ChemicalBook >> CAS DataBase List >>4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) structure

CAS No.: 65996-58-9

Chemical Name:: 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)

Synonyms: NSC 344522;9-deazaguanine;2-amino-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one;2-amino-1H-pyrrolo[3,2-d]pyrimidin-4(5H)-one;2-amino-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;2-Amino-3,5-dihydropyrrolo[3,2-D]pyrimidine-4-one;2-AMINO-3,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDIN-4-ONE;4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-1,5-dihydro-;2-amino-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one;2-Amino-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

CBNumber:: CB81081820

Molecular Formula:: C6H6N4O

Molecular Weight:: 150.14

MDL Number:: MFCD09540493

MOL File:: 65996-58-9.mol

Last updated:2025-07-24 18:13:50

Request For Quotation

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) Properties

Melting point	>300 °C(Solv: water (7732-18-5))
Density	1.87±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	10.85±0.20(Predicted)
form	Solid
color	Beige
FDA UNII	H2O1DD3CAN

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08,GHS02

Signal word

Warning

Hazard statements

H302-H315-H319-H373-H226

Precautionary statements

P501-P260-P270-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P314-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P301+P312+P330-P403+P235

NFPA 704

	0
2		0

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21674	9-Deazaguanine ≥98%	65996-58-9	5mg	$62	2024-03-01	Buy
Cayman Chemical	21674	9-Deazaguanine ≥98%	65996-58-9	10mg	$115	2024-03-01	Buy
Cayman Chemical	21674	9-Deazaguanine ≥98%	65996-58-9	25mg	$254	2024-03-01	Buy
Cayman Chemical	21674	9-Deazaguanine ≥98%	65996-58-9	50mg	$477	2024-03-01	Buy
Usbiological	007574	9-Deazaguanine	65996-58-9	25mg	$403	2021-12-16	Buy

Product number	Packaging	Price	Buy
21674	5mg	$62	Buy
21674	10mg	$115	Buy
21674	25mg	$254	Buy
21674	50mg	$477	Buy
007574	25mg	$403	Buy

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) Chemical Properties,Uses,Production

Description

9-Deazaguanine is an analog of guanine that acts as an inhibitor of purine nucleoside phosphorylase (PNP; K_d = 160 nM). Inhibitors of PNP are used to control T cell proliferation, particularly in T cell cancers, autoimmune diseases, and tissue transplant rejection.

Chemical Properties

Beige Solid

Uses

A nucleoside analog as potent inhibitor of purine nucleoside phosphorylase.

Synthesis

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-3,5-dihydro-3-(phenylmethyl)-

224946-82-1

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)

65996-58-9

General procedure for the synthesis of 2-amino-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one from the compound (CAS: 224946-82-1): 2-amino-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (10 g, 0.04 mol) was dissolved in methanol (334 mL), 10% Pd/C (2 g) and formic acid ammonium (13.2 g, 0.21 mol). The reaction mixture was heated at 75°C for 4 hours. After completion of the reaction, the reaction mixture was cooled and filtered through a diatomaceous earth pad with hot 1:1 DMF/MeOH solvent mixture. The filtrate was concentrated under vacuum to afford the off-white solid product 2-amino-3-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one (6.2 g, 99% yield).

References

[1] Patent: WO2006/122003, 2006, A2. Location in patent: Page/Page column 32; 36

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) Preparation Products And Raw materials

Raw materials

Methanimidamide, N'-(4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-2-yl)-N,N-dimethyl- Methanimidamide, N'-[4-[(1E)-2-(dimethylamino)ethenyl]-1,6-dihydro-5-nitro-6-oxo-2-pyrimidinyl]-N,N-dimethyl- 1,3-Bis(methoxycarbonyl)-2-methyl-2-thiopseudoeura 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-3,5-dihydro-3-(phenylmethyl)- 1H-Pyrrole-2-carboxylic acid, 3-amino-, ethyl ester

Methanol Ammonium formate

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Preparation Products

7-DEAZAGUANOSINE

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) Suppliers

Global( 85)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	21993	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9985	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38838	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49983	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
Dideu Industries Group Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
NewCan Biotech Limited	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58

View Lastest Price from 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-05-01	9-Deazaguanine 65996-58-9	US $31.00 / mg			10g	TargetMol Chemicals Inc.
	2019-07-06	4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) 65996-58-9	US $3.00 / KG	1KG	90%-99.9%	50kg	Career Henan Chemical Co

9-Deazaguanine
65996-58-9
US $31.00 / mg
TargetMol Chemicals Inc.

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)
65996-58-9
US $3.00 / KG
90%-99.9%
Career Henan Chemical Co

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) Spectrum

4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)(65996-58-9)MS 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)(65996-58-9)¹HNMR 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)(65996-58-9)IR1 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI)(65996-58-9)IR2

65996-58-9(4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI))Related Search:

4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-1,7-dihydro- (9CI) 2H-Pyrrolo[2,3-d]pyrimidin-2-one, 4-amino-1,7-dihydro- (9CI) 6H-Pyrrolo[3,2-d]pyrimidin-6-one, 4-amino-5,7-dihydro- (9CI) 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 7-amino-1,5-dihydro- (9CI) 9-DEAZA-2'-DEOXYGUANOSINE (2-AMINO-7-(BETA-D-2-DEOXYRIBOFURANOSYL)PYRROLO[3,2-D]PYRIMIDIN-4-ONE)

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2-amino-1H-pyrrolo[3,2-d]pyrimidin-4(5H)-one 2-amino-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 2-amino-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) 2-AMINO-3,5-DIHYDRO-PYRROLO[3,2-D]PYRIMIDIN-4-ONE 4H-Pyrrolo3,2-dpyrimidin-4-one, 2-amino-1,5-dihydro- 9-deazaguanine 2-amino-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one 2-Amino-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one NSC 344522 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-3,5-dihydro- 4H-Pyrrolo[3,2-d]pyrimidin-4-one, 2-amino-1,5-dihydro- (9CI) USP/EP/BP 2-Amino-3,5-dihydropyrrolo[3,2-D]pyrimidine-4-one 65996-58-9 Heterocycles Nucleotides Heterocyclic Compounds Bases & Related Reagents AMINEPRIMARY PYRIMIDINE