3-Butyn-2-ol
- CAS No.
- 2028-63-9
- Chemical Name:
- 3-Butyn-2-ol
- Synonyms
- but-3-yn-2-ol;Butynol;1-Ethynylethanol;3-butyn-2-0l;3-Bytyn-2-ol;3-Butyn-2-ol;3-Butyne-2-Ol98%;3-Butyn-2-ol,97%;3-Butyn-2-ol >(R)-3-BUTYNE-2-OL
- CBNumber:
- CB8202679
- Molecular Formula:
- C4H6O
- Molecular Weight:
- 70.09
- MDL Number:
- MFCD00004541
- MOL File:
- 2028-63-9.mol
- MSDS File:
- SDS
| Melting point | -1.5°C |
|---|---|
| alpha | 0°(c=1, CHCl3) |
| Boiling point | 66-67 °C/150 mmHg (lit.) |
| Density | 0.894 g/mL at 25 °C (lit.) |
| vapor pressure | 11hPa at 20℃ |
| refractive index |
n |
| Flash point | 78 °F |
| storage temp. | Flammables area |
| Water Solubility | Completely miscible in water |
| pka | 13.28±0.20(Predicted) |
| form | Liquid |
| Specific Gravity | 0.894 |
| color | Clear colorless to light yellow |
| BRN | 635722 |
| InChI | 1S/C4H6O/c1-3-4(2)5/h1,4-5H,2H3 |
| InChIKey | GKPOMITUDGXOSB-UHFFFAOYSA-N |
| SMILES | CC(O)C#C |
| LogP | 1.1 at 35℃ |
| CAS DataBase Reference | 2028-63-9(CAS DataBase Reference) |
| NIST Chemistry Reference | 3-Butyn-2-ol(2028-63-9) |
| EPA Substance Registry System | 3-Butyn-2-ol (2028-63-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315-H319-H226 | |||||||||
| Precautionary statements | P501-P270-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P301+P310+P330-P403+P235-P405 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 10-25-36/38-36/37/38-24/25 | |||||||||
| Safety Statements | 26-45-36/37/39-16 | |||||||||
| RIDADR | UN 2929 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | ES0709800 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29052900 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 2 Dermal Acute Tox. 2 Inhalation Acute Tox. 2 Oral Aquatic Chronic 3 Eye Dam. 1 Flam. Liq. 2 Self-react. G Skin Irrit. 2 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
3-Butyn-2-ol price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 447986 | 3-Butyn-2-ol 97% | 2028-63-9 | 25ml | $233 | 2026-04-30 | Buy |
| Sigma-Aldrich | 447986 | 3-Butyn-2-ol 97% | 2028-63-9 | 100ml | $292 | 2026-04-30 | Buy |
| TCI Chemical | B0750 | 3-Butyn-2-ol (55% in Water, ca. 7.5mol/L) | 2028-63-9 | 25mL | $142 | 2021-12-16 | Buy |
| Usbiological | 424753 | 3-Butyn-2-ol | 2028-63-9 | 1g | $326 | 2026-06-03 | Buy |
| Usbiological | 424753 | 3-Butyn-2-ol | 2028-63-9 | 5g | $410 | 2026-06-03 | Buy |
3-Butyn-2-ol Chemical Properties,Uses,Production
Synthesis
The ketone (5.00 mmol) was dissolved in 50 mL of THF in a 50 mL round-bottom flask. The mixture was cooled to -78°C. At -78°C, magnesium acetylenyl chloride (5.5 mL, 5.5 mmol, 0.6 M toluene solution) was added dropwise to the mixture. The mixture was transferred to 0°C. The mixture was stirred for 1.5 hours. A saturated aqueous solution of NH4Cl (10 mL) was added to the mixture. The entire mixture was extracted with EtOAc (20 mL × 3). The combined organic layers were washed with brine (10 mL). The combined organic layers were dried with Na2SO4. The combined organic layers were filtered. The combined organic layers were concentrated under vacuum. The residue was purified by silica gel column chromatography using petroleum ether and ethyl acetate as eluents to give 3-butyn-2-ol.
Figure 3. Synthetic Route of Butyn-2-ol
Chemical Properties
clear colorless to light yellow liquid
Uses
3-Butyn-2-ol is an intermediate used to prepare aminoindanes with inhibitory activity toward acetylcholine esterase and monoamine oxidase useful as anti-Alzheimer's agents.
Flammability and Explosibility
Flammable
3-Butyn-2-ol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +86-13588737631 | inquiry@hengdian-group.com | China | 178 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from 3-Butyn-2-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 3-Butyn-2-ol
2028-63-9
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
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- 3-Butyn-2-ol
2028-63-9
- $9.80
- ≥99%
- Career Henan Chemical Co
