16a,17a-Epoxyprogesterone
- CAS No.
- 1097-51-4
- Chemical Name:
- 16a,17a-Epoxyprogesterone
- Synonyms
- 16,17a-Epoxyprogesterone;W-oxide;ZK-5197;Wobbe's oxide;Waugh's oxide;Albright oxide;Wolfowitz oxide;EPOXY PROGESTERONE;16a,17a-Epoxyprogest;16,17-EPOXYPROGESTERONE
- CBNumber:
- CB8156077
- Molecular Formula:
- C21H28O3
- Molecular Weight:
- 328.45
- MDL Number:
- MFCD00055948
- MOL File:
- 1097-51-4.mol
- MSDS File:
- SDS
| Melting point | 200C |
|---|---|
| Boiling point | 466.9±45.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| refractive index | 168 ° (C=1, CHCl3) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform, Methanol |
| form | Solid |
| color | Off-White |
| CAS DataBase Reference | 1097-51-4(CAS DataBase Reference) |
| FDA UNII | F2DR02G069 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | TU5022000 |
16a,17a-Epoxyprogesterone price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-E589580-5G | 16Alpha,17Alpha-Epoxyprogesterone | 1097-51-4 | 5g | $154 | 2026-06-03 | Buy |
| TRC | TRC-E589580-2.5G | 16Alpha,17Alpha-Epoxyprogesterone | 1097-51-4 | 2.5g | $109 | 2026-06-03 | Buy |
| TRC | TRC-E589580-1G | 16Alpha,17Alpha-Epoxyprogesterone | 1097-51-4 | 1g | $72 | 2026-06-03 | Buy |
| ChemScene | CS-0145392 | 16α,17α-Epoxyprogesterone ≥95% | 1097-51-4 | 100g | $68 | 2026-06-04 | Buy |
| aablocks | AA003DSP | (6aR,6bS,8aS,8bS,9aR,10aS,10bR)-8b-Acetyl-6a,8a-dimethyl-5,6,6a,6b,7,8,8a,8b,9a,10,10a,10b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-b]oxiren-4(2H)-one ≥98% | 1097-51-4 | 1g | $13 | 2026-05-28 | Buy |
16a,17a-Epoxyprogesterone Chemical Properties, Uses, Production
Uses
16α,17α-Epoxyprogesterone is hydrolyzed by Rhizopus nigricans for the synthesis of many steroidal drugs.
Definition
ChEBI: 16-alpha,17-Epoxypregn-4-ene-3,20-dione is a corticosteroid hormone.
Synthesis
2872-76-6
1097-51-4
The general procedure for the synthesis of 16,17-epoxyprogesterone from the compound (CAS: 2872-76-6) was as follows: 0.496 g of compound (III) (1.5 × 10^-3 mol) was dissolved in 30 mL of acetone and the reaction system was cooled to 0 °C. Subsequently, 0.48 mL of conditioned Jones' reagent was slowly added (preparation of Jones' reagent: 2.67 g of CrO3 was dissolved in 2.3 mL of concentrated sulfuric acid and then diluted to 10 mL with water). After stirring the reaction mixture for 1 h at 0 °C, the progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was completed. Upon completion of the reaction, 0.5 mL of isopropanol was added to the system to quench the reaction, followed by distillation under reduced pressure to remove the acetone. The reaction mixture was extracted three times with 20 mL of ethyl acetate and the organic phases were combined. The organic phase was washed sequentially with saturated sodium bicarbonate solution and saturated brine, and then dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography to afford 0.446 g of white solid 16α,17α-epoxypregn-4-ene-3,20-dione (IV) in 90.6% isolated yield.
References
[1] Patent: CN104610421, 2017, B. Location in patent: Paragraph 0015; 0036; 0037; 0038; 0039
16a,17a-Epoxyprogesterone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
View Latest Price from 16a,17a-Epoxyprogesterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | 16a,17a-Epoxy-4-Pregnen-3,20-Dione
1097-51-4
|
$29.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-12-24 | 16a,17a-Epoxyprogesterone
1097-51-4
|
$665.00 | 1KG | 98.0% | 1T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-31 | 16,17a-Epoxy-Progesterone
1097-51-4
|
$1.00 | 1g | 99% | 100 Metric Ton/Metric Tons per Month | Cangzhou Wanyou New Material Technology Co.,Ltd |
-
- 16a,17a-Epoxy-4-Pregnen-3,20-Dione
1097-51-4
- $29.00
- 99.89%
- TargetMol Chemicals Inc.
-
- 16a,17a-Epoxyprogesterone
1097-51-4
- $665.00
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 16,17a-Epoxy-Progesterone
1097-51-4
- $1.00
- 99%
- Cangzhou Wanyou New Material Technology Co.,Ltd
