4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 118811-07-7
- Chemical Name:
- 4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 4-(tosyloxy)piperidine-1-carboxylate;1-Boc-4-(tosyloxy)piperidine;104618;Pozitinib intermediate 7;N-BOC-4-TOXYLOXY-PIPERIDINE;(1-BOC-piperidin-4-yl)tosylate;N-Boc-4-piperidyl p-Methylbenzenesulfonate;t-Butyl 4-(tosyloxy)piperidine-1-carboxylate;4-Tosyloxypiperidine-1-carboxylic Acid tert-Butyl Es;1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine
- CBNumber:
- CB81118751
- Molecular Formula:
- C17H25NO5S
- Molecular Weight:
- 355.45
- MDL Number:
- MFCD06796535
- MOL File:
- 118811-07-7.mol
- TDS File:
- TDS
| Melting point | 96.0 to 100.0 °C |
|---|---|
| Boiling point | 475.3±38.0 °C(Predicted) |
| Density | 1.23±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -2.97±0.40(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C17H25NO5S/c1-13-5-7-15(8-6-13)24(20,21)23-14-9-11-18(12-10-14)16(19)22-17(2,3)4/h5-8,14H,9-12H2,1-4H3 |
| InChIKey | IKOMRHLHPZAEMV-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(OS(C2=CC=C(C)C=C2)(=O)=O)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 |
| HS Code | 2933399990 |
4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4516 | 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine >98.0%(HPLC) | 118811-07-7 | 1g | $38 | 2025-07-31 | Buy |
| TCI Chemical | B4516 | 1-(tert-Butoxycarbonyl)-4-(p-toluenesulfonyloxy)piperidine >98.0%(HPLC) | 118811-07-7 | 5g | $132 | 2021-12-16 | Buy |
| Usbiological | 291821 | 4-(Toluene-4-sulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester Asreported | 118811-07-7 | 10g | $319 | 2026-06-03 | Buy |
| Usbiological | 291821 | 4-(Toluene-4-sulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester Asreported | 118811-07-7 | 25g | $432 | 2026-06-03 | Buy |
| Usbiological | 291821 | 4-(Toluene-4-sulfonyloxy)piperidine-1-carboxylic acid tert-butyl ester Asreported | 118811-07-7 | 50g | $573 | 2026-06-03 | Buy |
4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Synthesis
98-59-9
109384-19-2
118811-07-7
To a solution of N-Boc-4-hydroxypiperidine (5 g, 24.8 mmol) in dichloromethane (50 mL) was sequentially added triethylamine (13.9 mL, 99.4 mmol) and p-toluenesulfonyl chloride (9.47 g, 49.7 mmol). The reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the solution was concentrated in vacuum. The residue was redissolved in a mixture of dichloromethane (20 mL) and water (20 mL) and the organic layer was extracted with dichloromethane (20 mL). Subsequently, the organic layer was washed with 1N HCl (40 mL) and extracted twice more with dichloromethane (2 x 40 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. Finally, the crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 8:2) to afford tert-butyl 4-(toluene-4-sulfonyloxy)piperidine-1-carboxylate (8.7 g, quantitative yield) as a white crystalline solid.
References
[1] Patent: WO2018/50771, 2018, A1. Location in patent: Page/Page column 72
[2] Patent: WO2007/102883, 2007, A2. Location in patent: Page/Page column 36-37
[3] Patent: WO2013/170072, 2013, A2. Location in patent: Paragraph 001074
[4] Patent: WO2007/30366, 2007, A1. Location in patent: Page/Page column 135
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 9958 - 9972
4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
View Lastest Price from 4-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | 1-Boc-4-(tosyloxy)piperidine
118811-07-7
|
1g | 98% | 1000g | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
118811-07-7
|
1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 1-Boc-4-(tosyloxy)piperidine
118811-07-7
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
118811-07-7
- $0.00
- 98%
- Career Henan Chemical Co
