4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
- CAS No.
- 16694-17-0
- Chemical Name:
- 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
- Synonyms
- Einecs 240-739-8;4-bromo-3-thenoic acid;4-Bromo-3-carboxythiophene;4-Bromothiophenecarboxylicacid;4-Bromo-3-thiophenecarboxylicacid;4-Bromothiophene-3-carvoxylic acid;4-BROMOTHIOPHENE-3-CARBOXYLIC ACID;3-Bromo-4-thiophenecarboxylic acid;3-Thiophenecarboxylic acid, 4-broMo-;4-Bromo-3-thiophenecarboxylic acid 97%
- CBNumber:
- CB7704949
- Molecular Formula:
- C5H3BrO2S
- Molecular Weight:
- 207.05
- MDL Number:
- MFCD01233020
- MOL File:
- 16694-17-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Bromo-3-thiophenecarboxylic acid 97% | 732214 | 1g | $126 |
| 4-Bromothiophene-3-carboxylic acid Asreported | 261968 | 500mg | $360 |
| 4-Bromothiophene-3-carboxylic acid Asreported | 261968 | 1g | $495 |
| 4-Bromothiophene-3-carboxylic acid Asreported | 261968 | 2g | $718 |
| 4-Bromothiophene-3-carboxylic acid Asreported | 261968 | 5g | $1161 |
| More product size | |||
| Melting point | 157-159℃ |
|---|---|
| Boiling point | 318.0±27.0 °C(Predicted) |
| Density | 1.923±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | 3.63±0.20(Predicted) |
| color | Off-white/faint brown |
| InChI | InChI=1S/C5H3BrO2S/c6-4-2-9-1-3(4)5(7)8/h1-2H,(H,7,8) |
| InChIKey | APBIZVFQQBCAAT-UHFFFAOYSA-N |
| SMILES | C1SC=C(Br)C=1C(O)=O |
| FDA UNII | FX6W43FRG7 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501 |
| Hazard Codes | Xi |
| WGK Germany | 2 |
| Hazard Note | Irritant |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
4-BROMOTHIOPHENE-3-CARBOXYLIC ACID price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 732214 | 4-Bromo-3-thiophenecarboxylic acid 97% | 16694-17-0 | 1g | $126 | 2026-04-30 | Buy |
| Usbiological | 261968 | 4-Bromothiophene-3-carboxylic acid Asreported | 16694-17-0 | 500mg | $360 | 2026-06-03 | Buy |
| Usbiological | 261968 | 4-Bromothiophene-3-carboxylic acid Asreported | 16694-17-0 | 1g | $495 | 2026-06-03 | Buy |
| Usbiological | 261968 | 4-Bromothiophene-3-carboxylic acid Asreported | 16694-17-0 | 2g | $718 | 2026-06-03 | Buy |
| Usbiological | 261968 | 4-Bromothiophene-3-carboxylic acid Asreported | 16694-17-0 | 5g | $1161 | 2026-06-03 | Buy |
4-BROMOTHIOPHENE-3-CARBOXYLIC ACID Chemical Properties,Uses,Production
Synthesis
3141-26-2
124-38-9
16694-17-0
Cool 100 mL of ether to -78°C under a nitrogen atmosphere. A 1.6 M n-butyllithium solution (28.4 mL) was slowly added. Subsequently, a solution of 3,4-dibromothiophene (10 g, 41.3 mmol) dissolved in 50 mL of ether was added dropwise over 10 min. The reaction temperature was maintained at -78 °C and stirring was continued for 10 min before an excess (>50 g) of fresh powdered dry ice (CO) was added. The reaction mixture was stirred at -78°C for 1 hour, then 30 mL of 1 M NaOH solution (pre-diluted with 100 mL of water) was slowly added (note: CO will be released). Gradually increase the temperature until the ice melts. Separate the organic and aqueous phases and extract the ether phase with 25 mL of 1 N NaOH solution. Combine all aqueous phases and acidify with 100 mL of 1 N HCl solution to pH < 7. Collect the precipitated white precipitate by filtration, wash with water, and dry in a vacuum oven to give 4-bromothiophene-3-carboxylic acid as a white solid (5.8 g, 68% yield).
References
[1] Pharmazie, 2006, vol. 61, # 11, p. 901 - 907
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994, # 19, p. 2735 - 2744
[3] Patent: WO2006/3096, 2006, A1. Location in patent: Page/Page column 71-72
[4] Patent: US2013/116233, 2013, A1. Location in patent: Paragraph 1018; 1019
[5] Patent: WO2014/140086, 2014, A1. Location in patent: Page/Page column 68-69
4-BROMOTHIOPHENE-3-CARBOXYLIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-15225627621 +86-13213167925 | jiuyitime@fdachem.com | China | 16505 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | info@chemia-pharm.com | CHINA | 310 | 58 | |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
View Lastest Price from 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-02 | 4-Bromothiophene-3-carboxylic acid
16694-17-0
|
$1.10-9.90 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-11-18 | 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
16694-17-0
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-07-06 | 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
16694-17-0
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- 4-Bromothiophene-3-carboxylic acid
16694-17-0
- $1.10-9.90
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
16694-17-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-BROMOTHIOPHENE-3-CARBOXYLIC ACID
16694-17-0
- $1.00
- 95%
- Career Henan Chemical Co
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