ChemicalBook >> CAS DataBase List >>INDOMETHACIN SODIUM SALT TRIHYDRATE
INDOMETHACIN SODIUM SALT TRIHYDRATE
- CAS No.
- 74252-25-8
- Chemical Name:
- INDOMETHACIN SODIUM SALT TRIHYDRATE
- Synonyms
- Indometacin Sodium;INDOMETACIN FARNESIL;Sodium salt trihydrate;Indomethacin sodium hydrate;Indomethacin sodium trihydrate;Indomethacin sodium salt 3-hydrate;INDOMETHACIN SODIUM SALT TRIHYDRATE;Indomethacin (Indometacin) sodium hydrateis;sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
- CBNumber:
- CB81012013
- Molecular Formula:
- C34H40ClNO4
- Molecular Weight:
- 562.146
- MDL Number:
- MOL File:
- 74252-25-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-05-28 03:46:45
| storage temp. | 4°C, protect from light, stored under nitrogen |
|---|---|
| solubility | DMSO: 5 mg/mL (11.53 mM) |
| form | Solid |
| color | Light yellow to yellow |
| Water Solubility | Water: 33.33 mg/mL (76.83 mM) |
| InChIKey | CFIGYZZVJNJVDQ-LMJOQDENSA-N |
| SMILES | C12C=CC(OC)=CC=1C(=C(C)N2C(=O)C1C=CC(Cl)=CC=1)CC(=O)OC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/C |
| FDA UNII | 0IMX38M2GG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H370 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P307+P311-P321-P405-P501 |
INDOMETHACIN SODIUM SALT TRIHYDRATE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0089425 | Indomethacin sodium hydrate 99.85% | 74252-25-8 | 500mg | $54 | 2026-06-04 | Buy |
| ChemScene | CS-0089425 | Indomethacin sodium hydrate 99.85% | 74252-25-8 | 1g | $65 | 2026-06-04 | Buy |
| ApexBio Technology | C6491 | Indomethacin sodium trihydrate | 74252-25-8 | 500mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | C6491 | Indomethacin sodium trihydrate | 74252-25-8 | 1g | $60 | 2026-05-06 | Buy |
| aablocks | AA00FFBU | 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt, hydrate (1:1:3) ≥96% | 74252-25-8 | 1g | $23 | 2026-05-28 | Buy |
INDOMETHACIN SODIUM SALT TRIHYDRATE Chemical Properties, Uses, Production
Uses
Anti-inflammatory.
brand name
Indocin (Ovation).
Hazard
A poison by ingestion.
in vivo
Indomethacin sodium hydrate can be used to create gastric ulcer models. After oral administration, the drug is absorbed rapidly and completely, although there are interindividual and intraindividual variations. The plasma peak concentration of 2-3 μg/mL is typically reached within 1-2 hours. However, coadministration with food reduces and delays the peak concentration without affecting the total absorption. At therapeutic concentrations, 90% of Indomethacin is bound to albumin in the plasma[4].
Induction of gastric ulceration[5][6]
Background
Indomethacin can cause gastric ulceration by various mechanisms, including injury through inhibition of prostaglandin (PG) synthesis, reduction in local blood flow, regional irritation, and inhibition of tissue regeneration.
Specific Modeling Methods
Rat: albino Sprague-Dawley male adult (period: 2 weeks)
Administration: 100 mg/kg p.o. single dose
Administration: 100 mg/kg p.o. single dose
Note
(1) All animals fasted 24 h before drug administration.
(2) Indomethacin were dissolved in saline with 5% NaOH.
(2) Indomethacin were dissolved in saline with 5% NaOH.
Modeling Indicators
Gastric tissue macroscopic alterations: Showed prominent mucosal folds and severe erosion, pronounced ulceration and bleeding foci in the gastric mucosa.
Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
Molecular changes: Showed intense Tnf-α expression.
Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.
Histopathological changes: Showed severe erosion of the mucosa, reaching down to the lamina muscularis; observed hemorrhagic infiltration, edema in the submucosa, and severe hyperemia of the vessels.
Molecular changes: Showed intense Tnf-α expression.
Biochemical changes: Increased MDA, TOS levels, reduced TAS levels, CAT and GPx activities and GSH levels.
Correlated Product(s): Indomethacin sodium hydrate (HY-14397A)
Opposite Product(s): Carnosic acid (HY-N0644)
| Animal Model: | Male Sprague-Dawley rats[1] |
| Dosage: | 0.01-10 mg/kg |
| Administration: | Oral administration; for 3 hours |
| Result: | Inhibited the carrageenan-induced rat paw oedema (ED50=2.0mg/kg) and hyperalgesia (ED50=1.5mg/kg) in a dose-dependent manner. |
| Animal Model: | Male C57BL/6J mice[2] |
| Dosage: | 10 mg/mL |
| Administration: | Oral administration; daily, for 29 days |
| Result: | Delayed the onset of tumor growth and the initial growth rate of the footpad tumors. |
INDOMETHACIN SODIUM SALT TRIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 106)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi ravel Biotechnology Co.,Ltd | 400-880-2824 18107960669 | 79046690@qq.com | China | 1114 | 58 |
| Jinan Jinchi Pharmaceutical Technology Co., LTD | 15168890063 18888326116 | 76337143@qq.com | China | 64 | 58 |
| Hubei Yuanmeng Biotechnology Co., Ltd | 027-68897569 18120462897 | fiona@yuanmengbio.com | China | 4653 | 58 |
| Hubei Yuanmeng Biological Technology Co., Ltd. | 027-68897569 18120462897 | 2225602544@qq.com | China | 4337 | 58 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6741 | 52 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Chizhou Kailong Import and Export Trade Co., Ltd. | xg01_gj@163.com | China | 9413 | 50 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shenzhen Simeiquan Biotechnology Co. Ltd | 18126413629 0755-23311925 2355327053 | abel@ycgmp.com | China | 5101 | 58 |
| Hubei widely chemical technology Co., Ltd. | 027-83991130 18627774460 | 1718093273@QQ.COM | China | 1617 | 58 |
View Latest Price from INDOMETHACIN SODIUM SALT TRIHYDRATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-15 | INDOMETHACIN SODIUM SALT TRIHYDRATE
74252-25-8
|
1kg | 99.0% | 1tons | Henan Suikang Pharmaceutical Co.,Ltd. | ||
 |
2021-11-23 | Indometacin sodium
74252-25-8
|
$10.00 | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- INDOMETHACIN SODIUM SALT TRIHYDRATE
74252-25-8
- 99.0%
- Henan Suikang Pharmaceutical Co.,Ltd.
-
- Indometacin sodium
74252-25-8
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
74252-25-8 (INDOMETHACIN SODIUM SALT TRIHYDRATE) Related Search:
INDOMETHACIN SODIUM SALT TRIHYDRATE
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodi um salt, trihydrate
1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-Methoxy-2-Methyl-, sodiuM salt, hydrate (1:1:3)
Sodium salt trihydrate
sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate
Indomethacin sodium hydrate
Indomethacin sodium salt 3-hydrate
Indomethacin sodium trihydrate
Indomethacin (Indometacin) sodium hydrateis
INDOMETACIN FARNESIL
Indometacin Sodium
74252-25-8
C19H21ClNNaO7
