1-Benzhydrylazetidin-3-one
- CAS No.
- 40320-60-3
- Chemical Name:
- 1-Benzhydrylazetidin-3-one
- Synonyms
- 1-(DIPHENYLMETHYL)AZETIDIN-3-ONE;1-benzhdrylazetidin-3-one;N-Benzhydrylazetidin-3-one;3-BENZHYDRYL-CYCLOBUTANONE;1-Benzhydrylazetidin-3-one;1-Diphenylmethyl-3-azetid...;N-DiphenylMethylazetidin-3-on;1-Benzhydrylazetidin-3-one 95%;1-Diphenylmethyl-3-azetidinone;1-Benzhydryl-3-azetidinone >
- CBNumber:
- CB8199186
- Molecular Formula:
- C16H15NO
- Molecular Weight:
- 237.3
- MDL Number:
- MFCD00964539
- MOL File:
- 40320-60-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 75.0 to 79.0 °C |
|---|---|
| Boiling point | 350-355℃ |
| Density | 1.182 |
| Flash point | 156°(313°F) |
| refractive index | 1.626 |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder to crystal |
| pka | 3.10±0.20(Predicted) |
| color | White to Orange to Green |
| InChI | InChI=1S/C16H15NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,16H,11-12H2 |
| InChIKey | AVUDXLOVIBJFQA-UHFFFAOYSA-N |
| SMILES | N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-Benzhydrylazetidin-3-one price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4799 | 1-Benzhydryl-3-azetidinone >96.0%(GC)(T) | 40320-60-3 | 1g | $47 | 2026-04-30 | Buy |
| TCI Chemical | B4799 | 1-Benzhydryl-3-azetidinone >96.0%(GC)(T) | 40320-60-3 | 5g | $158 | 2026-04-30 | Buy |
| Usbiological | 261751 | 1-Benzhydrylazetidin-3-one Asreported | 40320-60-3 | 5g | $340 | 2026-06-03 | Buy |
| Usbiological | 261751 | 1-Benzhydrylazetidin-3-one Asreported | 40320-60-3 | 10g | $460 | 2026-06-03 | Buy |
| Usbiological | 261751 | 1-Benzhydrylazetidin-3-one Asreported | 40320-60-3 | 25g | $638 | 2026-06-03 | Buy |
1-Benzhydrylazetidin-3-one Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
1-Benzhydrylazetidin-3-one is used in the synthesis of azetidine derivatives as novel γ-aminobutyric acid uptake inhibitors.
Synthesis
90604-02-7
40320-60-3
General procedure for the synthesis of 1-diphenylmethylazetidin-3-one: (Preparative Example 78) To a mixture of 1-diphenylmethylazetidin-3-ol hydrochloride (5.52 g) and triethylamine (27.9 ml) was added slowly and dropwise a dimethylformamide solution (80 ml) of pyridine trioxide complex (19.7 g). The reaction mixture was stirred at 50 °C for 30 min and then cooled to room temperature. The reaction mixture was poured into ice water, extracted with ethyl acetate and the organic layer was washed with brine. Activated carbon (5 g) was added to the organic layer and stirred at room temperature for 3 days. The activated carbon was removed by filtration and the filtrate was concentrated. The residue was dissolved in methanol (200 ml), activated carbon (10 g) was added and stirred at room temperature for 3 days. The activated carbon was removed by filtration again and the filtrate was concentrated. The residue was purified by silica gel column chromatography (eluent: heptane/ethyl acetate = 4:1, then 2:1). The grades containing the target compound were collected and concentrated to give a light yellow oil (3.21 g). Hexane was added to the oily material to induce crystallization and the crystals were collected by filtration. The crystals were dried under ventilated conditions to give the title compound (1.11 g, 23.4% yield). The concentrated residue of the filtrate was added to hexane and left to crystallize at room temperature. After precipitation, the supernatant was removed by pipette and dried under reduced pressure to give the light yellow crystalline title compound (940 mg, 19.8% yield).1H-NMR (CDCl3) δ (ppm): 4.01 (4H, s), 4.60 (1H, s), 7.22 (2H, m), 7.30 (4H, m), 7.48 (4H, m).
References
[1] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7029 - 7042
[3] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 83; 84
[4] Chemistry Letters, 1999, # 7, p. 605 - 606
[5] Patent: EP1889836, 2008, A1. Location in patent: Page/Page column 78
1-Benzhydrylazetidin-3-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 822 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from 1-Benzhydrylazetidin-3-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 1-BENZHYDRYLAZETIDIN-3-ONE
40320-60-3
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 1-BENZHYDRYLAZETIDIN-3-ONE
40320-60-3
|
$1.00 | 1G | 98% | 1000KG | Career Henan Chemical Co |
-
- 1-BENZHYDRYLAZETIDIN-3-ONE
40320-60-3
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 1-BENZHYDRYLAZETIDIN-3-ONE
40320-60-3
- $1.00
- 98%
- Career Henan Chemical Co
