFFFAOYSA-N |
| SMILES | C1(S(C)(=O)=O)=NC(Cl)=CC(Cl)=N1 |
| CAS DataBase Reference | 4489-34-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS07,GHS08,GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H314-H371-H372-H351-H335-H225 | |||||||||
| Precautionary statements | P501-P260-P270-P202-P240-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P308+P311-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26-24/25 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
|
4,6-Dichloro-2-(methylsulfonyl)pyrimidine price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D4135 | 4,6-Dichloro-2-(methylsulfonyl)pyrimidine >98.0%(GC) | 4489-34-3 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | D4135 | 4,6-Dichloro-2-(methylsulfonyl)pyrimidine >98.0%(GC) | 4489-34-3 | 5g | $82 | 2026-04-30 | Buy |
| Usbiological | 296032 | 4,6-Dichloro-2-methylsulfonylpyrimidine Asreported | 4489-34-3 | 5g | $378 | 2026-06-03 | Buy |
| Usbiological | 296032 | 4,6-Dichloro-2-methylsulfonylpyrimidine Asreported | 4489-34-3 | 10g | $526 | 2026-06-03 | Buy |
| Usbiological | 296032 | 4,6-Dichloro-2-methylsulfonylpyrimidine Asreported | 4489-34-3 | 25g | $721 | 2026-06-03 | Buy |
4,6-Dichloro-2-(methylsulfonyl)pyrimidine Chemical Properties,Uses,Production
Chemical Properties
White solid
Synthesis
6299-25-8
4489-34-3
The general procedure for the synthesis of 4,6-dichloro-2-(methylsulfonyl)pyrimidines from 4,6-dichloro-2-methylthioalkylpyrimidines is as follows: Example 27: Synthesis of 4,6-dichloro-2-(methylsulfonyl)pyrimidine Commercially available 4,6-dichloro-2-methylsulfanylpyrimidine (Aldrich, 21.0 g, 107.0 mmol, 1 eq.) was dissolved in dichloromethane and cooled in an ice bath. Subsequently, 3-chloroperoxybenzoic acid (60.0 g, 77% wt, 268.0 mmol, 2.5 eq.) was added in batches. The resulting white suspension was stirred at room temperature for 4 hours. Upon completion of the reaction, it was washed sequentially with a mixture of 1 M sodium thiosulfate solution and saturated sodium bicarbonate solution (1:1, v/v, 200 mL x 3), saturated sodium bicarbonate solution (100 mL x 3) and brine (100 mL x 1). The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The product was dried under high vacuum overnight to give the title compound EPO27 as a white solid (22.0 g, 91% yield). Thin layer chromatography Rf value was 0.20 (unfolding agent: 20% ethyl acetate/hexane); mass spectrum m/z 227 (calculated value 227, corresponding to molecular formula C5H4Cl2N2O2S+).
References
[1] Patent: WO2007/14250, 2007, A2. Location in patent: Page/Page column 17-18
[2] Patent: WO2007/87245, 2007, A2. Location in patent: Page/Page column 27
[3] Patent: WO2007/87246, 2007, A2. Location in patent: Page/Page column 27
[4] Patent: WO2008/13807, 2008, A2. Location in patent: Page/Page column 6
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 28, p. 8153 - 8157
4,6-Dichloro-2-(methylsulfonyl)pyrimidine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3961 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +86-18530059196 | sale04@alfachem.cn | China | 9636 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
View Lastest Price from 4,6-Dichloro-2-(methylsulfonyl)pyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-05-23 | 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3
|
$50.00-100.00 | 1kg | 99% | 20 tons | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2023-11-13 | 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3
|
1KG | 99% | 10tons | Wuhan Boye Science And Technology Development Co., Ltd. | ||
 |
2020-05-15 | 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3
- $50.00-100.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3
- $0.00
- 99%
- Wuhan Boye Science And Technology Development Co., Ltd.
-
- 4,6-Dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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