MELEAGRIN
- CAS No.
- 71751-77-4
- Chemical Name:
- MELEAGRIN
- Synonyms
- Meleagrine;MELEAGRIN;6-O-Methyloxaline, Meleagrine;(7AR,12aS,E)-3-((1H-imidazol-5-yl)methylene)-6-hydroxy-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydroimidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(1H,3H)-dione;[3E,7aR,12aS,(-)]-7a-(1,1-Dimethyl-2-propenyl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazole-4-ylmethylene)-12-methoxy-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2(3H),5-dione;1H,5H-Imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, 7a-(1,1-dimethyl-2-propen-1-yl)-7a,12-dihydro-6-hydroxy-3-(1H-imidazol-5-ylmethylene)-12-methoxy-, (3E,7aR,12aS)-;(1S,9R,14E)-11-hydroxy-14-[(1H-imidazol-5-yl)methylidene]-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,?]hexadeca-3(8),4,6,10-tetraene-12,15-dione
- CBNumber:
- CB7816480
- Molecular Formula:
- C23H23N5O4
- Molecular Weight:
- 433.46
- MDL Number:
- MFCD08702703
- MOL File:
- 71751-77-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >165oC |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml) |
| form | Yellow oil. |
| color | Tan |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| FDA UNII | 5780K492K3 |
MELEAGRIN price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17850 | Meleagrin ≥98% | 71751-77-4 | 1mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 17850 | Meleagrin ≥98% | 71751-77-4 | 5mg | $629 | 2026-04-30 | Buy |
| Usbiological | 454312 | Meleagrin | 71751-77-4 | 1mg | $403 | 2026-06-03 | Buy |
| Usbiological | 454312 | Meleagrin | 71751-77-4 | 5mg | $941 | 2026-06-03 | Buy |
| TRC | TRC-M215335-5MG | Meleagrin | 71751-77-4 | 5mg | $726 | 2026-06-03 | Buy |
MELEAGRIN Chemical Properties, Uses, Production
Description
Meleagrin (71751-77-4) is a novel alkaloid biosynthesized via the roquefortine branched biosynthetic pathway.1,2 Displays excellent ATP-competitive c-MET inhibition, inhibiting the growth, migration and invasion of numerous breast cancer cell lines.3 Also has been shown to inhibit the bacterial enoyl-acyl carrier protein reductase (Fabl) with IC50s in the 33-40 mM range.4
Uses
Meleagrin is an alkaloid with antitumor and antibiotic activity, isolated from a number of species of Penicillium. Meleagrin is a common taxonomic marker for fungal contamination of foodstuffs. Despite its wide detection in the environment, the mode of action and bioprofile has not been extensively reported. Note that meleagrin, the fungal metabolite, should not be confused with the low molecular weight protein, also meleagrin.
Uses
Meleagrin is a is an antibiotic derived from the deep ocean and is identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase. (Fabl). Inhibits the growth of S. aureus, E.coli, and S.pneumoniae
Definition
ChEBI: An indole alkaloid with a heterotetracyclic skeleton isolated from Penicillium oxalicum.
in vitro
it was found that consistent with their selective inhibition of staphylococcus aureus fabi, meleagrin and its more active derivatives could directly bind to s. aureus fabi that was measured in a fluorescence quenching assay, inhibit intracellular fatty acid biosynthesis and growth of s. aureus, and increase the minimum inhibitory concentration (mic) for fabi-overexpressing s. aureus. the compounds that were not effective against the fabk isoform, however, were able to inhibit the growth of streptococcus pneumoniae containing only the fabk isoform. in addition, no resistant mutant to these compounds was obtained. notely, fabk-overexpressing escherichia coli was found to be not resistant to these compounds, but was resistant to triclosan [1]. another study found that meleagrin was able to inhibit the growth of the human breast cancer cell lines, while similar treatment doses had no effect on the growth and viability of the non-tumorigenic human mammary epithelial cells mcf10a. meleagrin also displayed good atp competitive c-met inhibitory activity in z-lyte assay [2].
storage
+4°C
References
[1] MARCO I RIES. Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.[J]. The Journal of Biological Chemistry, 2013: 37289-37295. DOI:10.1074/jbc.m113.512665
[2] SEAN A. NEWMISTER. OxaD: A Versatile Indolic Nitrone Synthase from the Marine-Derived Fungus Penicillium oxalicum F30[J]. Journal of the American Chemical Society, 2016, 138 35: 11176-11184. DOI:10.1021/jacs.6b04915
[3] MOHAMED S. MADY . The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion[J]. Bioorganic & Medicinal Chemistry, 2016, 24 2: Pages 113-122. DOI:10.1016/j.bmc.2015.11.038
[4] CHANG JI ZHENG. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action.[J]. PLoS ONE, 2013: e78922. DOI:10.1371/journal.pone.0078922
MELEAGRIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Aikon International Limited | 025-58851090 13913916777 | sales01@aikonchem.com | China | 15947 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
