2-Chloropyridine-4-carboxylic acid tert-butyl ester
- CAS No.
- 295349-62-1
- Chemical Name:
- 2-Chloropyridine-4-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 2-chloroisonicotinate;Methyl 2-Chloroisonicotite;2-Chloropyridine-4-carbox...;ert-butyl2-chloropyridine-4-carboxylate;2-CHLOROISONICOTINIC ACID T-BUTYL ESTER;2-CHLORO-4-PYRIDINECARBOXYLIC ACID1,1-D;tert-Butyl 2-chloropyridine-4-carboxylate;2-CHLOROISONICOTINIC ACID TERT-BUTYL ESTER;2-Chloro-4-pyridinecaroboxylic acid methyl ester;2-Chloro-4-pyridinecarboxylic acid tert-butyl ester
- CBNumber:
- CB8192031
- Molecular Formula:
- C10H12ClNO2
- Molecular Weight:
- 213.66
- MDL Number:
- MFCD03411667
- MOL File:
- 295349-62-1.mol
- MSDS File:
- SDS
| Boiling point | 287.4±20.0 °C(Predicted) |
|---|---|
| Density | 1.173±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -1.27±0.10(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 295349-62-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
2-Chloropyridine-4-carboxylic acid tert-butyl ester price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR315516 | tert-Butyl 2-chloroisonicotinate >98% | 295349-62-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR315516 | tert-Butyl 2-chloroisonicotinate >98% | 295349-62-1 | 5g | $26 | 2026-06-04 | Buy |
| Apolloscientific | OR315516 | tert-Butyl 2-chloroisonicotinate >98% | 295349-62-1 | 25g | $86 | 2026-06-04 | Buy |
| Apolloscientific | OR315516 | tert-Butyl 2-chloroisonicotinate >98% | 295349-62-1 | 100g | $282 | 2026-06-04 | Buy |
| Apolloscientific | OR315516 | tert-Butyl 2-chloroisonicotinate >98% | 295349-62-1 | 500g | $509 | 2026-06-04 | Buy |
2-Chloropyridine-4-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production
Uses
2-Chloroisonicotinic acid tert-butyl ester is a useful research chemical for organic synthesis and other chemical processes.
Synthesis
6313-54-8
36805-97-7
295349-62-1
General procedure for the synthesis of tert-butyl 2-chloroisonicotinate from 2-chloroisonicotinic acid and N,N-dimethylformamide di-tert-butyl acetal: 10.0 g (63.4 mmol) of 2-chloroisonicotinic acid was dissolved in 100 ml of chloroform and heated to reflux temperature. A total of 91.2 ml (380 mmol, 6 eq.) of N,N-dimethylformamide di-tert-butyl acetal was added in three additions of 30.4 ml each at the beginning of the reaction, after 1 h and after 2 h. Upon completion of the reaction, it was cooled down to room temperature, and the reaction mixture was diluted with ethyl acetate, washed with water, sodium bicarbonate solution, and saturated saline in that order, and dried over anhydrous sodium sulfate. The residue was purified by silica gel column chromatography (fast column chromatography, eluent gradient from hexane to hexane/ethyl acetate 95/5) to give 7.6 g (35.6 mmol, 56% yield) of white solid product. Mass spectrum (LC/MS): m/z 158 = [M + H - tBu]+. 1H-NMR (300 MHz, CDCl3): δ 8.55 (d, 1H), 7.85 (s, 1H), 7.76 (d, 1H), 1.64 (s, 9H).
References
[1] Patent: US2008/132477, 2008, A1. Location in patent: Page/Page column 28
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 1, p. 110 - 130
[3] Patent: WO2014/141171, 2014, A1. Location in patent: Page/Page column 17; 18
2-Chloropyridine-4-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloropyridine-4-carboxylic acid tert-butyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Puyang Huicheng Electronic Material Co. Ltd. | 0393-0393-8910800 15039333257 | info@huichengchem.com | China | 588 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 2-Chloropyridine-4-carboxylic acid tert-butyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-03 | 2-Chloropyridine-4-carboxylic acid tert-butyl ester
295349-62-1
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 2-Chloropyridine-4-carboxylic acid tert-butyl ester
295349-62-1
- $7.00
- 99%
- Career Henan Chemical Co
