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ChemicalBook >> CAS DataBase List >>(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE Structure
(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE structure
CAS No.
150375-75-0
Chemical Name:
(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE
Synonyms
Relcovaptan;SR 49059;reclovaptan;Relcovaptan (SR-49059);INDOL-2-YLCARBONYL)-L-PROLINAMIDE;(S)-1-((2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-((3,4-dimethoxyphenyl)sulfonyl)-3-hydroxyindoline-2-carbonyl)pyrrolidine-2-carboxamide;(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE;2-Pyrrolidinecarboxamide, 1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-, (2S)-
CBNumber:
CB7842557
Molecular Formula:
C28H27Cl2N3O7S
Molecular Weight:
620.5
MDL Number:
MFCD00922133
MOL File:
150375-75-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
SR 49059 ≥97% (HPLC) S5701 5mg $239
SR 49059 ≥97% (HPLC) S5701 25mg $895
SR 49059 ≥98% 17972 1mg $54
SR 49059 ≥98% 17972 5mg $185
SR 49059 ≥98% 17972 10mg $341
Request For Quotation

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE Properties

Melting point 158-160oC
Boiling point 868.0±75.0 °C(Predicted)
Density 1.499±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥10mg/mL
form powder
pka 10.95±0.40(Predicted)
color white to off-white
optical activity [α]/D -180 to -190°, c = 0.3 in chloroform-d
Stability Hygroscopic
InChIKey CEBYCSRFKCEUSW-NAYZPBBASA-N
SMILES COc1ccc(cc1OC)S(=O)(=O)N2[C@@H](C(=O)N3CCC[C@H]3C(N)=O)[C@@](O)(c4ccccc4Cl)c5cc(Cl)ccc25
NCI Dictionary of Cancer Terms SR49059
FDA UNII C1GL8G6G0O
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317
Precautionary statements  P280-P305+P351+P338
WGK Germany  nwg
Storage Class 11 - Combustible Solids

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S5701 SR 49059 ≥97% (HPLC) 150375-75-0 5mg $239 2026-04-30 Buy
Sigma-Aldrich S5701 SR 49059 ≥97% (HPLC) 150375-75-0 25mg $895 2026-04-30 Buy
Cayman Chemical 17972 SR 49059 ≥98% 150375-75-0 1mg $54 2026-04-30 Buy
Cayman Chemical 17972 SR 49059 ≥98% 150375-75-0 5mg $185 2026-04-30 Buy
Cayman Chemical 17972 SR 49059 ≥98% 150375-75-0 10mg $341 2026-04-30 Buy
Product number Packaging Price Buy
S5701 5mg $239 Buy
S5701 25mg $895 Buy
17972 1mg $54 Buy
17972 5mg $185 Buy
17972 10mg $341 Buy

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE Chemical Properties,Uses,Production

Uses

Relcovaptan is a selective vasopressin-1a receptor antagonist that prevents cellular swelling and provides treatment for post-traumatic brain edema.

Definition

ChEBI: (2S)-1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxyphenyl)sulfonyl-3-hydroxy-2H-indol-2-yl]-oxomethyl]-2-pyrrolidinecarboxamide is a proline derivative.

Biological Activity

Potent and selective non-peptide vasopressin V 1A receptor antagonist; devoid of agonist activity. Displays high affinity and efficacy at both rat (K i = 1.6 nM) and human (K i = 1.1-6.3 nM) V 1A receptors. Potently antagonizes arginine vasopressin-induced effects in vitro (IC 50 = 3.7 nM for inhibition of human platelet aggregation) and is orally active in vivo .

Biochem/physiol Actions

SR 49059 is a potent and selective Arginine Vasopressin (AVP) V1a-receptor antagonist. AVP is a hormone that plays an important part in circulatory and water homoeostasis and is important in renal hemodynamic alterations, water retention, and cardiac remodeling in congestive heart failure (CHF). There are three AVP receptor subtypes V1a, V1b, and V2. All belong to the large rhodopsin-like G-protein-coupled receptor family. V(1a) antagonists improve water balance and cardiac hypertrophy in CHF and might be beneficial for the treatment of water retention and cardiac remodeling in CHF. SR 49059 has also shown initial positive results in the treatment of Raynaud′s disease, dysmenorrhoea, and tocolysis.

storage

Store at +4°C

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE Suppliers

Global( 62)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Aladdin Scientific 		tp@aladdinsci.com United States 50108 58
TargetMol Chemicals Inc. 		13564774135 marketing@targetmol.com United States 19950 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44924 58
Shanghai Universal Biotech Co.,Ltd 15921930842 15921930842 yh-wang@univ-bio.com China 25030 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Sigma-Aldrich 80
Shanghai EFE Biological Technology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Universal Biotech Co.,Ltd 58

View Lastest Price from (2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SR 49059 pictures 2026-07-15 SR 49059
150375-75-0
 $1600.00 10g TargetMol Chemicals Inc.
  • SR 49059 pictures
  • SR 49059
    150375-75-0
  • $1600.00
  • TargetMol Chemicals Inc.

150375-75-0((2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE)Related Search:

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2-AMINO-1-(3-CHLORO-PHENYL)-ETHANOL HCL (R)-2-AMINO-1-(3-CHLOROPHENYL) ETHANOL HYDROCHLORIDE Benzenemethanol, a-(aminomethyl)-2-chloro-, hydrochloride, (S)-

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(2S)-1-[[(2R,3S)-5-CHLORO-3-(2-CHLOROPHENYL)-1-[(3,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-HYDROXY-1H-INDOL-2-YL]CARBONYL]-2-PYRROLIDINECARBOXAMIDE INDOL-2-YLCARBONYL)-L-PROLINAMIDE reclovaptan SR 49059 Relcovaptan (SR-49059) 2-Pyrrolidinecarboxamide, 1-[[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-hydroxy-1H-indol-2-yl]carbonyl]-, (2S)- (S)-1-((2R,3S)-5-Chloro-3-(2-chlorophenyl)-1-((3,4-dimethoxyphenyl)sulfonyl)-3-hydroxyindoline-2-carbonyl)pyrrolidine-2-carboxamide Relcovaptan 150375-75-0 C28H27Cl2N3O7S