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2-Bromo-3-methylthiophene

2-Bromo-3-methylthiophene structure

CAS No.: 14282-76-9

Chemical Name:: 2-Bromo-3-methylthiophene

Synonyms: 2B3MT;178.04;TH1-Br;2-Bromo-3-methylthio;2-bromo-3-methyltiophene;3-Methyl-2-bromothiophene;2-BROMO-3-METHYLTHIOPHENE;Thiophene,2-bromo-3-methyl-;2-Bromo-3-methylthiophene>2-Bromo-3-methylthiophene 97%

CBNumber:: CB8147031

Molecular Formula:: C5H5BrS

Molecular Weight:: 177.06

MDL Number:: MFCD00059741

MOL File:: 14282-76-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:34:00

Product description	Number	Pack Size	Price
2-Bromo-3-methylthiophene 95%	337021	1g	$26.4
2-Bromo-3-methylthiophene 95%	337021	5g	$71.7
2-Bromo-3-methylthiophene >98.0%(GC)	B1025	5g	$40
2-Bromo-3-methylthiophene >98.0%(GC)	B1025	25g	$116
2-Bromo-3-methylthiophene Asreported	261620	10g	$337
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2-Bromo-3-methylthiophene Properties

Melting point	<25 °C
Boiling point	173-176 °C (lit.)
Density	1.572 g/mL at 25 °C (lit.)
refractive index	n20/D 1.572(lit.)
Flash point	155 °F
storage temp.	2-8°C
Water Solubility	Insoluble in water
solubility	soluble in Chloroform, Ethyl Acetate
form	liquid
color	Pale yellow
Specific Gravity	1.580
BRN	105719
InChI	InChI=1S/C5H5BrS/c1-4-2-3-7-5(4)6/h2-3H,1H3
InChIKey	YYJBWYBULYUKMR-UHFFFAOYSA-N
SMILES	C1(Br)SC=CC=1C
CAS DataBase Reference	14282-76-9(CAS DataBase Reference)
NIST Chemistry Reference	Thiophene, 2-bromo-3-methyl-(14282-76-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P280-P305+P351+P338

Hazard Codes

T,Xi,Xn

Risk Statements

25-41-43-36/37/38-20/21/22

Safety Statements

26-36/37/39-45

RIDADR

UN 2810

WGK Germany

Hazard Note

Harmful

HazardClass

IRRITANT-HARMFUL, KEEP COLD

HazardClass

6.1

PackingGroup

III

HS Code

29349990

Limited Quantities

5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	2
2		0

2-Bromo-3-methylthiophene price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	337021	2-Bromo-3-methylthiophene 95%	14282-76-9	1g	$26.4	2023-06-20	Buy
Sigma-Aldrich	337021	2-Bromo-3-methylthiophene 95%	14282-76-9	5g	$71.7	2023-06-20	Buy
TCI Chemical	B1025	2-Bromo-3-methylthiophene >98.0%(GC)	14282-76-9	5g	$40	2026-04-30	Buy
TCI Chemical	B1025	2-Bromo-3-methylthiophene >98.0%(GC)	14282-76-9	25g	$116	2026-04-30	Buy
Usbiological	261620	2-Bromo-3-methylthiophene Asreported	14282-76-9	10g	$337	2026-06-03	Buy

Product number	Packaging	Price	Buy
337021	1g	$26.4	Buy
337021	5g	$71.7	Buy
B1025	5g	$40	Buy
B1025	25g	$116	Buy
261620	10g	$337	Buy

2-Bromo-3-methylthiophene Chemical Properties,Uses,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

2-Bromo-3-methylthiophene was used in the preparation of poly(3,3′′′-dimethyl-(2,2′:5′,2′:5′,2′′′)tetrathiophene)). It was also used in the preparation of 2-bromo-3-(bromomethyl)thiophene, lachrymatory compound.

Application

2-Bromo-3-methylthiophene is used as a pharmaceutical intermediate. It is used to prepare pyrazolo[3,4-d]pyrimidine derivatives as inhibitors of human enterovirus, coxsackievirus, echovirus, influenza virus, herpes simplex virus and rhinovirus. It is also used in the synthesis of oral α7 nicotinic receptor agonists.

Preparation

2-Bromo-3-methylthiophene synthesis: To a solution of glacial AcOH (100 mL), acetic anhydride (4.0 g, 0.039 mol), and 3-methylthiophene (9.82 g, 0.100 mol) as a stirred mixture was added NBS (19.6 g, 0.11 mol) in one portion with a slight exotherm to 44 oC. After 20 min the reaction mixture was poured onto ice, neutralized with sodium bisulfite and extracted with ether. The ether layer was washed with water and concentrated to give 11.3 g (64%) of 2-bromo-3-methylthiophene as a tan colored liquid in 88% purity by GC area % analysis: 1H NMR (CDCl3) d 7.1 (d, 1H, J=5.7 Hz), 6.7 (d, 1H, J=5.9 Hz), 2.2 (s, 3H).

General Description

2-Bromo-3-methylthiophene is formed (approx. 90%) by bromination of 3-methyl thiophene with N-bromosuccinimide in the absence of benzoyl peroxide.

Synthesis

616-44-4

14282-76-9

General procedure for the synthesis of 2-bromo-3-methylthiophene from 3-methylthiophene: N-bromosuccinimide (NBS, 8.90 g, 50.0 mmol) was added in batches to a stirred solution of 3-methylthiophene (4.90 g, 50.0 mmol) in acetic acid (20 mL) at room temperature. After the addition was completed, the reaction mixture continued to be stirred at room temperature until the reaction was complete. Subsequently, the reaction mixture was slowly poured into ice water and extracted with a 3:1 solvent mixture of hexane and ether. The organic layer was washed sequentially with 1N NaOH aqueous solution and saturated saline. After drying over anhydrous sodium sulfate, the organic phase was concentrated under reduced pressure to afford the crude product 2-bromo-3-methylthiophene (8.20 g, 92.7% yield), which could be used in subsequent reactions without further purification.

References

[1] Chemistry Letters, 2014, vol. 43, # 5, p. 640 - 642
[2] Synthetic Communications, 1999, vol. 29, # 9, p. 1607 - 1610
[3] Bulletin of the Chemical Society of Japan, 2016, vol. 89, # 12, p. 1480 - 1486
[4] Patent: WO2012/116452, 2012, A1. Location in patent: Page/Page column 66
[5] Macromolecules, 2013, vol. 46, # 21, p. 8488 - 8499

2-Bromo-3-methylthiophene synthesis

Synthesis of 2-Bromo-3-methylthiophene from N-Bromosuccinimide and 3-Methylthiophene

2-Bromo-3-methylthiophene Preparation Products And Raw materials

Raw materials

Acetic acid Acetic anhydride 3-Methylthiophene N-Bromosuccinimide

Preparation Products

3-METHYLTHIOPHENE-2-BORONIC ACID 2,3,5-Trimethylthiophene 3-METHYLTHIOPHENE-2-BORONIC ACID PINACOL ESTER 2-BROMOTHIOPHENE-3-CARBALDEHYDE 2-[(5-BROMO-2-THIENYL)CARBONYL]BENZENECARBOXYLIC ACID

4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone MTPPA

1of2

2-Bromo-3-methylthiophene Suppliers

Global( 410)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413	contact@trustwe.com	China	5742	58
Hebei Yanxi Chemical Co., Ltd.	+86-17531190177	faithe@yan-xi.com	China	5838	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325	sales1@chuanghaibio.com	China	5216	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-17732866630	mina@chuanghaibio.com	China	18112	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7239	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14034	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1796	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3004	60

Supplier	Advantage
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from 2-Bromo-3-methylthiophene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-17	2-Bromo-3-methylthiophene 14282-76-9	$9.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2026-08-14	2-Bromo-3-methylthiophene 14282-76-9	$5.00	1kg	≥99%	200mt/year	Jinan Finer Chemical Co., Ltd
2026-05-28	2-Bromo-3-Methylthiophene 14282-76-9	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD

2-Bromo-3-methylthiophene
14282-76-9
$9.00
99%
Henan Fengda Chemical Co., Ltd

2-Bromo-3-methylthiophene
14282-76-9
$5.00
≥99%
Jinan Finer Chemical Co., Ltd

2-Bromo-3-Methylthiophene
14282-76-9
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

2-Bromo-3-methylthiophene Spectrum

2-Bromo-3-methylthiophene(14282-76-9)MS 2-Bromo-3-methylthiophene(14282-76-9)¹HNMR 2-Bromo-3-methylthiophene(14282-76-9)¹³CNMR 2-Bromo-3-methylthiophene(14282-76-9)IR1

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2-Bromo-3-bromomethylthiophene Bromine 3-bromo-2-methylthiophene

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Thiophene,2-bromo-3-methyl- 2B3MT 2-BROMO-3-METHYLTHIOPHENE 2-Bromo-3-Methylthiophene99.5% 2-bromo-3-methyltiophene 2-Bromo-3-methylthiophene 97% 178.04 2-BROMO-3-METHYLTHIOPHENE 98+% 2-Bromo-3-methyl-thiophene ,97% 3-Methyl-2-bromothiophene 2-Bromo-3-methylthio 2 - broMine - 3 - Methyl thiophene 1-[2-[(2-BROMO-3-THIENYL)METHOXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE TH1-Br 2-Bromo-3-methylthiophene> 2-Bromo-3-methylthiophene ISO 9001：2015 REACH https://www.chemicalbook.com/ProdSupplierGNCB8147031.htm 14282-76-9 14282-75-9 C5H5Br Thiophenes Halogenated Heterocycles Heterocyclic Building Blocks ARYL HALIDE Building Blocks Building Blocks C4 to C6 Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Heterocycle-oher series Thiophene Series Halogenated Heterocycles Heterocyclic Building Blocks ThiophenesBuilding Blocks Halogenated Organohalides Thiophene Thiophens blocks Bromides Heterocycles Thiophene&Benzothiophene Thiophenes