Ethyl (R)-3-hydroxybutyrate
- CAS No.
- 24915-95-5
- Chemical Name:
- Ethyl (R)-3-hydroxybutyrate
- Synonyms
- ETHYL (R)-(-)-3-HYDROXYBUTYRATE;grape butyrate;(R)-grape butyrate;2-ethyl-3-hydroxybutanoate;ETHYL (R)-3-HYDROXYBUTYRATE;ETHYL (R)-3-HYDROXYBUTYLATE;ethyl (3R)-3-hydroxybutanoate;ETHYL R-(-)-3-HYDROXYBUTANOATE;(R)-(-)-Ethyl 3-Hydrobutyrate;Ethyl (R)-3-hydroxybutyrate,98%
- CBNumber:
- CB8214494
- Molecular Formula:
- C6H12O3
- Molecular Weight:
- 132.16
- MDL Number:
- MFCD00075386
- MOL File:
- 24915-95-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl (R)-(?)-3-hydroxybutyrate 98% | 347329 | 1g | $29.2 |
| Ethyl (R)-(?)-3-hydroxybutyrate 98% | 347329 | 5g | $94.1 |
| Ethyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC) | H1029 | 1g | $64 |
| Ethyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC) | H1029 | 5g | $132 |
| Ethyl (R)-(-)-3-Hydroxybutyrate ≥95% | 20659 | 1g | $38 |
| More product size | |||
| alpha | -45.5 º (589nm, c=1, CHCl3) |
|---|---|
| Boiling point | 75-76 °C/12 mmHg (lit.) |
| Density | 1.017 g/mL at 25 °C (lit.) |
| vapor pressure | 17.2Pa at 20℃ |
| refractive index |
n |
| Flash point | 148 °F |
| storage temp. | 2-8°C |
| pka | 14.45±0.20(Predicted) |
| form | Liquid |
| Specific Gravity | 1.017 |
| color | Clear, Colorless |
| optical activity | [α]20/D 46°, c = 1 in chloroform |
| Water Solubility | soluble |
| InChI | 1S/C6H12O3/c1-3-9-6(8)4-5(2)7/h5,7H,3-4H2,1-2H3/t5-/m1/s1 |
| InChIKey | OMSUIQOIVADKIM-RXMQYKEDSA-N |
| SMILES | CCOC(=O)C[C@@H](C)O |
| LogP | 0.341 at 20℃ |
| CAS DataBase Reference | 24915-95-5(CAS DataBase Reference) |
| UNSPSC Code | 12352108 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227 | |||||||||
| Precautionary statements | P210-P280-P403+P235-P501 | |||||||||
| Risk Statements | 36/37/38-52 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | CBL | |||||||||
| HS Code | 29181990 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Excepted Quantities | Non-Hazardous | |||||||||
| NFPA 704 |
|
Ethyl (R)-3-hydroxybutyrate price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 347329 | Ethyl (R)-(?)-3-hydroxybutyrate 98% | 24915-95-5 | 1g | $29.2 | 2026-03-19 | Buy |
| Sigma-Aldrich | 347329 | Ethyl (R)-(?)-3-hydroxybutyrate 98% | 24915-95-5 | 5g | $94.1 | 2026-03-19 | Buy |
| TCI Chemical | H1029 | Ethyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC) | 24915-95-5 | 1g | $64 | 2026-03-19 | Buy |
| TCI Chemical | H1029 | Ethyl (R)-(-)-3-Hydroxybutyrate >98.0%(GC) | 24915-95-5 | 5g | $132 | 2026-03-19 | Buy |
| Cayman Chemical | 20659 | Ethyl (R)-(-)-3-Hydroxybutyrate ≥95% | 24915-95-5 | 1g | $38 | 2024-03-01 | Buy |
Ethyl (R)-3-hydroxybutyrate Chemical Properties,Uses,Production
Description
Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.
Chemical Properties
clear colorless liquid
Uses
Ethyl (R)-(-)-3-hydroxybutyrate is a chiral building block for the preparation of bioactive compounds used in the pharmaceutical industry. It is formed during the hydrolysis of poly-3-hydroxybutyrate.
Definition
ChEBI: Ethyl (R)-3-hydroxybutanoate is an ethyl 3-hydroxybutyrate. It is functionally related to a (R)-3-hydroxybutyric acid.
General Description
Ethyl (R)-3-hydroxybutyrate is an enantiomer of 3-hydroxybutyric acid. It is synthesized from diethyl succinate in a one-pot, stereoselective, high-yield process by using asymmetric synthesis and hydrogenation. The reaction vessel used for this synthesis is a reaction solution that has been optimized to be resistant to high pressure and temperature. This product can be used as a renewable feedstock in the production of polyesters and other polymers.
Synthesis
(R)-β-Butryrolactone (20 g, 230 mmol) was dissolved in 500 mLethanol with 1.0 mL H2SO4 and stirred at room temperature. Aliquots(100 μL) were added to 1.0 mL of methanol and analyzed by GC-MS for conversion of the lactone. Upon completion (> 48 h), a small amount of solid sodium bicarbonate was added and the solvent removed by rotary evaporation. The residue was taken up in dichloromethane and washed with water. The water layer was extracted twice with ethyl acetate. The pooled organic layers were dried with magnesium sulfate, which was then filtered and the solvent removed by rotary evaporation to yield Ethyl (R)-3-hydroxybutyrate as a clear oil (20.2 g, 66%).
References
[1] AYELET FISHMAN. A two-step enzymatic resolution process for large-scale production of (S)- and (R)-ethyl-3-hydroxybutyrate[J]. Biotechnology and Bioengineering, 2001, 74 3: 256-263. DOI: 10.1002/bit.1115
Ethyl (R)-3-hydroxybutyrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChiRial Biomaterial Co Ltd | +86-19941513806 +86-19941513806 | cero.xia@chirial.com | China | 156 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3590 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5235 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Fluoropharm Co., Ltd. | +86-0571-85586753 +86-13336034509 | sales@fluoropharm.com | China | 1445 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29822 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
View Lastest Price from Ethyl (R)-3-hydroxybutyrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | Ethyl (R)-3-hydroxybutyrate
24915-95-5
|
US $1.10-9.90 / kg | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-04-16 | (R)-(-)-3-Hydroxy-n-butyric acid ethyl ester
24915-95-5
|
US $0.00 / kg | 200kg | 99% | 20000kg/month | GIHI CHEMICALS CO.,LIMITED | |
 |
2025-12-12 | Ethyl (R)-3-hydroxybutyrate
24915-95-5
|
US $1.00-4.00 / KG | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- Ethyl (R)-3-hydroxybutyrate
24915-95-5
- US $1.10-9.90 / kg
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- (R)-(-)-3-Hydroxy-n-butyric acid ethyl ester
24915-95-5
- US $0.00 / kg
- 99%
- GIHI CHEMICALS CO.,LIMITED
-
- Ethyl (R)-3-hydroxybutyrate
24915-95-5
- US $1.00-4.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
