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4-HYDROXY-3-METHOXYPHENYLACETONITRILE

4-HYDROXY-3-METHOXYPHENYLACETONITRILE structure

CAS No.: 4468-59-1

Chemical Name:: 4-HYDROXY-3-METHOXYPHENYLACETONITRILE

Synonyms: 2-(4-Hydroxy-3-methoxyphenyl)acetonitrile;HOMOVANILLONITRILE;4-Hydroxy-3-methoxybenzyl cyanide;4-HYDROXY-3-METHOXYPHENYLACETONITRILE;4-Hydroxy-3-methoxybenzeneacetonitrile;3-Methoxy-4-hydroxybenzeneacetonitrile;Benzeneacetonitrile, 4-hydroxy-3-methoxy-;2-(4-hydroxy-3-methoxy-phenyl)ethanenitrile;4-HYDROXY-3-METHOXYPHENYLACETONITRILE, 9 9%;Carbimazole Impurity 1 (Carbimazole EP Impurity A)

CBNumber:: CB8225898

Molecular Formula:: C9H9NO2

Molecular Weight:: 163.17

MDL Number:: MFCD00001920

MOL File:: 4468-59-1.mol

MSDS File:: SDS

Last updated:2026-06-04 16:00:12

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4-HYDROXY-3-METHOXYPHENYLACETONITRILE Properties

Melting point	56-57 °C (lit.)
Boiling point	135-145 °C/2 mmHg (lit.)
Density	1.2021 (rough estimate)
refractive index	1.5270 (estimate)
pka	9.69±0.18(Predicted)
form	powder
color	Off-white
InChI	1S/C9H9NO2/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,6,11H,4H2,1H3
InChIKey	SDVYWMWQCJEYTC-UHFFFAOYSA-N
SMILES	COc1cc(CC#N)ccc1O
CAS DataBase Reference	4468-59-1(CAS DataBase Reference)
FDA UNII	KBJ5T7NP94
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332-H315-H319-H335
Precautionary statements	P261-P280-P305+P351+P338
target organs	Respiratory system
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn,Xi
Risk Statements	20/21/22-36/37/38
Safety Statements	26-37/39
RIDADR	UN3439
WGK Germany	3
HazardClass	IRRITANT-HARMFUL
HS Code	2926907090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3
Limited Quantities	5.0 kg (11 lbs) (solid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

4-HYDROXY-3-METHOXYPHENYLACETONITRILE price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	223743	4-Hydroxy-3-methoxyphenylacetonitrile 99%	4468-59-1	1g	$77	2022-05-15	Buy
Biosynth	FH67972	(4-Hydroxy-3-methoxyphenyl)acetonitrile	4468-59-1	5g	$181.45	2026-06-04	Buy
Biosynth	FH67972	(4-Hydroxy-3-methoxyphenyl)acetonitrile	4468-59-1	10g	$272.1	2026-06-04	Buy
Biosynth	FH67972	(4-Hydroxy-3-methoxyphenyl)acetonitrile	4468-59-1	25g	$544.25	2026-06-04	Buy
Biosynth	FH67972	(4-Hydroxy-3-methoxyphenyl)acetonitrile	4468-59-1	50g	$907	2026-06-04	Buy

Product number	Packaging	Price	Buy
223743	1g	$77	Buy
FH67972	5g	$181.45	Buy
FH67972	10g	$272.1	Buy
FH67972	25g	$544.25	Buy
FH67972	50g	$907	Buy

4-HYDROXY-3-METHOXYPHENYLACETONITRILE Chemical Properties,Uses,Production

Uses

4-Hydroxy-3-methoxyphenylacetonitrile is a phenolic glycoside which is isolated from commercial Adenophora roots.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2502, 1976 DOI: 10.1021/jo00876a038

General Description

4-Hydroxy-3-methoxyphenylacetonitrile is a phenolic glycoside which is isolated from commercial Adenophora roots.

4-HYDROXY-3-METHOXYPHENYLACETONITRILE synthesis

Synthesis of 4-HYDROXY-3-METHOXYPHENYLACETONITRILE from sodium:cyanide and Vanillyl alcohol

4-HYDROXY-3-METHOXYPHENYLACETONITRILE Preparation Products And Raw materials

Raw materials

(3-Hydroxy-4-methoxy-phenyl)-acetonitrile 2-(Hydroxyimino)-3-(3-methoxy-4-hydroxyphenyl)propionic acid Phenol, 4-[(ethoxymethoxy)methyl]-2-methoxy- Vanillyl alcohol 2-Methoxy-4-[(methylamino)methyl]phenol

TETRABUTYLAMMONIUM CYANIDE POTASSIUM CYANIDE Sodium cyanide sodium:cyanide (3,4-Dimethoxyphenyl)acetonitrile

Vanillin

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Preparation Products

4-Benzyloxy-3-methoxyphenylacetonitrile

4-HYDROXY-3-METHOXYPHENYLACETONITRILE Suppliers

Global( 77)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Shanghai Hanhong Scientific Co.,Ltd.	64
Syntechem Co.,Ltd	57
Tianjin heowns Biochemical Technology Co., Ltd.	57
Clearsynth Labs Limited	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Bide Pharmatech Ltd.	60

4-HYDROXY-3-METHOXYPHENYLACETONITRILE Spectrum

4-HYDROXY-3-METHOXYPHENYLACETONITRILE(4468-59-1)MS 4-HYDROXY-3-METHOXYPHENYLACETONITRILE(4468-59-1)¹HNMR 4-HYDROXY-3-METHOXYPHENYLACETONITRILE(4468-59-1)¹³CNMR 4-HYDROXY-3-METHOXYPHENYLACETONITRILE(4468-59-1)IR1 4-HYDROXY-3-METHOXYPHENYLACETONITRILE(4468-59-1)IR2 4-HYDROXY-3-METHOXYPHENYLACETONITRILE(4468-59-1)Raman

4468-59-1(4-HYDROXY-3-METHOXYPHENYLACETONITRILE)Related Search:

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3-ETHOXY-4-METHOXYPHENYLACETONITRILE 2-HYDROXY-3-METHOXYPHENYLACETONITRILE 3,5-DIMETHOXY-4-HYDROXYPHENYL ACETONITRILE

1of4

Homovanillonitrile (4-hydroxy-3-methoxy-phenyl)acetonitrile 4-HYDROXY-3-METHOXYPHENYLACETONITRILE, 9 9% HOMOVANILLONITRILE 4-HYDROXY-3-METHOXYPHENYLACETONITRILE 2-(4-hydroxy-3-methoxy-phenyl)ethanenitrile (4-hydroxy-3-methoxyphenyl)acetonitrile(SALTDATA: FREE) 3-Methoxy-4-hydroxybenzeneacetonitrile 4-Hydroxy-3-methoxybenzeneacetonitrile 4-Hydroxy-3-methoxybenzyl cyanide (2S)-7-hydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one Benzeneacetonitrile, 4-hydroxy-3-methoxy- 4-Hydroxy-3-methoxyphenylacetonitrile Carbimazole Impurity 1 (Carbimazole EP Impurity A) 2-(4-Hydroxy-3-methoxyphenyl)acetonitrile 4468-59-1 HOC6H3OCH3CH2CN Building Blocks C8 to C9 Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks Aromatic Nitriles Building Blocks C8 to C9 Chemical Synthesis Cyanides/Nitriles Nitrogen Compounds Organic Building Blocks