Patomostat mesilate
- CAS No.
- 114568-32-0
- Chemical Name:
- Patomostat mesilate
- Synonyms
- E-3123;E-3123 mesylate;Patamostat mesylate;Patomostat mesilate
- CBNumber:
- CB82382283
- Molecular Formula:
- C21H24N4O7S2
- Molecular Weight:
- 508.56786
- MDL Number:
- MOL File:
- 114568-32-0.mol
- MSDS File:
- SDS
| FDA UNII | 4697U796PV |
|---|
Patomostat mesilate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA009UK2 | Patomostat mesilate | 114568-32-0 | 1mg | $211 | 2026-05-28 | Buy |
| aablocks | AA009UK2 | Patomostat mesilate | 114568-32-0 | 5mg | $486 | 2026-05-28 | Buy |
| aablocks | AA009UK2 | Patomostat mesilate | 114568-32-0 | 10mg | $639 | 2026-05-28 | Buy |
| aablocks | AA009UK2 | Patomostat mesilate | 114568-32-0 | 25mg | $956 | 2026-05-28 | Buy |
| ACHEMBLOCK | AD264989 | Patamostat mesylate 98% | 114568-32-0 | 1MG | $245 | 2026-05-27 | Buy |
Patomostat mesilate Chemical Properties, Uses, Production
Uses
Patamostat (E-3123) mesylate is a potent protease inhibitor. Patamostat mesylate potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat mesylate may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].
in vivo
Patamostat mesylate (intravenous infusion) at 0.03-0.3 mg/kg in rats or at 0.3-3.0 mg/kg in rabbits reduces mortality after the induction of pancreatitis in a dose-dependent manner[1].
Patamostat mesylate (1.0-3.0 mg/kg; intravenous infusion) reduces the increases of serum trypsin and lipase activities in dogs with pancreatitis[1].
Patamostat mesylate (2 mg/kg per h; continuous infusion) improves almost all parameters, including mortality rate, serum and ascitic fluid amylase levels, plasma endotoxin and serum FDP levels, and distribution of lysosomal enzyme in male Wistar rats[2].
| Animal Model: | Male Wistar rats weighing about 350 g[2] |
| Dosage: | 2 mg/kg |
| Administration: | Continuous infusion per h for 1 h |
| Result: | Significantly improved the survival rate. |
References
[1] K Miyamoto, et al. [Effects of E-3123, a New Protease Inhibitor, on Several Protease Activities and on Experimental Acute Pancreatitis]. Nihon Yakurigaku Zasshi. 1988 May;91(5):285-93. DOI:10.1254/fpj.91.285
[2] T Hirano, et al. Protective Effect of a Cephalosporin, Shiomarin, Plus a New Potent Protease Inhibitor, E3123, on Rat Taurocholate-Induced Pancreatitis. J Gastroenterol Hepatol. Jan-Feb 1993;8(1):52-9. DOI:10.1111/j.1440-1746.1993.tb01175.x
Patomostat mesilate Preparation Products And Raw materials
Raw materials
Preparation Products
Patomostat mesilate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 58 |
View Latest Price from Patomostat mesilate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Patamostat mesylate
114568-32-0
|
$238.00-773.00 | 99.82% | 10g | TargetMol Chemicals Inc. |
-
- Patamostat mesylate
114568-32-0
- $238.00-773.00
- 99.82%
- TargetMol Chemicals Inc.
