Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate
- CAS No.
- 10350-10-4
- Chemical Name:
- Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate
- Synonyms
- AURORA KA-3793;ETHYL-4-HYDROXY-6-METHYL-2-PYRIDONE-3-CARBOXYLATE;ethyl 6-methyl-2,4-dioxo-1H-pyridine-3-carboxylate;Ethyl 4-hydroxy-6-methyl-2-pyridinone-3-carboxylate;Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridin-3-carboxylate;1,2-Dihydro-4-hydroxy-6-methyl-2-(oxo)nicotinic acid ethyl ester;ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLATE;Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate;4-Hydroxy-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid ethyl ester;1,2-Dihydro-4-hydroxy-6-methyl-2-oxo-3-pyridinecarboxylic acid ethyl ester
- CBNumber:
- CB5330652
- Molecular Formula:
- C9H11NO4
- Molecular Weight:
- 197.19
- MDL Number:
- MFCD00205625
- MOL File:
- 10350-10-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| NFPA 704 |
|
Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | KAA35010 | Ethyl 2,4-dihydroxy-6-methylnicotinate | 10350-10-4 | 100g | $250 | 2026-06-04 | Buy |
| Synthonix | E50111 | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 97% | 10350-10-4 | 5g | $25 | 2026-05-06 | Buy |
| Synthonix | E50111 | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 97% | 10350-10-4 | 10g | $30 | 2026-05-06 | Buy |
| Synthonix | E50111 | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 97% | 10350-10-4 | 25g | $50 | 2026-05-06 | Buy |
| Synthonix | E50111 | Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate 97% | 10350-10-4 | 100g | $200 | 2026-05-06 | Buy |
Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Chemical Properties,Uses,Production
Uses
Ethyl 2,4-Dihydroxy-6-methylnicotinate, is a building block used for various chemical compounds. It is used for the synthesis of analogs of Lucanthone, having antitumor and bactericidal properties.
Synthesis
626-34-6
105-53-3
10350-10-4
The general procedure for the synthesis of ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate from ethyl 3-aminocrotonate and diethyl malonate was as follows: ethyl 3-aminocrotonate (100 g, 0.7752 mol) was added to a reactor, followed by the addition of sodium ethoxide (65 g, 0.9559 mol) and anhydrous ethanol (240 g). The reaction system was slowly heated to 80-90 °C, kept at reflux, and the reaction was stirred at the same temperature for 24 hours. After completion of the reaction, the system was cooled to 50-60 °C and concentrated under reduced pressure to remove about 100 g of ethanol. The concentrated solution was slowly poured into 1000 ml of water, 10 g of alkaline activated carbon was added, stirred for 1 hour and filtered. The filtrate was cooled to below 0°C and the pH was adjusted to 2~3 with ammonium chloride, at which time a large amount of solid precipitated, and the solid was collected by filtration. The resulting solid was dried at 50 to 60°C to give white needle-like crystals of ethyl 2,4-dihydroxy-6-methyl-nicotinate in a yield of 125 g (yield = 81.85%, HPLC purity = 99.5%).
References
[1] Patent: CN106279011, 2017, A. Location in patent: Paragraph 0021; 0022
[2] Chemische Berichte, 1898, vol. 31, p. 766,769
[3] Chemische Berichte, 1898, vol. 31, p. 765
Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Preparation Products And Raw materials
Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd | 18901358086 | pharma_reese@126.com | China | 48 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
View Lastest Price from Ethyl 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-08 | ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
10350-10-4
|
$1.00 | 1IU | 99.0% | 100kg | Career Henan Chemical Co |
-
- ETHYL 4-HYDROXY-6-METHYL-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXYLATE
10350-10-4
- $1.00
- 99.0%
- Career Henan Chemical Co
