N-Cbz-3-oxoazetidine
- CAS No.
- 105258-93-3
- Chemical Name:
- N-Cbz-3-oxoazetidine
- Synonyms
- 1-Cbz-3-azetidinone;1-(Benzyloxycarbonyl)azetidin-3-one;N-Cbz-3-oxoazetidine;1-Cbz-3-azetidinone - [C1509];Azetidin-3-one, N-CBZ protected;Benzyl 3-oxo-1-azetidinecarboxylate;3-Oxo-azetidine-1-carboxylic acid benzyl ester;3-oxo-1-azetidinecarboxylic acid (phenylmethyl) ester;1-Azetidinecarboxylic acid, 3-oxo-, phenylMethyl ester;3-Oxo-azetidine-1-carboxylic acid benzyl ester 105258-93-3
- CBNumber:
- CB82453341
- Molecular Formula:
- C11H11NO3
- Molecular Weight:
- 205.21
- MDL Number:
- MFCD09954923
- MOL File:
- 105258-93-3.mol
- MSDS File:
- SDS
| Melting point | 40-44° |
|---|---|
| Boiling point | 356.5±42.0 °C(Predicted) |
| Density | 1.308±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -2.04±0.20(Predicted) |
| form | solid |
| color | White |
| InChI | InChI=1S/C11H11NO3/c13-10-6-12(7-10)11(14)15-8-9-4-2-1-3-5-9/h1-5H,6-8H2 |
| InChIKey | VLMMTGKGDOAYER-UHFFFAOYSA-N |
| SMILES | N1(C(OCC2=CC=CC=C2)=O)CC(=O)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 29339900 |
N-Cbz-3-oxoazetidine price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 263876 | Benzyl 3-oxoazetidine-1-carboxylate Asreported | 105258-93-3 | 1g | $305 | 2026-06-03 | Buy |
| Usbiological | 263876 | Benzyl 3-oxoazetidine-1-carboxylate Asreported | 105258-93-3 | 2g | $403 | 2026-06-03 | Buy |
| Usbiological | 263876 | Benzyl 3-oxoazetidine-1-carboxylate Asreported | 105258-93-3 | 5g | $531 | 2026-06-03 | Buy |
| Usbiological | 263876 | Benzyl 3-oxoazetidine-1-carboxylate Asreported | 105258-93-3 | 10g | $672 | 2026-06-03 | Buy |
| Usbiological | 263876 | Benzyl 3-oxoazetidine-1-carboxylate Asreported | 105258-93-3 | 25g | $955 | 2026-06-03 | Buy |
N-Cbz-3-oxoazetidine Chemical Properties, Uses, Production
Synthesis
128117-22-6
105258-93-3
General procedure for the synthesis of 1-Benzyloxycarbonyl-3-hydroxyazetidin-3-one from 1-Benzyloxycarbonylazetidin-3-one: Triphenylmethyl-3-hydroxyazetidin-1-carboxylate (3.5 g, 0.0168 mol) was dissolved in dichloromethane (100 mL) at room temperature, followed by the addition of Dess-Martin periodinane (10.7 g, 0.025 mol). The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the reaction was quenched with a 1:1 ratio of saturated aqueous sodium bicarbonate and 1 M sodium thiosulfate solution (200 mL). The mixture was extracted with dichloromethane and the organic layer was separated. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to afford phenylmethyl 3-oxoazetidine-1-carboxylate (3.43 g, 99% yield), the product was a clear, colorless oil, which did not require further purification. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.39-7.31 (m, 5H), 5.17 (s, 2H), 4.77 (s, 4H). Mass spectrometry (EI) analysis was consistent with the molecular weight of C11H11NO3: 205 (M+).
References
[1] Patent: WO2007/44515, 2007, A1. Location in patent: Page/Page column 165
[2] Patent: WO2008/76415, 2008, A1. Location in patent: Page/Page column 329
[3] Patent: WO2008/124085, 2008, A2. Location in patent: Page/Page column 179
[4] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 33; 34
[5] Patent: WO2013/8002, 2013, A1. Location in patent: Page/Page column 49
N-Cbz-3-oxoazetidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Shenglan Chemical Technology Co. Ltd | 17806220283 | info@samelabs.com | China | 569 | 58 |
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 822 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 |
View Latest Price from N-Cbz-3-oxoazetidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 1-Cbz-3-azetidinone
105258-93-3
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Benzyl 3-oxo-1-azetidinecarboxylate
105258-93-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | Benzyl 3-Oxoazetidine-1-Carboxylate
105258-93-3
|
$1.00 | 1KG | 99.% | 50 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 1-Cbz-3-azetidinone
105258-93-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Benzyl 3-oxo-1-azetidinecarboxylate
105258-93-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- Benzyl 3-Oxoazetidine-1-Carboxylate
105258-93-3
- $1.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
