thielavin B
- CAS No.
- 71950-67-9
- Chemical Name:
- thielavin B
- Synonyms
- thielavin B;4-[(2,4-Dihydroxy-3,6-dimethylbenzoyl)oxy]-2-methoxy-3,5,6-trimethylbenzoic acid 4-carboxy-3-methoxy-2,5,6-trimethylphenyl ester
- CBNumber:
- CB81400007
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD11111623
- MOL File:
- 71950-67-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble |
| form | White to off-white powder. |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChIKey | UULGWGARYDGVBM-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(OC)C(C)=C(OC(C2=C(O)C(C)=C(O)C=C2C)=O)C(C)=C1C)OC3=C(C)C(C)=C(C(O)=O)C(OC)=C3C |
| UNSPSC Code | 12352205 |
| NACRES | NA.25 |
thielavin B price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00566 | Thielavin B ≥95% (LC/MS-UV) | 71950-67-9 | 1mg | $795 | 2026-04-30 | Buy |
| Cayman Chemical | 18770 | Thielavin B ≥95% | 71950-67-9 | 500μg | $401 | 2026-04-30 | Buy |
| Cayman Chemical | 18770 | Thielavin B ≥95% | 71950-67-9 | 2.5mg | $1197 | 2026-04-30 | Buy |
| Usbiological | T5006-50A | Thielavin B >95%byHPLC| | 71950-67-9 | 500ug | $582 | 2026-06-04 | Buy |
| Usbiological | 467494 | Thielavin B | 71950-67-9 | 500ug | $644 | 2026-06-03 | Buy |
thielavin B Chemical Properties,Uses,Production
Description
Thielavin B is a fungal metabolite that contains O-substituted salicylic acid. It inhibits cyclooxygenase, blocking both the conversion of arachidonic acid to Prostaglandin H2 (PGH2) and the conversion of PGH2 to PGE2 (, IC50s = 40 and 9 μM, respectively). Thielavin B also inhibits the reverse transcriptase of avian myeloblastosis virus, bacterial transglycosylases, and telomerase activity.
Uses
Thielavin B is a fungal metabolite closely related to thielavin A but reported to have a slightly different biochemical profile. Thielavins inhibit glucose-6-phosphatase. Thielavin B is a potent inhibitor of phospholipase C, and inhibits peptidoglycan formation and prostaglandin biosynthesis.
Uses
Thielavin B is a fungal metabolite ofThielavia terricola that contains O-substituted salicylic acid. It is an inhibitor of viral reverse transcriptase and telomerase.
General Description
Natural product derived from fungal source.
References
[1] N MANI. Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus.[J]. Journal of Antibiotics, 1998, 51 5: 471-479. DOI: 10.7164/antibiotics.51.471
[2] KEN-ICHI TOGASHI. Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B[J]. Bioscience, Biotechnology, and Biochemistry, 2001, 65 1: 651-653. DOI: 10.1271/bbb.65.651
thielavin B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8857 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
