ChemicalBook >> CAS DataBase List >>1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine structure

CAS No.: 105628-72-6

Chemical Name:: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine

Synonyms: Ha 1100;Fasudil Impurity L;Fasudil Impurity 5;1-[(1,2-DIHYDRO-1-OX;HA 1100 HYDROCHLORIDE;HA-1100;HA 1100;HA1100;Hydroxyfasudil, 10 mM in DMSO;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one

CBNumber:: CB7847446

Molecular Formula:: C14H17N3O3S

Molecular Weight:: 307.37

MDL Number:: MFCD01752417

MOL File:: 105628-72-6.mol

MSDS File:: SDS

Last updated:2026-09-12 18:55:07

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1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Properties

storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO
form	Solid
color	White to off-white
InChI	InChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChIKey	ZAVGJDAFCZAWSZ-UHFFFAOYSA-N
SMILES	C1(=O)C2=C(C(S(N3CCCNCC3)(=O)=O)=CC=C2)C=CN1
EWG's Food Scores	1
FDA UNII	EYH4AU7P63

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Toxicity	mouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	40814	Hydroxyfasudil ≥98%	105628-72-6	5mg	$65	2026-04-30	Buy
Cayman Chemical	40814	Hydroxyfasudil ≥98%	105628-72-6	10mg	$110	2026-04-30	Buy
Cayman Chemical	40814	Hydroxyfasudil ≥98%	105628-72-6	25mg	$228	2026-04-30	Buy
Cayman Chemical	40814	Hydroxyfasudil ≥98%	105628-72-6	50mg	$325	2026-04-30	Buy
ApexBio Technology	A3478	Hydroxyfasudil	105628-72-6	10mg	$116	2026-05-06	Buy

Product number	Packaging	Price	Buy
40814	5mg	$65	Buy
40814	10mg	$110	Buy
40814	25mg	$228	Buy
40814	50mg	$325	Buy
A3478	10mg	$116	Buy

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Chemical Properties, Uses, Production

Biological Activity

Cell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Preparation Products And Raw materials

Raw materials

Preparation Products

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Suppliers

Global Suppliers ( 100)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Ran enzyme Biotechnology Co., Ltd.	0512-0512-62793604 18015430729	116667374@qq.com	China	132	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58

Supplier	Advantage
Suzhou Ran enzyme Biotechnology Co., Ltd.	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
VDM Biochemicals	64
BOC Sciences	65
Haoyuan Chemexpress Co., Ltd.	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
MedChemexpress LLC	58
AdooQ BioScience, LLC	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58

View Latest Price from 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-09-02	1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE 105628-72-6	$1.00	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE
105628-72-6
$1.00
98%
Career Henan Chemical Co

1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Spectrum

1-[(1,2-DIHYDRO-1-OXO-5-ISOQUINOLINYL)SULFONYL]HEXAHYDRO-1H-1,4-DIAZEPINE(105628-72-6)¹HNMR

105628-72-6 (1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine) Related Search:

5-Quinolinesulfonic acid, 2-methyl- Fasudil Impurity 6 Fasudil Impurity 13 Fasudil Pyridine N-Oxide TFA Salt Isoquinoline

Fasudil Impurity 9 Fasudil Impurity 34 Fasudil iMpurity Fasudil Impurity 7 1-[(1-Chloro-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine

Fasudil Impurity 8 1-Chloro-5-isoquinolinesulfonic Acid Fasudil Impurity 6 1,4-ditosyl-1,4-diazepane Fasudil diMer

Fasudil N-hydroxy iMpurity Hydroxyfasudil monohydrochloride N-(3-Hydroxypropyl)ethylenediamine

1of4

5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one HYDROXYFASUDIL;HA-1100;HA 1100;HA1100 1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)- Ha 1100 Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol Fasudil Impurity L HA 1100 HYDROCHLORIDE 1-[(1,2-DIHYDRO-1-OX 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinolin-1(2H)-one Fasudil impurity 12/5-(1,4-diazepan-1-ylsulfonyl)-2H-isoquinolin-1-one hydrochloride HA-1100;HA 1100;HA1100 1(2H)-Isoquinolinone, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]- 5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1(8aH)-one HA1100,ROCK,Rho-kinase,inhibit,Rho-associated kinase,Inhibitor,ROK,Hydroxyfasudil,HA 1100,Rho-associated protein kinase Fasudil Impurity 5 Hydroxyfasudil, 10 mM in DMSO 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine 105628-72-6 C14H17N3O3S Angiogenesis and Metastasis Intracellular signaling