Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- CAS No.
- 10128-91-3
- Chemical Name:
- Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate
- Synonyms
- SPECS AE-508/36398048;Methyl2-hydroxynicotinate,97%;Methyl 6-hydroxypyridin-3-carboxylate;2-Hydroxy-nicotinic acid methyl ester;1,2-Dihydro-3-(methoxycarbonyl)-2-oxopyridine;Methyl 2-oxo-l,2-dihydropyridine-3-carboxylate;METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate;3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-, methyl ester;METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE ISO 9001：2015 REACH
- CBNumber:
- CB7717675
- Molecular Formula:
- C7H7NO3
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD00661282
- MOL File:
- 10128-91-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR16841 | Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate 98% | 10128-91-3 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS35494 | Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate 97% | 10128-91-3 | 1g | $27 | 2026-06-04 | Buy |
| Activate Scientific | AS35494 | Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate 97% | 10128-91-3 | 5g | $52 | 2026-06-04 | Buy |
| Apolloscientific | OR16841 | Methyl 1,2-dihydro-2-oxopyridine-3-carboxylate 98% | 10128-91-3 | 25g | $230 | 2026-06-04 | Buy |
| Activate Scientific | AS35494 | Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate 97% | 10128-91-3 | 25g | $143 | 2026-06-04 | Buy |
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Chemical Properties, Uses, Production
Uses
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.
Synthesis
67-56-1
609-71-2
10128-91-3
Sulfuric acid (15 mL) and toluene (100 mL) were added to a concentrated solution of 2-hydroxynicotinic acid (50 g) in methanol (500 mL). The reaction mixture was stirred at room temperature for 28 hours before a Dean-Stark reflux device was installed and the reaction solution was neutralized with aqueous potassium carbonate, followed by evaporation of the solvent. Saturated aqueous ammonium chloride and chloroform were added to the residue, the organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to afford methyl 2-hydroxynicotinate (46 g, 84% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ: 3.92 (s, 3H), 6.45 (dd, J=7.3,6.4 Hz, 1H), 7.78 (dd, J=6.4,2.4 Hz, 1H). 8.29 (dd, J=7.3,2.4Hz, 1H).
References
[1] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 41
[2] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 59-60
[3] European Journal of Medicinal Chemistry, 2012, vol. 52, p. 284 - 294
[4] Patent: US2013/317059, 2013, A1. Location in patent: Paragraph 0404
[5] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0331
Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 |
View Latest Price from Methyl 2-oxo-1,2-dihydro-3-pyridinecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
10128-91-3
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | methyl 2-oxo-1,2-dihydropyridine-3-carboxylate
10128-91-3
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2019-07-06 | METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
10128-91-3
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- METHYL 2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE
10128-91-3
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- methyl 2-oxo-1,2-dihydropyridine-3-carboxylate
10128-91-3
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- METHYL 6-OXO-1,6-DIHYDRO-3-PYRIDINECARBOXYLATE
10128-91-3
- $1.00
- 98%
- Career Henan Chemical Co
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