Ethisterone
- CAS No.
- 434-03-7
- Chemical Name:
- Ethisterone
- Synonyms
- Progestoral;17A-ETHYNYLTESTOSTERONE;Prone;Pranone;Pregnin;Gestoral;NSC-9565;Prodoxan;Produxan;Prolutol
- CBNumber:
- CB1207877
- Molecular Formula:
- C21H28O2
- Molecular Weight:
- 312.45
- MDL Number:
- MFCD00003656
- MOL File:
- 434-03-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 263-269 °C (lit.) |
|---|---|
| Boiling point | 392.36°C (rough estimate) |
| alpha | D23 +23.8° (dioxane); D25 -32.0° (pyridine) |
| Density | 1.0697 (rough estimate) |
| refractive index | 33 ° (C=1, Pyridine) |
| storage temp. | room temp |
| solubility | Soluble to 0.05 mg/mL (0.16 mM) in DMSO |
| form | Solid |
| pka | 13.10±0.60(Predicted) |
| color | Light yellow to yellow |
| biological source | synthetic (organic) |
| Water Solubility | soluble in chloroform, DMSO (0.05 mg/ml), acetone (slightly ), ethanol (<1 mg/ml at 25°C), and water (<1 mg/ml at 25°C). |
| Merck | 14,3741 |
| BRN | 1889895 |
| InChI | 1S/C21H28O2/c1-4-21(23)12-9-18-16-6-5-14-13-15(22)7-10-19(14,2)17(16)8-11-20(18,21)3/h1,13,16-18,23H,5-12H2,2-3H3/t16-,17+,18+,19+,20+,21+/m1/s1 |
| InChIKey | CHNXZKVNWQUJIB-CEGNMAFCSA-N |
| SMILES | C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CC[C@@]4(O)C#C |
| CAS DataBase Reference | 434-03-7 |
| FDA UNII | P201BVY1MJ |
| ATC code | G03DC04 |
| NIST Chemistry Reference | Ethisterone(434-03-7) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H410 |
| Precautionary statements | P201-P202-P273-P280-P308+P313-P391 |
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn,T |
| Risk Statements | 40-48-61 |
| Safety Statements | 22-24/25-45-53 |
| RIDADR | UN 2811 |
| WGK Germany | 3 |
| RTECS | TU5570250 |
| HS Code | 29372390 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Repr. 1A |
| REACH Registrations | Active |
Ethisterone price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E1001 | Ethisterone ≥99% (HPLC) | 434-03-7 | 25g | $277 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1261117 | Ethisterone United States Pharmacopeia (USP) Reference Standard | 434-03-7 | 50mg | $1140 | 2026-04-30 | Buy |
| Cayman Chemical | 22893 | Ethisterone ≥95% | 434-03-7 | 1g | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 22893 | Ethisterone ≥95% | 434-03-7 | 5g | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 22893 | Ethisterone ≥95% | 434-03-7 | 10g | $153 | 2026-04-30 | Buy |
Ethisterone Chemical Properties,Uses,Production
Description
Ethisterone is an orally bioavailable synthetic progestin and a derivative of testosterone (Item Nos. ISO60154 | 15645) that binds to progesterone and androgen receptors (EC50s = 23 and 23.1 nM, respectively, in yeast). Ethisterone (1 μM) downregulates progesterone receptors in MCF-7 cells.
Chemical Properties
Off-White Powder
Originator
Lutocyclin,Ciba
Uses
Ethisterone has been used as a component in Dulbecco′s modified eagle medium (DMEM) to culture the transfected COS-7 cell for transient transfection assay andgene transfection assay.
Uses
Synthetic progestogen; metabolite of Danazol; intermediate in the synthesis of Spironolactone
Definition
ChEBI: A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.
Manufacturing Process
0.5 part of δ5:6-17-ethinyl-androstendiol-(3:17) is dissolved in 10 parts of dry acetone, the solution is mixed with a solution of 1 part of tertiary aluminum butylate in 40 parts of absolute toluene and the whole is heated to boiling in a reflux apparatus for 21 hours. After the reaction mixture has cooled it is diluted with 100 parts of ether, the solution is washed with dilute mineral acid and with water, dried and the solvent is evaporated. In this manner there is obtained δ5:6-17-ethinyl-androstene-3-one-17-ol (ethisterone); MP: 270°- 272°C; it may be recrystallized from ethyl acetate.
Therapeutic Function
Progestin
General Description
Ethisterone is aprogestogen. It is a danazol derivative.
Biochem/physiol Actions
Ethisterone acts as a progestational agent. It is consumed by pregnant mothers to prevent miscarriage.
References
[1] L. MCROBB . Structure–activity relationships of synthetic progestins in a yeast-based in vitro androgen bioassay[J]. Journal of Steroid Biochemistry and Molecular Biology, 2008, 110 1: Pages 39-47. DOI: 10.1016/j.jsbmb.2007.10.008
[2] J.M. GLEDHILL . Progesterone receptor induction by danazol in cultured cancer cells and the rat uterus[J]. Journal of Steroid Biochemistry and Molecular Biology, 1992, 43 4: Pages 289-296. DOI: 10.1016/0960-0760(92)90163-d
Ethisterone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
View Lastest Price from Ethisterone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | Ethisterone
434-03-7
|
$35.00-52.00 | 99.50% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | Ethisterone
434-03-7
|
$35.00-52.00 | 99.50% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-15 | Ethisterone
434-03-7
|
$1.50 | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd |
-
- Ethisterone
434-03-7
- $35.00-52.00
- 99.50%
- TargetMol Chemicals Inc.
-
- Ethisterone
434-03-7
- $35.00-52.00
- 99.50%
- TargetMol Chemicals Inc.
-
- Ethisterone
434-03-7
- $1.50
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
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