Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- CAS No.
- 862599-47-1
- Chemical Name:
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate
- Synonyms
- Ethyl 2-chlorooxazole-5-carboxylate;2-Chloro-5-(ethoxycarbonyl)-1,3-oxazole;Ethyl 2-chloro-1,3-oxazole-5-carboxylate;Ethyl 2-chloro-1,3-oxazole-5-carboxylate 98%;5-Oxazolecarboxylic acid, 2-chloro-, ethyl ester
- CBNumber:
- CB7958263
- Molecular Formula:
- C6H6ClNO3
- Molecular Weight:
- 175.57
- MDL Number:
- MFCD09475866
- MOL File:
- 862599-47-1.mol
- MSDS File:
- SDS
| Boiling point | 254.1±32.0 °C(Predicted) |
|---|---|
| Density | 1.332±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | -2+-.0.10(Predicted) |
| form | liquid |
| color | Orange |
| InChI | InChI=1S/C6H6ClNO3/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3 |
| InChIKey | ZFLDTEIDAGWEEI-UHFFFAOYSA-N |
| SMILES | O1C(C(OCC)=O)=CN=C1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| Hazard Codes | Xi |
| Hazard Note | Irritant/Keep Cold |
| HS Code | 2934999090 |
Ethyl 2-chloro-1,3-oxazole-5-carboxylate price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR11484 | Ethyl 2-chloro-1,3-oxazole-5-carboxylate >98% | 862599-47-1 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR11484 | Ethyl 2-chloro-1,3-oxazole-5-carboxylate >98% | 862599-47-1 | 250mg | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR11484 | Ethyl 2-chloro-1,3-oxazole-5-carboxylate >98% | 862599-47-1 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR11484 | Ethyl 2-chloro-1,3-oxazole-5-carboxylate >98% | 862599-47-1 | 5g | $175 | 2026-06-04 | Buy |
| Apolloscientific | OR11484 | Ethyl 2-chloro-1,3-oxazole-5-carboxylate >98% | 862599-47-1 | 25g | $825 | 2026-06-04 | Buy |
Ethyl 2-chloro-1,3-oxazole-5-carboxylate Chemical Properties, Uses, Production
Synthesis
118994-89-1
862599-47-1
General procedure for the synthesis of ethyl 2-chlorooxazole-5-carboxylate from ethyl oxazole-5-carboxylate: to a solution of ethyl oxazole-5-carboxylate (15.0 g, 106 mmol) in tetrahydrofuran (THF, 150 mL) was added slowly and dropwise to a solution of lithium hexamethyldisilanamide (LiHMDS, 178 mL, 170 mmol) at -60 °C. The reaction mixture was stirred continuously at -50 °C for 1 hour. Subsequently, hexachloroethane (37.8 g, 160 mmol) was added to the reaction system. The reaction mixture was warmed to room temperature and stirred for 12 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) solution (50 mL) and subsequently extracted with ethyl acetate (EtOAc, 50 mL). The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by column chromatography to afford the target product ethyl 2-chlorooxazole-5-carboxylate (10 g, 56% yield) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 7.71 (s, 1H), 3.39 (q, J=7.2 Hz, 2H), 1.38 (t, J=7.2 Hz, 3H).
References
[1] Organic Letters, 2005, vol. 7, # 15, p. 3351 - 3354
[2] Patent: WO2015/116663, 2015, A1. Location in patent: Paragraph 0116
Ethyl 2-chloro-1,3-oxazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dtchem Laboratories,（Gan Su）Co.,Ltd. | 18993961550 18993966060 | sales@techbiochem.com | China | 773 | 61 |
| Beijing InnoChem Science & Technology Co., Ltd. | 15652467323 | sales@inno-chem.com.cn | China | 8390 | 58 |
| Shaoyuan Technology (Shanghai) Co., Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9985 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from Ethyl 2-chloro-1,3-oxazole-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-04-22 | ethyl 2-chlorooxazole-5-carboxylate
862599-47-1
|
98%min | 100kgs/month | Shanghai Rlavie Technology Co ltd | |||
 |
2019-12-23 | Ethyl 2-chloro-1,3-oxazole-5-carboxylate
862599-47-1
|
$1.00 | 100g | 99% | Career Henan Chemical Co |
-
- ethyl 2-chlorooxazole-5-carboxylate
862599-47-1
- $0.00
- 98%min
- Shanghai Rlavie Technology Co ltd
-
- Ethyl 2-chloro-1,3-oxazole-5-carboxylate
862599-47-1
- $1.00
- 99%
- Career Henan Chemical Co
