ChemicalBook >> CAS DataBase List >>2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate structure

CAS No.: 122111-11-9

Chemical Name:: 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate

Synonyms: GCTB-T8;ER-878898;acid(TES);Gemcitabine salt;GeMcitabine InterMediate 8;"2-Deoxy-2,2-difluoro-D-erythro-;((2R,3R)-3-(benzoyloxy)-4,4-difluoro;2-Deoxy-2,2-difluoro-D-erythro-pentofura...;2-DEXY-2,2-DIFLUORO-3,5-O-DIBENZOYLRIBOSE MESYLATE;D-erythro-Pentofuranose, 2-deoxy-2,2-difluoro-, 3,5-dibenzoate-1-

CBNumber:: CB8187886

Molecular Formula:: C20H18F2O8S

Molecular Weight:: 456.41

MDL Number:: MFCD08460089

MOL File:: 122111-11-9.mol

Last updated:2025-07-24 18:13:43

Product description	Number	Pack Size	Price
2-Deoxy-2,2-difluoro-D-erythro-ribofuranose-3,5-dibenzoate 1-Methanesulfonate	008073	50mg	$425
2-Deoxy-2,2-difluoro-D-erythro-ribofuranose-3,5-dibenzoate1-Methanesulfonate	D232790	500mg	$1210
2-DEOXY-2,2-DIFLUORO-D-ERYTHRO-RIBOFURANOSE-3,5-DIBENZOATE 1-METHANESULFONATE 95.00%	CRB0000194	500MG	$1732.5
2-Deoxy-2,2-difluoro-3,5-O-dibenzoylribosemesylate	B651	100g	$717
2-DEOXY-2,2-DIFLUORO-D-ERYTHRO-RIBOFURANOSE-3,5-DIBENZOATE 1-METHANESULFONATE 95.00%	CRB0000194	50MG	$721.88
More product size

Request For Quotation

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate Properties

Melting point	66-74°C
Boiling point	588.4±50.0 °C(Predicted)
Density	1.46±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform, Methanol
form	Solid
color	Off-White to Pale Yellow
optical activity	96.07°(C=0.01g/ml CHCL3)
InChI	InChI=1S/C20H18F2O8S/c1-31(25,26)30-19-20(21,22)16(29-18(24)14-10-6-3-7-11-14)15(28-19)12-27-17(23)13-8-4-2-5-9-13/h2-11,15-16,19H,12H2,1H3/t15-,16-,19?/m1/s1
InChIKey	LIAQHZDWFACWFK-QNRNLVPOSA-N
SMILES	C1(OS(C)(=O)=O)O[C@H](COC(=O)C2=CC=CC=C2)[C@@H](OC(=O)C2=CC=CC=C2)C1(F)F
CAS DataBase Reference	122111-11-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	008073	2-Deoxy-2,2-difluoro-D-erythro-ribofuranose-3,5-dibenzoate 1-Methanesulfonate	122111-11-9	50mg	$425	2021-12-16	Buy
TRC	D232790	2-Deoxy-2,2-difluoro-D-erythro-ribofuranose-3,5-dibenzoate1-Methanesulfonate	122111-11-9	500mg	$1210	2021-12-16	Buy
American Custom Chemicals Corporation	CRB0000194	2-DEOXY-2,2-DIFLUORO-D-ERYTHRO-RIBOFURANOSE-3,5-DIBENZOATE 1-METHANESULFONATE 95.00%	122111-11-9	500MG	$1732.5	2021-12-16	Buy
AK Scientific	B651	2-Deoxy-2,2-difluoro-3,5-O-dibenzoylribosemesylate	122111-11-9	100g	$717	2021-12-16	Buy
American Custom Chemicals Corporation	CRB0000194	2-DEOXY-2,2-DIFLUORO-D-ERYTHRO-RIBOFURANOSE-3,5-DIBENZOATE 1-METHANESULFONATE 95.00%	122111-11-9	50MG	$721.88	2021-12-16	Buy

Product number	Packaging	Price	Buy
008073	50mg	$425	Buy
D232790	500mg	$1210	Buy
CRB0000194	500MG	$1732.5	Buy
B651	100g	$717	Buy
CRB0000194	50MG	$721.88	Buy

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate Chemical Properties,Uses,Production

Chemical Properties

Brown Liquid

Uses

Gemcitabine intermediate.

Synthesis

124-63-0

2-deoxy-2,2-difluoro-D-erythro-Pentofuranose-3,5-dibenzoate

1173824-58-2

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate

134877-42-2

((2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-hydroxytetrahydrofuran-2-yl)methyl benzoate (4.14 g, 10.9 mmol) was dissolved in anhydrous dichloromethane (52 mL), anhydrous triethylamine (2.4 mL) was added, and the solution was cooled to 0 °C. Methylsulfonyl chloride (1.23 mL, 15.8 mmol) was added slowly and dropwise with stirring. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was diluted with dichloromethane (140 mL) and washed with saturated sodium bicarbonate solution (56 mL). The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give an oily product as a mixture of isomers (5.03 g, quantitative yield). 19F NMR (CDCl3, 471 MHz): δ -107.70, -108.22, -120.65, -121.17, -122.21, -122.73, -123.76, -124.45. 1H NMR (CDCl3, 500 MHz) of the major isomer (60%): δ 8.13-8.04 (m, 4H, Bz), 7.65-7.54 (m, 2H, Bz), 7.50-7.41 (m, 4H, Bz), 6.17 (d, J = 5.6 Hz, 1H, H-1), 5.62 (dd, J1 = 4.2 Hz, J2 = 16.4 Hz), 5.62 (dd, J1 = 16.4 Hz, J2 = 16.4 Hz, J2 = 16.4 Hz). J2 = 16.4 Hz, 1H, H-3), 4.91 (q, J = 3.9 Hz, 1H, H-4), 4.81-4.61 (m, 2H, H-5), 3.17 (s, 3H, CH3). 1H NMR (CDCl3, 500 MHz) of the secondary isomer (40%): δ 8.13-8.04 (m, 4H, Bz), 7.65-7.54 (m, 2H, Bz), 7.50-7.41 (m, 4H, Bz), 6.09 (d, J = 6.4 Hz, 1H, H-1), 5.98 (dt, J1 = 7.3 Hz, J2 = 15.0 Hz, 1H, H-3), 4.81-4.61 (m, 3H, H-4, H-5), 3.03 (s, 3H, CH3). 13C NMR (CDCl3, 126 MHz): δ 40.09, 40.20 (CH3), 62.52, 63.08 (C-5), 69.61 (dd, J1C-F = 15.7 Hz, J2C-F = 26.0 Hz, C-3), 71.04 (dd, J1C-F = 17.4 Hz, J2C-F = 36.4 Hz C-3), 79.68, 79.75, 82.59 (C-4), 98.81 (dd, J1C-F = 25.0 Hz, J2C-F = 41.8 Hz, C-1), 99.52 (dd, J1C-F = 24.5 Hz, J2C-F = 46.3 Hz, C-1), 120.61 (dd, J1C-F = 253.5 Hz, J2C-F = 269.8 Hz, C-2), 120.91 (dd, J1C-F = 249.3 Hz, J2C-F = 276.3 Hz, C-2), 128.42, 128.58, 128.63, 128.70, 128.76, 128.79 (Ph), 129.18, 129.25 ('ipso ' Ph), 129.76, 130.07, 130.14, 133.51, 133.63, 134.19, 134.26 (Ph), 164.89, 165.03, 165.81, 165.90 (CO).

References

[1] Synthesis, 1992, # 6, p. 565 - 570
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 14, p. 4338 - 4345
[3] Patent: WO2009/61781, 2009, A1. Location in patent: Page/Page column 102-103
[4] Biochemistry, 2010, vol. 49, # 7, p. 1404 - 1417
[5] Patent: WO2005/95430, 2005, A1. Location in patent: Page/Page column 18

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate Preparation Products And Raw materials

Raw materials

Methanesulfonyl chloride 2-deoxy-2,2-difluoro-D-erythro-Pentofuranose-3,5-dibenzoate Dichloromethane Triethylamine

Preparation Products

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate Suppliers

Global( 236)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Toachem Chemical Co.,Ltd	+8618311365218	sales@toachem.com	China	217	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21620	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29852	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2953	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Beijing Toachem Chemical Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58
Xiamen AmoyChem Co., Ltd	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-24	2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate 122111-11-9	US $0.00 / kg	1kg	98%	1 Ton	Shanghai Joiny Pharmaceutical Co.,LTD
2021-07-13	2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate 122111-11-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate 122111-11-9	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate
122111-11-9
US $0.00 / kg
98%
Shanghai Joiny Pharmaceutical Co.,LTD

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate
122111-11-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate
122111-11-9
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

122111-11-9(2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate)Related Search:

Pazufloxacin mesilate Imatinib Gabexate mesylate Levofloxacin Methylate Methyl methanesulfonate

Trifluoromethanesulfonic acid N-Carboxybenzyl GeMcitabine Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate 2-Deoxy-2,2-difluoro-D-erythro-pentafuranous-1-ulose-3,5-dibenzoate Gemcitabine

Methanesulfonic acid α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate 2-DEOXY-2-FLUORO-D-ARABINOFURANOSE 2-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSE-3,5-DIBENZOATE-1-METHANESULFONATE 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate

1of3

D-ERYTHRO-PENTOFURANOSE, 2-DEOXY-2,2-DIFLUORO-, 3,5-DIBENZOATE 1-METHANESULFONATE 2-deoxy-2,2-difluoro-d-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate 2-DEXY-2,2-DIFLUORO-3,5-O-DIBENZOYLRIBOSE MESYLATE 2-Deoxy-2,2-difluoro-D-erythro-ribofuranose-3,5-dibenzoate 1-Methanesulfonate GeMcitabine InterMediate 8 T8, 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-Methanesulfonate ((2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-((Methylsulfonyl)oxy)tetrahydrofuran-2-yl)Methyl benzoate 3,5-Di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-ribofuranoside benzoic acid (3-benzoyloxy-4,4-difluoro-5-methylsulfonyloxy-2-oxolanyl)methyl ester 2-Deoxy-2,2-difluoro-D-erythro-pentofura... ER-878898 D-erythro-Pentofuranose, 2-deoxy-2,2-difluoro-, 3,5-dibenzoate-1- 2-Deoxy-2,2-difluoro-D- erythro –pentofuranose -3,5- dibenzoate-1- methanesulfonate (for Gemcitabine) "2-Deoxy-2,2-difluoro-D-erythro- ((2R,3R)-3-(benzoyloxy)-4,4-difluoro 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate [G-8] 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate ISO 9001：2015 REACH 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanes GCTB-T8 (2R,3S)-3-Benzoyloxy-4,4-difluoro-5-methylsulfonyloxyoxolan-2-yl]methyl benzoate(95%) (2R,3S)-3-Benzoyloxy-4,4-difluoro-5-methylsulfonyloxyoxolan-2-yl]methyl benzoate(75%) 2-deoxy-2,2-difluoro-D-cathopentafurose-3,5-diphenylmethyl-1-methanesulfonate 2-Deoxy-2,2-difluoro-D-erythro-pentafuranose-3-5-dibenzoate-1-methanesulfonate 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesul phonate 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate [T-8] (2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-[(methylsulfonyl)oxy]-2-tetrahydrofuryl]methyl Benzoate Gemcitabine salt acid(TES) 2-Deoxy-2,2-difluoro-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfote 122111-11-9 Aromatics Compounds Aromatics Carbohydrates & Derivatives Intermediates