[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)-
![[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)- Structure](CAS/20211123/GIF/2763602-59-9.gif)
- CAS No.
- 2763602-59-9
- Chemical Name:
- [1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)-
- Synonyms
- 3-(difluoromethyl)-5-[1-(2,3,6,7-tetrahydrooxepin-4-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]pyridine;[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)-
- CBNumber:
- CB812376496
- Molecular Formula:
- C21H17F2N5O
- Molecular Weight:
- 393.4
- MDL Number:
- MOL File:
- 2763602-59-9.mol
- MSDS File:
- SDS
[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 43707 | BAY-8400 ≥98% | 2763602-59-9 | 1mg | $83 | 2026-04-30 | Buy |
| Cayman Chemical | 43707 | BAY-8400 ≥98% | 2763602-59-9 | 5mg | $330 | 2026-04-30 | Buy |
| Cayman Chemical | 43707 | BAY-8400 ≥98% | 2763602-59-9 | 10mg | $495 | 2026-04-30 | Buy |
| Cayman Chemical | 43707 | BAY-8400 ≥98% | 2763602-59-9 | 25mg | $1032 | 2026-04-30 | Buy |
| ChemScene | CS-0200337 | BAY-8400 99.38% | 2763602-59-9 | 1mg | $173 | 2026-06-04 | Buy |
[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)- Chemical Properties, Uses, Production
Uses
BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer[1].
in vivo
BAY-8400 (150 mg/kg; p.o.) increases the antitumor efficacy. BAY-8400 shows useful aqueous solubility and oral bioavailability across species[1].
References
[1] Berger M, et al. BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies [published online ahead of print, 2021 Aug 24]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00762. DOI:10.1021/acs.jmedchem.1c00762
[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
[1,2,4]Triazolo[4,3-a]quinoxaline, 8-[5-(difluoromethyl)-3-pyridinyl]-1-(2,3,6,7-tetrahydro-4-oxepinyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9711 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 4573 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Changsha Fuzhen Biotechnology Co.，LTD | 15111215862 18229892877 | 3062105966@qq.com | China | 5568 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
