- Orientin
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- $0.00 / 20mg
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2023-02-24
- CAS:28608-75-5
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Orientin
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- $90.00 / 1kg
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2023-02-13
- CAS:28608-75-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 80MT
- Orientine
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- $15.00 / 1KG
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2021-07-13
- CAS:28608-75-5
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | ORIENTIN Basic information |
| | ORIENTIN Chemical Properties |
| Melting point | 260-285°C | | Boiling point | 816.1±65.0 °C(Predicted) | | density | 1.759±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | 1 M NaOH: soluble1mg/mL, clear, yellow-orange | | pka | 6.24±0.40(Predicted) | | form | powder | | color | yellow | | Stability: | Hygroscopic | | InChIKey | PLAPMLGJVGLZOV-FYNBPVOANA-N | | SMILES | C12OC(=CC(=O)C=1C(=CC(O)=C2[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)O)C1C=CC(O)=C(O)C=1 |&1:12,13,15,16,18,r| | | LogP | 1.580 (est) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | DJ3009300 | | HS Code | 29389090 |
| | ORIENTIN Usage And Synthesis |
| Description | Orientin is a flavone glycoside originally isolated from P. orientale that has diverse biological activities, including antioxidant, antibacterial, and anti-inflammatory properties. Orientin scavenges 2,2-diphenyl-1-picryl-hydrazyl (DPPH; ) radicals with an IC50 value of 316.21 μg/ml. It also decreases the cytopathic effects of parainfluenza type 3 virus with an IC50 value of 11.7 μg/ml and a cytotoxic concentration (CC50) value of 375 μg/ml in Hep-2 cells. Orientin (5-40 μM) inhibits LPS-induced barrier disruption, decreases the expression of toll-like receptor 4 (TLR4), phosphorylated p38, and NF-κB, and decreases TNF-α production and IL-6 secretion in a dose-dependent manner in human umbilical vein endothelial cells (HUVECs). It also prolongs survival in a mouse model of LPS-induced lethal endotoxemia when administered at a dose of 36 μg/animal 12 hours after LPS administration. | | Chemical Properties | Yellow powder | | Uses | Orientin is a flavone, a chemical flavonoid compound. Orientin have been investigated for its anti-oxidant, antihypertensive and antihyperlipidemic effects. | | Definition | ChEBI: A C-glycosyl compound that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 8. | | in vivo | Orientin (0.1–10 mg/kg for p.o.;once) inhibits allergic reaction in PCA mouse model[1].
Orientin (10–40 mg/kg for i.p.;once daily for 12 days) has an anti-neuroinflammatory effect in SNL rat model[2]. | Animal Model: | PCA mouse model[1] | | Dosage: | 0.1–10 mg/kg | | Administration: | Oral gavage (p.o.); Euthanized mouse after 1 h | | Result: | Significantly suppressed PCA reactions in PCA mouse model. |
| Animal Model: | SNL rat model[2] | | Dosage: | 10, 20, 40 mg/kg | | Administration: | Intraperitoneal injection (i.p.); Once daily for 12 days | | Result: | Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model.
Decreased the levels of IL-6, IL-1β and TNF-α.
Increased the level of anti-inflammatory IL-10.
Down-regulated the level of MDA.
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| | References | [1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] NAN WU. Antioxidant activities of extracts and main components of Pigeonpea [Cajanus cajan (L.) Millsp.] leaves.[J]. Molecules, 2009, 14 3: 1032-1043. DOI: 10.3390/molecules14031032
[3] YAO-LAN LI . Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge[J]. Journal of ethnopharmacology, 2002, 79 3: Pages 365-368. DOI: 10.1016/s0378-8741(01)00410-x
[4] WONHWA LEE Jong S B Sae Kwang Ku. Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo[J]. Vascular pharmacology, 2014, 62 1: Pages 3-14. DOI: 10.1016/j.vph.2014.04.006 |
| | ORIENTIN Preparation Products And Raw materials |
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