ChemicalBook >> CAS DataBase List >>1-benzhydrylazetidin-3-Ol
1-benzhydrylazetidin-3-Ol
- CAS No.
- 18621-17-5
- Chemical Name:
- 1-benzhydrylazetidin-3-Ol
- Synonyms
- 1-BENZHYDRYLAZETIDIN-3-OL;1-BENZHYDRYL-3-AZETIDINOL;NSC 319045;1-BenzhydryL;Baricitinib-008;BUTTPARK 37\04-13;1-Benzydrylazetan-3-ol;-benzhydrylazetidin-3-ol;N-Benzhydryl-3-azetidinol;N-BENZHYDRYLAZETIDIN-3-OL
- CBNumber:
- CB5495573
- Molecular Formula:
- C16H17NO
- Molecular Weight:
- 239.31
- MDL Number:
- MFCD00205109
- MOL File:
- 18621-17-5.mol
- MSDS File:
- SDS
Last updated:2025-07-24 18:13:44
| Melting point | 106 °C |
|---|---|
| Boiling point | 353.8±42.0 °C(Predicted) |
| Density | 1.189±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.24±0.20(Predicted) |
| color | Off-White to Pale Yellow |
| InChI | InChI=1S/C16H17NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-16,18H,11-12H2 |
| InChIKey | MMAJXKGUZYDTHV-UHFFFAOYSA-N |
| SMILES | N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(O)C1 |
| CAS DataBase Reference | 18621-17-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H314-H318 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| RIDADR | UN3259 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-benzhydrylazetidin-3-Ol price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D3907 | 1-(Diphenylmethyl)-3-hydroxyazetidine >98.0%(GC)(T) | 18621-17-5 | 5g | $59 | 2025-07-31 | Buy |
| TCI Chemical | D3907 | 1-(Diphenylmethyl)-3-hydroxyazetidine >98.0%(GC)(T) | 18621-17-5 | 25g | $202 | 2025-07-31 | Buy |
| TRC | B195500 | 1-Benzhydrylazetidin-3-ol | 18621-17-5 | 10g | $70 | 2021-12-16 | Buy |
| Usbiological | B1060-70 | 1-Benzhydrylazetidin-3-ol | 18621-17-5 | 2g | $425 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB18192 | 1-Benzhydrylazetidin-3-ol | 18621-17-5 | 2Kg | $450 | 2021-12-16 | Buy |
1-benzhydrylazetidin-3-Ol Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
1-(Diphenylmethyl)-3-hydroxyazetidine is used to identify inhibitors of CYP 3A4.
Synthesis
63477-43-0
18621-17-5
To a solution of 1-(diphenylmethylamino)-3-chloro-2-propanol (Intermediate 32, 276 g, 1 mol) in ethanol (2 L) was slowly added N,N-diisopropylethylamine (DIPEA, 129 g, 1 mol) at 0 °C. Subsequently, the reaction mixture was heated to 90 °C and refluxed overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford the crude product 1-diphenylmethyl-3-hydroxyazetidine (179 g, 75% yield). The product can be purified by recrystallization from a solvent mixture of acetone and petroleum ether.
References
[1] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 96
[2] Medicinal Chemistry Research, 2013, vol. 22, # 12, p. 5982 - 5989
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22
[4] Synthesis (Germany), 2018, vol. 50, # 5, p. 1020 - 1026
1-benzhydrylazetidin-3-Ol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
Global( 444)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21622 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| QINGDAO HONG JIN CHEMCIAL CO.,LTD. | 532-83657313 18663969289; | hjt@hong-jin.com | China | 227 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
View Lastest Price from 1-benzhydrylazetidin-3-Ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-17 | 1-(Diphenylmethyl)-3-hydroxyazetidine
18621-17-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-05-26 | 1- (Diphenylmethyl) -3-Hydroxyazetidine
18621-17-5
|
US $10.00 / kg | 1kg | 98% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-04-04 | 1-(Diphenylmethyl)-3-hydroxyazetidine
18621-17-5
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 1-(Diphenylmethyl)-3-hydroxyazetidine
18621-17-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- 1- (Diphenylmethyl) -3-Hydroxyazetidine
18621-17-5
- US $10.00 / kg
- 98%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 1-(Diphenylmethyl)-3-hydroxyazetidine
18621-17-5
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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1-(Diphenylmethyl)-3-hydroxyazetidine>
N-Diphenylmethyl-3-hydroxyazetidine
1-BenzhydryL
Baricitinib-008
1-Benzhydryl-3-Azetidinol 95%
C16H17NO 1-(Diphenylmethyl)-3-hydroxyazetidine 18621-17-5
-benzhydrylazetidin-3-ol
1-BENZHYLDRYL-3-HYDROXYAZETIDINE
N-Diphenylmethyl azetidine 3-ol
1-Diphenylmethyl-3-hydroxyazetidine - [D7433]
18621-17-5
Alcohols and Derivatives
Azelnidipine
Azetidines
Amines
Heterocycles
Ring Systems
Azetidine
N-Benzhydrylazetidin
18621-17-5
