ChemicalBook >> CAS DataBase List >>Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-
![Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Structure](CAS/20210305/GIF/1415321-64-0.gif)
- CAS No.
- 1415321-64-0
- Chemical Name:
- Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-
- Synonyms
- SR10221;(S)-2-(5-((5-(((S)-1-(4-(tert-Butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-2-chlorophenoxy)propanoic acid;Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-
- CBNumber:
- CB79740195
- Molecular Formula:
- C33H37ClN2O4
- Molecular Weight:
- 561.11
- MDL Number:
- MOL File:
- 1415321-64-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 03:29:51
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Properties
| Boiling point | 773.7±60.0 °C(Predicted) |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| solubility |
DMSO: Soluble: =10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml |
| pka | 3.11±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18292 | SR10221 ≥98% | 1415321-64-0 | 1mg | $43 | 2026-04-30 | Buy |
| Cayman Chemical | 18292 | SR10221 ≥98% | 1415321-64-0 | 5mg | $172 | 2026-04-30 | Buy |
| Cayman Chemical | 18292 | SR10221 ≥98% | 1415321-64-0 | 10mg | $258 | 2026-04-30 | Buy |
| Cayman Chemical | 18292 | SR10221 ≥98% | 1415321-64-0 | 25mg | $483 | 2026-04-30 | Buy |
| ChemScene | CS-1060569 | SR10221 98.96% | 1415321-64-0 | 5mg | $162 | 2026-06-04 | Buy |
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Chemical Properties, Uses, Production
Description
SR10221 is a PPARγ inverse-agonist. SR10221 represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines.
Uses
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines[1].
References
[1] Sean Irwin, et al. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. J Biol Chem. 2022 Nov;298(11):102539. DOI:10.1016/j.jbc.2022.102539
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Preparation Products And Raw materials
Raw materials
Preparation Products
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- Suppliers
Global Suppliers ( 15)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2444 | 58 |
| Hangzhou Taorui Biotechnology Co., Ltd | QQ1259737804 15268198094 | sales@torreybio.com | China | 4129 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Beijing Keyi Tongda Technology Development Co., Ltd | 17743531240 | kytd20@sina.com | China | 1512 | 58 |
| Xi'an Lechun Chemical Co., Ltd | 029-15596886083 15596886083 | 739383595@qq.com | China | 4142 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Zibo Binlai Pharmaceutical Technology Co., Ltd. | 15963310191 | sales@binlaichem.com | China | 282 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
1415321-64-0 (Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-) Related Search:
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Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)-
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SR10221
(S)-2-(5-((5-(((S)-1-(4-(tert-Butyl)phenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-2-chlorophenoxy)propanoic acid
1415321-64-0
