H-TRP-GLU-OH
- CAS No.
- 36099-95-3
- Chemical Name:
- H-TRP-GLU-OH
- Synonyms
- WE;G3335;TRP-GLU;L-TRP-GLU;H-TRP-GLU-OH;TRP-GLU CRYSTALLINE;PPARγ Antagonist III,G3335;PPARγ Antagonist III, G3335;L-TRYPTOPHYL-L-GLUTAMIC ACID;L-Glutamic acid, L-tryptophyl-
- CBNumber:
- CB7745599
- Molecular Formula:
- C16H19N3O5
- Molecular Weight:
- 333.34
- MDL Number:
- MFCD00037964
- MOL File:
- 36099-95-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >163°C(dec.) |
|---|---|
| Boiling point | 720.7±60.0 °C(Predicted) |
| Density | 1.428±0.06 g/cm3(Predicted) |
| storage temp. | -15°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| pka | 3.02±0.10(Predicted) |
| form | White solid |
| color | white to off-white |
| Water Solubility | water: 30mg/mL |
| Sensitive | Light Sensitive |
| InChI | 1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1 |
| InChIKey | PWIQCLSQVQBOQV-AAEUAGOBSA-N |
| SMILES | [nH]1c2c(c(c1)C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cccc2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
H-TRP-GLU-OH price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 516566 | PPARγ Antagonist III, G3335 | 36099-95-3 | 50mg | $149 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1449 | G3335 ≥98% (HPLC) | 36099-95-3 | 50mg | $103 | 2025-07-31 | Buy |
| Cayman Chemical | 17593 | G3335 ≥98% | 36099-95-3 | 10mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17593 | G3335 ≥98% | 36099-95-3 | 25mg | $73 | 2026-04-30 | Buy |
| Cayman Chemical | 17593 | G3335 ≥98% | 36099-95-3 | 50mg | $107 | 2026-04-30 | Buy |
H-TRP-GLU-OH Chemical Properties,Uses,Production
Uses
A cell-permeable dipeptide that acts as a selective and reversible peroxisome proliferator-activated receptor antagonist
Definition
ChEBI: Trp-Glu is a dipeptide formed from L-tryptophan and L-glutamic acid residues. It has a role as a metabolite.
Biological Activity
kd = 8.34 μmg3335 is a pparγ antagonist.the peroxisome proliferator-activated receptor gamma (ppargamma) is a key therapeutic drug target for several conditions, such as inflammation, diabetes, hypertension, dyslipidemia, and cancer.
in vitro
biacore 3000 study based on the surface plasmon resonance technique found that g3335 exhibited a highly specific binding affinity against ppargamma and was able to block rosiglitazone, a potent ppargamma agonist, in the stimulation of the interaction between the ppargamma ligand-binding domain (lbd) and rxralpha-lbd. moreover, the yeast two-hybrid assays indicated that g3335 had strong antagonistic activity in perturbing rosiglitazone in the promotion of the ppargamma-lbd-cbp interaction. in addition, g3335 could competitively bind to ppargamma against 0.1 microm rosiglitazone to repress reporter-gene expression [1].
in vivo
in a previous study, the effect of rosiglitazone was examined on spinal cord injury (sci) in rats. the animals were randomly divided into vehicle group, rosiglitazone treated group, and g3335 treated group. locomotor function recovery was evaluated. results showed that compared with the vehicle groups, the rosiglitazone could significantly ameliorate locomotor recovery, reduce nf-κb expression, and increase the proliferation of endogenous npcs. in addition, when the ppar-γ antagonist g3335 was applied, such effects were abolished [2].
IC 50
PPARγ: 8 μM (Kd)
References
[1] ye, f. ,zhang, z.s.,luo, h.b., et al. the dipeptide h-trp-glu-oh shows highly antagonistic activity against pparγ: bioassay with molecular modeling simulation. chembiochem 7, 74-82 (2006).
[2] meng, q. q.,liang, x.j.,wang, p., et al. rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. neuroscience letters 503, 191-195 (2011).
H-TRP-GLU-OH Preparation Products And Raw materials
Raw materials
Preparation Products
H-TRP-GLU-OH Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Sichuan Ampebiochem Co., Ltd. | 028-65294243 18682730901 | sales@ampebiochem.com | China | 1000 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
