Ticlopidine
- CAS No.
- 55142-85-3
- Chemical Name:
- Ticlopidine
- Synonyms
- TICIOPIDINE;pcr5332;PCR 5332;Ticlosin;Anagregal;Caudaline;TICLOPIDINE;PCR 5332|||Ticlid;5-(2-Chlorobenzyl);Ticlopidine USP/EP/BP
- CBNumber:
- CB7674370
- Molecular Formula:
- C14H14ClNS
- Molecular Weight:
- 263.79
- MDL Number:
- MFCD00661081
- MOL File:
- 55142-85-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 210-212 °C |
|---|---|
| Boiling point | 117-120 °C(Press: 0.5 Torr) |
| Density | 1.273±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.10±0.20(Predicted) |
| color | Off-White to Pale Yellow |
| CAS DataBase Reference | 55142-85-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | OM90ZUW7M1 |
| ATC code | B01AC05 |
| NIST Chemistry Reference | Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro-(55142-85-3) |
| EPA Substance Registry System | Thieno[3,2-c]pyridine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydro- (55142-85-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Ticlopidine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0018717 | Ticlopidine ≥98% | 55142-85-3 | 100mg | $68 | 2026-06-04 | Buy |
| ChemScene | CS-0018717 | Ticlopidine ≥98% | 55142-85-3 | 250mg | $85 | 2026-06-04 | Buy |
| ChemScene | CS-0018717 | Ticlopidine ≥98% | 55142-85-3 | 1g | $213 | 2026-06-04 | Buy |
| ChemScene | CS-0018717 | Ticlopidine ≥98% | 55142-85-3 | 5g | $750 | 2026-06-04 | Buy |
| Matrix Scientific | 307526 | 5-(2-Chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine | 55142-85-3 | 100.00mg | $80 | 2026-05-19 | Buy |
Ticlopidine Chemical Properties, Uses, Production
Originator
Ticlid,Millot,France,1978
Uses
Ticlopidine suppresses aggregation of thrombocytes and possesses antiaggregant activity. It is believed that its action is connected to its effect on thrombocyte membranes and the reduction in quantity of released adenosine diphosphate and serotonin, which facilitate aggregation of thrombocytes. In wide-ranging clinical trials, ticlopidine presented a number of advantages compared to aspirin.
Uses
Ticlopidine is an antiplatelet drug for the treatment of ischemic heart diseases.
Definition
ChEBI: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group.
Manufacturing Process
A solution of thieno[3,2-c]pyridine (13.5 g; 0.1 mol) and 2-chlorobenzyl
chloride (17.7 g) in acetonitrile (150 ml) is boiled during 4 hours.
After evaporation of the solvent, the solid residue consists of 5-(2-
chlorobenzyl)-thieno[3,2-c]pyridinium chloride which melts at 166°C
(derivative n° 30). This compound is taken up into a solution comprising
ethanol (300 ml) and water (100 ml). Sodium borohydride (NaBH4)(20 g) is
added portionwise to the solution maintained at room temperature. The
reaction medium is maintained under constant stirring during 12 hours and is
then evaporated. The residue is taken up into water and made acidic with
concentrated hydrochloric acid to destroy the excess reducing agent. The
mixture is then made alkaline with ammonia and extracted with ether. The
ether solution is washed with water, dried and evaporated. The oily residue is
dissolved in isopropanol (50 ml) and hydrochloric acid in ethanol solution is
then added thereto.
After filtration and recrystallization from ethanol, there are obtained 5-(2-
chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride crystals
(yield: 60%) having a melting point (Koefler block) of 190°C.
brand name
4-c-32 53-32-c;Aplaquette;Derivatives;Klodin;Opteron;Panaldine;Tcp;Ticlidan;Ticlodix;Ticlodone;Ticlopedine;Ticlosan;Tiklid;Tiklyd;Tilcid.
Therapeutic Function
Platelet aggregation inhibitor
World Health Organization (WHO)
Ticlopidine, an inhibitor of platelet aggregation, was introduced in 1978 for use as an antithrombotic agent. By 1982 its use had been associated with cases of agranulocytosis, severe leucopenia and impaired haemostasis. The drug remains available in most countries in which it was approved with appropriate warnings in the product information.
General Description
Ticlopidine, 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c]pyridine hydrochloride(Ticlid), is useful in reducing cardiac events in patients withunstable angina and cerebrovascular events in secondaryprevention of stroke. It belongs to the thienopyridine classand facilitated the development of clopidogrel. One of thedrawbacks to this agent is its side effect profile, whichincludes neutropenia, and patients receiving this antithromboticshould have their blood levels monitored. Its mechanismof action is similar to that of clopidogrel, in that itinhibits the purinergic receptors on platelets.
Synthesis
Ticlopidine, 5-(o-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (24.2.1), is synthesized in many different ways. The first way consists of N-alkylation of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine with 2-chlorobenzylchloride.
References
[1] Patent: WO2005/87779, 2005, A1. Location in patent: Page/Page column 22-23
Ticlopidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
View Latest Price from Ticlopidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Ticlopidine
55142-85-3
|
$32.00-97.00 | 99.67% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-09 | Ticlopidine
55142-85-3
|
$1.00 | 1KG | 85.0-99.8% | 20tons | Career Henan Chemical Co |
-
- Ticlopidine
55142-85-3
- $32.00-97.00
- 99.67%
- TargetMol Chemicals Inc.
-
- Ticlopidine
55142-85-3
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
