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| | N-(Trimethylsilyl)acetamide Basic information |
| | N-(Trimethylsilyl)acetamide Chemical Properties |
| Melting point | 46-49 °C(lit.) | | Boiling point | 84 °C18 mm Hg(lit.) | | density | 0.859±0.06 g/cm3(Predicted) | | Fp | 135 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | Chloroform, DMSO, Methanol | | pka | 18.23±0.46(Predicted) | | form | Crystalline Mass | | color | White to yellow | | Water Solubility | reacts | | Sensitive | Moisture Sensitive | | Hydrolytic Sensitivity | 7: reacts slowly with moisture/water | | BRN | 741928 | | Stability: | Moisture Sensitive | | InChI | 1S/C5H13NOSi/c1-5(7)6-8(2,3)4/h1-4H3,(H,6,7) | | InChIKey | LWFWUJCJKPUZLV-UHFFFAOYSA-N | | SMILES | CC(=O)N[Si](C)(C)C | | CAS DataBase Reference | 13435-12-6(CAS DataBase Reference) | | EPA Substance Registry System | Acetamide, N-(trimethylsilyl)- (13435-12-6) |
| Hazard Codes | Xi-F,Xi,F | | Risk Statements | 36/37/38-11 | | Safety Statements | 37/39-26 | | RIDADR | 1325 | | WGK Germany | 3 | | RTECS | AD0250000 | | F | 10-21 | | TSCA | TSCA listed | | HazardClass | 4.1 | | PackingGroup | III | | HS Code | 29319090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2 |
| | N-(Trimethylsilyl)acetamide Usage And Synthesis |
| Chemical Properties | WHITE TO YELLOWISH CRYSTALLINE MASS | | Uses | N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670). | | General Description | The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied. | | Purification Methods | Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.] |
| | N-(Trimethylsilyl)acetamide Preparation Products And Raw materials |
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