2-Hydroxynicotinic acid
- CAS No.
- 609-71-2
- Chemical Name:
- 2-Hydroxynicotinic acid
- Synonyms
- Hydroxynicotinic acid;2-Oxo-1,2-dihydropyridine-3-carboxylic acid;NSC 226152;2-Hydroxy acid;2 - hydroxy niacin;2-Hydroxynicotinic;TIMTEC-BB SBB004180;3-Carboxy-2-pyridone;2-Hydroxynicotinic a;2-HYDROXYNICOTINIC ACID
- CBNumber:
- CB0763471
- Molecular Formula:
- C6H5NO3
- Molecular Weight:
- 139.11
- MDL Number:
- MFCD00010100
- MOL File:
- 609-71-2.mol
- MSDS File:
- SDS
| Melting point | 258-261 °C(lit.) |
|---|---|
| Boiling point | 255.04°C (rough estimate) |
| Density | 1.4429 (rough estimate) |
| refractive index | 1.5423 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | 0.1 M NaOH: 0.1 g/mL, clear |
| pka | 2.40±0.20(Predicted) |
| form | Powder |
| color | White to light yellow |
| BRN | 119028 |
| InChI | InChI=1S/C6H5NO3/c8-5-4(6(9)10)2-1-3-7-5/h1-3H,(H,7,8)(H,9,10) |
| InChIKey | UEYQJQVBUVAELZ-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC=C1C(O)=O |
| CAS DataBase Reference | 609-71-2(CAS DataBase Reference) |
| FDA UNII | TMQ68Q9BA3 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Hydroxynicotinic acid price More Price(72)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 251054 | 2-Hydroxypyridine-3-carboxylic acid 98% | 609-71-2 | 25g | $82.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | 251054 | 2-Hydroxypyridine-3-carboxylic acid 98% | 609-71-2 | 100g | $137 | 2026-04-30 | Buy |
| TCI Chemical | H0795 | 2-Hydroxynicotinic Acid >98.0%(GC)(T) | 609-71-2 | 25g | $100 | 2026-04-30 | Buy |
| TRC | TRC-H948725-1G | 2-Hydroxy Nicotinic Acid | 609-71-2 | 1g | $116 | 2026-06-03 | Buy |
| TRC | TRC-H948725-10G | 2-Hydroxy Nicotinic Acid | 609-71-2 | 10g | $1014 | 2026-06-03 | Buy |
2-Hydroxynicotinic acid Chemical Properties,Uses,Production
Synthesis
At 0°C, 2 M i-PrMgCl THF (2.2 ml, 1.0 equivalent) solution was added over 5 minutes to an anhydrous THF (20 ml) solution of 3-bromo-2-hydroxypyridine (0.76 g, 4.4 mmol, 1.0 equivalent). The clear solution was stirred at this temperature for another 5 minutes, and a 2.5 M hexane solution of n-butyllithium (3.5 ml, 2.0 equivalent) was added dropwise over 5 minutes while maintaining the temperature below -20°C. The resulting mixture was stirred at this temperature for 0.5 hours, and dried CO2 (0.20 g, 1.0 equivalent) was added to the -20°C system. The resulting mixture was heated to -20°C over 0.5 hours and quenched with water (6 ml). After stirring the mixture below -20°C for 10 minutes, the phases were separated, and the aqueous phase was extracted once more with ethyl acetate. The resulting suspension was brought to room temperature and passed through a 0.5 × 1 cm silica gel sieve, eluted with 10 ml of ethyl acetate. The filtrate was concentrated, and the residue was purified by rapid silica gel chromatography (eluent: petroleum ether/ethyl acetate = 10:1) to give the product 2-hydroxynicotinic acid, a grayish-white solid, 0.48 g (yield: 79%), mp: 255–257°C.
Chemical Properties
White to light yellow powder
Uses
2-Hydroxynicotinic acid is used in chemical synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals agrochemicals and dyestuff fields.
Definition
ChEBI: 2-Hydroxynicotinic acid is a member of pyridines and an aromatic carboxylic acid. It is a derivative of nicotinic acid, was found to exist in four polymorphs. It is used as a growth factor in Erwinia amylovora growth (pear and apple blossoms).
2-Hydroxynicotinic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangyin Jufeng Biotechnology Co., Ltd | 0519-89891966 13906113265 | 986329407@qq.com | China | 55 | 58 |
| Jinan Hongwan Biotechnology Co., Ltd. | 58767175 13220585822 | 1256200339@qq.com | China | 62 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Lastest Price from 2-Hydroxynicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2-Hydroxynicotinic acid
609-71-2
|
1KG | 98% | 5000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | 2-Hydroxynicotinic acid
609-71-2
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2-Hydroxynicotinic acid
609-71-2
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Hydroxynicotinic acid
609-71-2
- $0.00
- 98%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Hydroxynicotinic acid
609-71-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Hydroxynicotinic acid
609-71-2
- 98%
- Shaanxi Dideu New Materials Co. Ltd
