ORIENTIN
- CAS No.
- 28608-75-5
- Chemical Name:
- ORIENTIN
- Synonyms
- LUTEOLIN-8-C-GLUCOSIDE;lutexin;Polygonin;ORIENTINE;Luteolin 8-C-β-D-glucopyranoside;ORIENTIN;Aids026706;Aids-026706;ORIENTIN(P);ORIENTIN,NA
- CBNumber:
- CB7710333
- Molecular Formula:
- C21H20O11
- Molecular Weight:
- 448.38
- MDL Number:
- MFCD00017432
- MOL File:
- 28608-75-5.mol
- TDS File:
- TDS
| Melting point | 260-285°C |
|---|---|
| Boiling point | 816.1±65.0 °C(Predicted) |
| Density | 1.759±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | 1 M NaOH: soluble1mg/mL, clear, yellow-orange |
| pka | 6.24±0.40(Predicted) |
| form | powder |
| color | yellow |
| Stability | Hygroscopic |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | PLAPMLGJVGLZOV-FYNBPVOANA-N |
| SMILES | C12OC(=CC(=O)C=1C(=CC(O)=C2[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)O)C1C=CC(O)=C(O)C=1 |&1:12,13,15,16,18,r| |
| LogP | 1.580 (est) |
| FDA UNII | IAX93XCW6C |
| UNSPSC Code | 85151701 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DJ3009300 | |||||||||
| HS Code | 29389090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
ORIENTIN price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O9765 | Orientin ≥97% (HPLC) | 28608-75-5 | 1mg | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | 03810585 | Orientin primary pharmaceutical reference standard | 28608-75-5 | 10mg | $742 | 2026-04-30 | Buy |
| TCI Chemical | O0503 | Orientin | 28608-75-5 | 25MG | $73 | 2026-04-30 | Buy |
| TCI Chemical | O0503 | Orientin | 28608-75-5 | 100MG | $183 | 2026-04-30 | Buy |
| Cayman Chemical | 25143 | Orientin ≥95% | 28608-75-5 | 25mg | $68 | 2026-04-30 | Buy |
ORIENTIN Chemical Properties,Uses,Production
Description
Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC50 value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 μg/ml and a cytotoxic concentration (CC50) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration.
Chemical Properties
Yellow powder
Uses
Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects.
Definition
ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8.
in vivo
Orientin (0.1–10 mg/kg for p.o.;once) inhibits allergic reaction in PCA mouse model[1].
Orientin (10–40 mg/kg for i.p.;once daily for 12 days) has an anti-neuroinflammatory effect in SNL rat model[2].
| Animal Model: | PCA mouse model[1] |
| Dosage: | 0.1–10 mg/kg |
| Administration: | Oral gavage (p.o.); Euthanized mouse after 1 h |
| Result: | Significantly suppressed PCA reactions in PCA mouse model. |
| Animal Model: | SNL rat model[2] |
| Dosage: | 10, 20, 40 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Once daily for 12 days |
| Result: | Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model. Decreased the levels of IL-6, IL-1β and TNF-α. Increased the level of anti-inflammatory IL-10. Down-regulated the level of MDA. |
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] NAN WU. Antioxidant activities of extracts and main components of Pigeonpea [Cajanus cajan (L.) Millsp.] leaves.[J]. Molecules, 2009, 14 3: 1032-1043. DOI: 10.3390/molecules14031032
[3] YAO-LAN LI . Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge[J]. Journal of ethnopharmacology, 2002, 79 3: Pages 365-368. DOI: 10.1016/s0378-8741(01)00410-x
[4] WONHWA LEE Jong S B Sae Kwang Ku. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo[J]. Vascular pharmacology, 2014, 62 1: Pages 3-14. DOI: 10.1016/j.vph.2014.04.006
ORIENTIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Feiyu Biological Technology CO.,LTD | 0513-68819626 15152877458 | feiyubio@163.com | China | 4807 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
View Lastest Price from ORIENTIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Orientin
28608-75-5
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2023-02-13 | Orientin
28608-75-5
|
$90.00 | 1kg | 99% | 80MT | Hebei baicao biology science and technology co., ltd | |
 |
2021-07-13 | Orientine
28608-75-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
